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On the behaviour of lung tissue under tension and compression

Pinelopi Andrikakou, Karthik Vickraman, Hari Arora Orcid Logo

Scientific Reports, Volume: 6, Issue: 1

Swansea University Author: Hari Arora Orcid Logo

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DOI (Published version): 10.1038/srep36642

Abstract

Lung injuries are common among those who suffer an impact or trauma. The relative severity of injuries up to physical tearing of tissue have been documented in clinical studies. However, the specific details of energy required to cause visible damage to the lung parenchyma are lacking. Furthermore,...

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Published in: Scientific Reports
ISSN: 2045-2322
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa37124
first_indexed 2017-11-28T20:12:56Z
last_indexed 2018-02-09T05:30:12Z
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spelling 2017-11-28T13:39:36.8958864 v2 37124 2017-11-28 On the behaviour of lung tissue under tension and compression ed7371c768e9746008a6807f9f7a1555 0000-0002-9790-0907 Hari Arora Hari Arora true false 2017-11-28 EAAS Lung injuries are common among those who suffer an impact or trauma. The relative severity of injuries up to physical tearing of tissue have been documented in clinical studies. However, the specific details of energy required to cause visible damage to the lung parenchyma are lacking. Furthermore, the limitations of lung tissue under simple mechanical loading are also not well documented. This study aimed to collect mechanical test data from freshly excised lung, obtained from both Sprague-Dawley rats and New Zealand White rabbits. Compression and tension tests were conducted at three different strain rates: 0.25, 2.5 and 25 min−1. This study aimed to characterise the quasi-static behaviour of the bulk tissue prior to extending to higher rates. A nonlinear viscoelastic analytical model was applied to the data to describe their behaviour. Results exhibited asymmetry in terms of differences between tension and compression. The rabbit tissue also appeared to exhibit stronger viscous behaviour than the rat tissue. As a narrow strain rate band is explored here, no conclusions are being drawn currently regarding the rate sensitivity of rat tissue. However, this study does highlight both the clear differences between the two tissue types and the important role that composition and microstructure can play in mechanical response. Journal Article Scientific Reports 6 1 2045-2322 biomedical engineering, tissues 30 11 2016 2016-11-30 10.1038/srep36642 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2017-11-28T13:39:36.8958864 2017-11-28T13:37:11.5453729 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Pinelopi Andrikakou 1 Karthik Vickraman 2 Hari Arora 0000-0002-9790-0907 3 0037124-28112017133930.pdf andrikakou2016.pdf 2017-11-28T13:39:30.1730000 Output 2009410 application/pdf Version of Record true 2017-11-28T00:00:00.0000000 false eng
title On the behaviour of lung tissue under tension and compression
spellingShingle On the behaviour of lung tissue under tension and compression
Hari Arora
title_short On the behaviour of lung tissue under tension and compression
title_full On the behaviour of lung tissue under tension and compression
title_fullStr On the behaviour of lung tissue under tension and compression
title_full_unstemmed On the behaviour of lung tissue under tension and compression
title_sort On the behaviour of lung tissue under tension and compression
author_id_str_mv ed7371c768e9746008a6807f9f7a1555
author_id_fullname_str_mv ed7371c768e9746008a6807f9f7a1555_***_Hari Arora
author Hari Arora
author2 Pinelopi Andrikakou
Karthik Vickraman
Hari Arora
format Journal article
container_title Scientific Reports
container_volume 6
container_issue 1
publishDate 2016
institution Swansea University
issn 2045-2322
doi_str_mv 10.1038/srep36642
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description Lung injuries are common among those who suffer an impact or trauma. The relative severity of injuries up to physical tearing of tissue have been documented in clinical studies. However, the specific details of energy required to cause visible damage to the lung parenchyma are lacking. Furthermore, the limitations of lung tissue under simple mechanical loading are also not well documented. This study aimed to collect mechanical test data from freshly excised lung, obtained from both Sprague-Dawley rats and New Zealand White rabbits. Compression and tension tests were conducted at three different strain rates: 0.25, 2.5 and 25 min−1. This study aimed to characterise the quasi-static behaviour of the bulk tissue prior to extending to higher rates. A nonlinear viscoelastic analytical model was applied to the data to describe their behaviour. Results exhibited asymmetry in terms of differences between tension and compression. The rabbit tissue also appeared to exhibit stronger viscous behaviour than the rat tissue. As a narrow strain rate band is explored here, no conclusions are being drawn currently regarding the rate sensitivity of rat tissue. However, this study does highlight both the clear differences between the two tissue types and the important role that composition and microstructure can play in mechanical response.
published_date 2016-11-30T13:20:46Z
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score 11.048042

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