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The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering

Chris J. Mortimer, Chris J. Wright, Christopher Wright Orcid Logo

Biotechnology Journal, Volume: 12, Start page: 1600693

Swansea University Author: Christopher Wright Orcid Logo

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DOI (Published version): 10.1002/biot.201600693

Abstract

This paper reviews the use of iron oxide nanoparticle-nanofiber composites in tissue engineering with a focus on the electrospinning technique. Electrospinning is an established method of scaffold fabrication offering a number of key advantages which include its facile nature, with electrospun mater...

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Published in: Biotechnology Journal
ISSN: 1860-6768
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa32988
first_indexed 2017-04-11T19:00:48Z
last_indexed 2018-02-09T05:21:31Z
id cronfa32988
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spelling 2017-07-31T14:03:07.0516492 v2 32988 2017-04-11 The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering 235e125ac3463e2ee7fc98604bf879ce 0000-0003-2375-8159 Christopher Wright Christopher Wright true false 2017-04-11 EAAS This paper reviews the use of iron oxide nanoparticle-nanofiber composites in tissue engineering with a focus on the electrospinning technique. Electrospinning is an established method of scaffold fabrication offering a number of key advantages which include its facile nature, with electrospun materials offering a high surface area to volume ratio, potential for the release of drugs and antimicrobials, controllable fiber diameters and high porosity and permeability. A number of different techniques for the preparation of iron oxide nanoparticles including their functionalization are discussed along with their applications in the biomedical field. The review then focusses on the fabrication of nanoparticle-nanofiber composite scaffolds formed using electrospinning. The advantages and disadvantages of current fabrication techniques are discussed including the fabrication of nanofibers using pre-synthesized nanoparticles and post-treatment synthesized nanoparticles. We demonstrate that emerging in-situ synthesis techniques show promise by offering a reduced number of steps and simpler procedures for the production of magnetic scaffolds. These scaffolds have a number of applications in tissue engineering, allowing for improved bone and tissue repair. Journal Article Biotechnology Journal 12 1600693 1860-6768 Electrospinning; Iron oxide nanoparticles; In-situ synthesis; Nanoparticle-Nanofiber composites; Tissue engineering scaffolds 4 7 2017 2017-07-04 10.1002/biot.201600693 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2017-07-31T14:03:07.0516492 2017-04-11T17:19:45.7047506 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Chris J. Mortimer 1 Chris J. Wright 2 Christopher Wright 0000-0003-2375-8159 3 0032988-04052017110903.pdf mortimer2017.pdf 2017-05-04T11:09:03.2470000 Output 1191908 application/pdf Accepted Manuscript true 2018-06-21T00:00:00.0000000 true eng
title The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering
spellingShingle The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering
Christopher Wright
title_short The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering
title_full The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering
title_fullStr The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering
title_full_unstemmed The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering
title_sort The fabrication of iron oxide nanoparticle-nanofiber composites by electrospinning and their applications in tissue engineering
author_id_str_mv 235e125ac3463e2ee7fc98604bf879ce
author_id_fullname_str_mv 235e125ac3463e2ee7fc98604bf879ce_***_Christopher Wright
author Christopher Wright
author2 Chris J. Mortimer
Chris J. Wright
Christopher Wright
format Journal article
container_title Biotechnology Journal
container_volume 12
container_start_page 1600693
publishDate 2017
institution Swansea University
issn 1860-6768
doi_str_mv 10.1002/biot.201600693
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description This paper reviews the use of iron oxide nanoparticle-nanofiber composites in tissue engineering with a focus on the electrospinning technique. Electrospinning is an established method of scaffold fabrication offering a number of key advantages which include its facile nature, with electrospun materials offering a high surface area to volume ratio, potential for the release of drugs and antimicrobials, controllable fiber diameters and high porosity and permeability. A number of different techniques for the preparation of iron oxide nanoparticles including their functionalization are discussed along with their applications in the biomedical field. The review then focusses on the fabrication of nanoparticle-nanofiber composite scaffolds formed using electrospinning. The advantages and disadvantages of current fabrication techniques are discussed including the fabrication of nanofibers using pre-synthesized nanoparticles and post-treatment synthesized nanoparticles. We demonstrate that emerging in-situ synthesis techniques show promise by offering a reduced number of steps and simpler procedures for the production of magnetic scaffolds. These scaffolds have a number of applications in tissue engineering, allowing for improved bone and tissue repair.
published_date 2017-07-04T01:17:52Z
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score 11.04748

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