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Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature

Chitra Murali, Perumal Nithiarasu Orcid Logo

Journal of Modeling in Mechanics and Materials, Volume: 1, Issue: 1

Swansea University Author: Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1515/jmmm-2016-0157

Abstract

A robust computational model is proposed to investigate the non-Newtonian nature of blood flow due to rouleaux formation in microvasculature. The model consists of appropriate forces responsible for red blood cell (RBC) aggregation in the microvasculature, tracking of RBCs, and coupling between plas...

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Published in: Journal of Modeling in Mechanics and Materials
ISSN: 2328-2355
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa31551
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last_indexed 2018-02-09T05:18:36Z
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spelling 2017-02-20T10:20:49.5315385 v2 31551 2017-01-04 Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2017-01-04 ACEM A robust computational model is proposed to investigate the non-Newtonian nature of blood flow due to rouleaux formation in microvasculature. The model consists of appropriate forces responsible for red blood cell (RBC) aggregation in the microvasculature, tracking of RBCs, and coupling between plasma flow and RBCs. The RBC aggregation results have been compared against the available data. The importance of different hydrodynamic forces on red blood cell aggregation has been delineated by comparing the time dependent path of the RBCs. The rheological changes to the blood flow have been investigated under different shear rates and hematocrit values and quantified with and without RBC aggregation. The results obtained in terms of wall shear stress (WSS) and blood viscosity indicate a significant difference between Newtonian and powerlaw fluid assumptions. Journal Article Journal of Modeling in Mechanics and Materials 1 1 2328-2355 red blood cell; rouleaux; microcirculation; wall shear stress; blood flow; non-newtonian 31 1 2017 2017-01-31 10.1515/jmmm-2016-0157 COLLEGE NANME Aerospace, Civil, Electrical, and Mechanical Engineering COLLEGE CODE ACEM Swansea University 2017-02-20T10:20:49.5315385 2017-01-04T08:46:56.7042839 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Chitra Murali 1 Perumal Nithiarasu 0000-0002-4901-2980 2 0031551-04012017084929.pdf murali2016.pdf 2017-01-04T08:49:29.7570000 Output 1452172 application/pdf Accepted Manuscript true 2018-01-31T00:00:00.0000000 false
title Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature
spellingShingle Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature
Perumal Nithiarasu
title_short Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature
title_full Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature
title_fullStr Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature
title_full_unstemmed Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature
title_sort Red blood cell (RBC) aggregation and its influence on non-Newtonian nature of blood in microvasculature
author_id_str_mv 3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv 3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Perumal Nithiarasu
author2 Chitra Murali
Perumal Nithiarasu
format Journal article
container_title Journal of Modeling in Mechanics and Materials
container_volume 1
container_issue 1
publishDate 2017
institution Swansea University
issn 2328-2355
doi_str_mv 10.1515/jmmm-2016-0157
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
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description A robust computational model is proposed to investigate the non-Newtonian nature of blood flow due to rouleaux formation in microvasculature. The model consists of appropriate forces responsible for red blood cell (RBC) aggregation in the microvasculature, tracking of RBCs, and coupling between plasma flow and RBCs. The RBC aggregation results have been compared against the available data. The importance of different hydrodynamic forces on red blood cell aggregation has been delineated by comparing the time dependent path of the RBCs. The rheological changes to the blood flow have been investigated under different shear rates and hematocrit values and quantified with and without RBC aggregation. The results obtained in terms of wall shear stress (WSS) and blood viscosity indicate a significant difference between Newtonian and powerlaw fluid assumptions.
published_date 2017-01-31T07:04:11Z
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score 11.048171

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