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Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study

Grith Møller, Jens Rikardt Andersen, Christian Ritz, Marta P. Silvestre, Santiago Navas-Carretero, Elli Jalo, Pia Christensen, Elizabeth Simpson, Moira Taylor, J. Martinez, Ian Macdonald, Nils Swindell, Kelly Mackintosh Orcid Logo, Gareth Stratton Orcid Logo, Mikael Fogelholm, Thomas Larsen, Sally Poppitt, Lars Dragsted, Anne Raben

Nutrients, Volume: 10, Issue: 1

Swansea University Authors: Kelly Mackintosh Orcid Logo, Gareth Stratton Orcid Logo

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DOI (Published version): 10.3390/nu10010054

Abstract

Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-dia...

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Published in: Nutrients
ISSN: 2072-6643 2072-6643
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa37940
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The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. 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spelling 2021-01-14T13:50:30.4131921 v2 37940 2018-01-05 Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 6d62b2ed126961bed81a94a2beba8a01 0000-0001-5618-0803 Gareth Stratton Gareth Stratton true false 2018-01-05 STSC Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were no associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults. Journal Article Nutrients 10 1 2072-6643 2072-6643 pre-diabetes; dietary protein; creatinine clearance; glomerular filtration rate; albumin; urea 9 1 2018 2018-01-09 10.3390/nu10010054 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2021-01-14T13:50:30.4131921 2018-01-05T09:47:24.2813936 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Grith Møller 1 Jens Rikardt Andersen 2 Christian Ritz 3 Marta P. Silvestre 4 Santiago Navas-Carretero 5 Elli Jalo 6 Pia Christensen 7 Elizabeth Simpson 8 Moira Taylor 9 J. Martinez 10 Ian Macdonald 11 Nils Swindell 12 Kelly Mackintosh 0000-0003-0355-6357 13 Gareth Stratton 0000-0001-5618-0803 14 Mikael Fogelholm 15 Thomas Larsen 16 Sally Poppitt 17 Lars Dragsted 18 Anne Raben 19 0037940-09012018091243.pdf moller2018.pdf 2018-01-09T09:12:43.4870000 Output 300601 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution License (CC-BY). true eng http://creativecommons.org/licenses/by/4.0/
title Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study
spellingShingle Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study
Kelly Mackintosh
Gareth Stratton
title_short Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study
title_full Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study
title_fullStr Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study
title_full_unstemmed Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study
title_sort Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention—A Preview Sub-Study
author_id_str_mv bdb20e3f31bcccf95c7bc116070c4214
6d62b2ed126961bed81a94a2beba8a01
author_id_fullname_str_mv bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
6d62b2ed126961bed81a94a2beba8a01_***_Gareth Stratton
author Kelly Mackintosh
Gareth Stratton
author2 Grith Møller
Jens Rikardt Andersen
Christian Ritz
Marta P. Silvestre
Santiago Navas-Carretero
Elli Jalo
Pia Christensen
Elizabeth Simpson
Moira Taylor
J. Martinez
Ian Macdonald
Nils Swindell
Kelly Mackintosh
Gareth Stratton
Mikael Fogelholm
Thomas Larsen
Sally Poppitt
Lars Dragsted
Anne Raben
format Journal article
container_title Nutrients
container_volume 10
container_issue 1
publishDate 2018
institution Swansea University
issn 2072-6643
2072-6643
doi_str_mv 10.3390/nu10010054
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
active_str 0
description Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were no associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.
published_date 2018-01-09T03:47:54Z
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