Journal article 893 views 246 downloads
Effects of the cross-linkers on the buckling of microtubules in cells
Si Li,
Chengyuan Wang 
,
Perumal Nithiarasu
,
Perumal Nithiarasu
Journal of Biomechanics, Volume: 72, Pages: 167 - 172
Swansea University Authors:
Chengyuan Wang , Perumal Nithiarasu
-
PDF | Accepted Manuscript
Download (1.7MB)
DOI (Published version): 10.1016/j.jbiomech.2018.03.002
Abstract
In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the...
| Published in: | Journal of Biomechanics |
|---|---|
| ISSN: | 00219290 |
| Published: |
2018
|
| Online Access: |
Check full text
|
| URI: | https://cronfa.swan.ac.uk/Record/cronfa38961 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract: |
In cells, the protein cross-linkers lead to a distinct buckling behavior of microtubules (MTs) different from the buckling of individual MTs. This paper thus aims to examine this issue via the molecular structural mechanics (MSM) simulations. The transition of buckling responses was captured as the two-dimensional-linkers were replaced by the three-dimensional (3D) ones. Then, the effects of the radial orientation and the axial density of the 3D-linkers were examined, showing that more uniform distribution of the radial orientation leads to the higher critical load with 3D buckling modes, while the inhomogeneity of the axial density results in the localized buckling patterns. The results demonstrated the important role of the cross-linker in regulating MT stiffness, revealed the physics of the experimentally observed localized buckling and these results will pave the way to a new multi-component mechanics model for whole cells. |
|---|---|
| Keywords: |
Microtubules; 3D localized buckling; Protein cross-linkers; Local density of linkers |
| College: |
Faculty of Science and Engineering |
| Start Page: |
167 |
| End Page: |
172 |