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Effects of the cross-linkers on the buckling of microtubules in cells

Si Li, Chengyuan Wang Orcid Logo, Perumal Nithiarasu Orcid Logo

Journal of Biomechanics, Volume: 72, Pages: 167 - 172

Swansea University Authors: Chengyuan Wang Orcid Logo, Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1016/j.jbiomech.2018.03.002

Abstract

In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the...

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Published in: Journal of Biomechanics
ISSN: 00219290
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa38961
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first_indexed 2018-03-07T14:09:48Z
last_indexed 2018-05-08T19:33:11Z
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spelling 2018-05-08T15:21:42.5676406 v2 38961 2018-03-07 Effects of the cross-linkers on the buckling of microtubules in cells fdea93ab99f51d0b3921d3601876c1e5 0000-0002-1001-2537 Chengyuan Wang Chengyuan Wang true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2018-03-07 MECH In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the two-dimensional-linkers were replaced by the three-dimensional (3D) ones. Then, the effects of the radial orientation and the axial density of the 3D-linkers were examined, showing that more uniform distribution of the radial orientation leads to the higher critical load with 3D buckling modes, while the inhomogeneity of the axial density results in the localized buckling patterns. The results demonstrated the important role of the cross-linker in regulating MT stiffness, revealed the physics of the experimentally observed localized buckling and these results will pave the way to a new multi-component mechanics model for whole cells. Journal Article Journal of Biomechanics 72 167 172 00219290 Microtubules; 3D localized buckling; Protein cross-linkers; Local density of linkers 31 12 2018 2018-12-31 10.1016/j.jbiomech.2018.03.002 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2018-05-08T15:21:42.5676406 2018-03-07T09:00:42.2233574 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Si Li 1 Chengyuan Wang 0000-0002-1001-2537 2 Perumal Nithiarasu 0000-0002-4901-2980 3 0038961-15032018092939.pdf li2018(3).pdf 2018-03-15T09:29:39.7070000 Output 1759879 application/pdf Accepted Manuscript true 2019-03-12T00:00:00.0000000 true eng
title Effects of the cross-linkers on the buckling of microtubules in cells
spellingShingle Effects of the cross-linkers on the buckling of microtubules in cells
Chengyuan Wang
Perumal Nithiarasu
title_short Effects of the cross-linkers on the buckling of microtubules in cells
title_full Effects of the cross-linkers on the buckling of microtubules in cells
title_fullStr Effects of the cross-linkers on the buckling of microtubules in cells
title_full_unstemmed Effects of the cross-linkers on the buckling of microtubules in cells
title_sort Effects of the cross-linkers on the buckling of microtubules in cells
author_id_str_mv fdea93ab99f51d0b3921d3601876c1e5
3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv fdea93ab99f51d0b3921d3601876c1e5_***_Chengyuan Wang
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Chengyuan Wang
Perumal Nithiarasu
author2 Si Li
Chengyuan Wang
Perumal Nithiarasu
format Journal article
container_title Journal of Biomechanics
container_volume 72
container_start_page 167
publishDate 2018
institution Swansea University
issn 00219290
doi_str_mv 10.1016/j.jbiomech.2018.03.002
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
document_store_str 1
active_str 0
description In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the two-dimensional-linkers were replaced by the three-dimensional (3D) ones. Then, the effects of the radial orientation and the axial density of the 3D-linkers were examined, showing that more uniform distribution of the radial orientation leads to the higher critical load with 3D buckling modes, while the inhomogeneity of the axial density results in the localized buckling patterns. The results demonstrated the important role of the cross-linker in regulating MT stiffness, revealed the physics of the experimentally observed localized buckling and these results will pave the way to a new multi-component mechanics model for whole cells.
published_date 2018-12-31T03:49:27Z
_version_ 1763752402823938048
score 11.037056

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