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Role of the inter-protofilament sliding in the bending of protein microtubules

Chengyuan Wang, Zhigang Guo, Ruijie Wang, Ying Luo

Journal of Biomechanics, Volume: 49, Issue: 16, Pages: 3803 - 3807

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DOI (Published version): 10.1016/j.jbiomech.2016.10.008

Abstract

This paper aims to identify the role of the inter-protofilament (PF) sliding in the bending of microtubules (MTs). A molecular structural model (MSM) was employed to study the dependence of bending on the inter-PF bonds. It was found that the inter-PF bonds serve as an angle spring that controls the...

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Published in: Journal of Biomechanics
ISSN: 0021-9290
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa30719
first_indexed 2016-10-19T19:24:35Z
last_indexed 2017-02-27T04:50:10Z
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recordtype SURis
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spelling v2 30719 2016-10-19 Role of the inter-protofilament sliding in the bending of protein microtubules Chengyuan Wang Chengyuan Wang true false fdea93ab99f51d0b3921d3601876c1e5 e83b6eedde9a46400be929fad445965c JbaOYyfOKaYk6lMrgYgnuMXSD9apmhwp34LCq09fig8= 2016-10-19 EEN This paper aims to identify the role of the inter-protofilament (PF) sliding in the bending of microtubules (MTs). A molecular structural model (MSM) was employed to study the dependence of bending on the inter-PF bonds. It was found that the inter-PF bonds serve as an angle spring that controls the inter-PF sliding during the bending. When the angle spring is soft inter-PF sliding occurs leading to the length-dependent bending stiffness of MTs. Such a size dependent bending stiffness may also affect the vibration and buckling behavior of MTs where bending deformation is predominant. Journal article Journal of Biomechanics 49 16 3803 3807 0021-9290 8 12 2016 2016-12-08 10.1016/j.jbiomech.2016.10.008 College of Engineering College of Engineering None Doctoral None College of Engineering Engineering Chengyuan Wang 1 Zhigang Guo 2 Ruijie Wang 3 Ying Luo 4 Under embargo Under embargo 2016-10-19T14:25:57.873 Output 980988 application/pdf AM true Published to Cronfa 19/10/2016 2017-10-18T00:00:00 false
title Role of the inter-protofilament sliding in the bending of protein microtubules
spellingShingle Role of the inter-protofilament sliding in the bending of protein microtubules
Wang, Chengyuan
title_short Role of the inter-protofilament sliding in the bending of protein microtubules
title_full Role of the inter-protofilament sliding in the bending of protein microtubules
title_fullStr Role of the inter-protofilament sliding in the bending of protein microtubules
title_full_unstemmed Role of the inter-protofilament sliding in the bending of protein microtubules
title_sort Role of the inter-protofilament sliding in the bending of protein microtubules
author_id_str_mv fdea93ab99f51d0b3921d3601876c1e5
author_id_fullname_str_mv fdea93ab99f51d0b3921d3601876c1e5_***_Wang, Chengyuan
author Wang, Chengyuan
author2 Chengyuan Wang
Zhigang Guo
Ruijie Wang
Ying Luo
format Journal article
container_title Journal of Biomechanics
container_volume 49
container_issue 16
container_start_page 3803
publishDate 2016
institution Cronfa
issn 0021-9290
doi_str_mv 10.1016/j.jbiomech.2016.10.008
college_str College of Engineering
hierarchytype
hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
document_store_str 0
active_str 1
description This paper aims to identify the role of the inter-protofilament (PF) sliding in the bending of microtubules (MTs). A molecular structural model (MSM) was employed to study the dependence of bending on the inter-PF bonds. It was found that the inter-PF bonds serve as an angle spring that controls the inter-PF sliding during the bending. When the angle spring is soft inter-PF sliding occurs leading to the length-dependent bending stiffness of MTs. Such a size dependent bending stiffness may also affect the vibration and buckling behavior of MTs where bending deformation is predominant.
published_date 2016-12-08T04:50:10Z
_version_ 1560460405978955776
score 11.047609

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