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A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew Lawrence, Ahmed Sabra, Gavin Mills, Suresh G. Pillai, Wendy Abdullah, Karl Hawkins Orcid Logo, Roger H. K. Morris, Simon J. Davidson, Lindsay D´Silva, Daniel Curtis Orcid Logo, Rowan Brown Orcid Logo, John W. Weisel, Rhodri Williams Orcid Logo, Adrian Evans Orcid Logo

British Journal of Haematology, Volume: 168, Issue: 4, Pages: 571 - 575

Swansea University Authors: Matthew Lawrence, Ahmed Sabra, Karl Hawkins Orcid Logo, Lindsay D´Silva, Daniel Curtis Orcid Logo, Rowan Brown Orcid Logo, Rhodri Williams Orcid Logo, Adrian Evans Orcid Logo

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DOI (Published version): 10.1111/bjh.13173

Abstract

This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘a...

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Published in: British Journal of Haematology
ISSN: 0007-1048
Published: Wiley 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa27555
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spelling 2022-11-02T16:34:52.8816728 v2 27555 2016-04-29 A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism 262d0cae7663ded863d6e2de15757f3c Matthew Lawrence Matthew Lawrence true false 97b3ad56338338453cbee42046817655 Ahmed Sabra Ahmed Sabra true false 77c39404a9a98c6e2283d84815cba053 0000-0003-0174-4151 Karl Hawkins Karl Hawkins true false 01ccf114efd431d0cab9b3ef591d7f02 Lindsay D´Silva Lindsay D´Silva true false e76ff28a23af2fe37099c4e9a24c1e58 0000-0002-6955-0524 Daniel Curtis Daniel Curtis true false d7db8d42c476dfa69c15ce06d29bd863 0000-0003-3628-2524 Rowan Brown Rowan Brown true false 642bf793695f412ed932f1ea4d9bc3f1 0000-0002-6912-5288 Rhodri Williams Rhodri Williams true false 21761f6eb805546a561c9f036e85405b 0000-0002-0814-5162 Adrian Evans Adrian Evans true false 2016-04-29 BMS This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence. Journal Article British Journal of Haematology 168 4 571 575 Wiley 0007-1048 1 2 2015 2015-02-01 10.1111/bjh.13173 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2022-11-02T16:34:52.8816728 2016-04-29T11:29:28.3226576 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Matthew Lawrence 1 Ahmed Sabra 2 Gavin Mills 3 Suresh G. Pillai 4 Wendy Abdullah 5 Karl Hawkins 0000-0003-0174-4151 6 Roger H. K. Morris 7 Simon J. Davidson 8 Lindsay D´Silva 9 Daniel Curtis 0000-0002-6955-0524 10 Rowan Brown 0000-0003-3628-2524 11 John W. Weisel 12 Rhodri Williams 0000-0002-6912-5288 13 Adrian Evans 0000-0002-0814-5162 14 27555__8327__61e0b5bf553741baa94b468f39d8127b.pdf 27555.pdf 2018-03-19T11:46:20.0030000 Output 543402 application/pdf Accepted Manuscript true 2017-04-25T00:00:00.0000000 true eng
title A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
spellingShingle A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
Matthew Lawrence
Ahmed Sabra
Karl Hawkins
Lindsay D´Silva
Daniel Curtis
Rowan Brown
Rhodri Williams
Adrian Evans
title_short A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
title_full A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
title_fullStr A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
title_full_unstemmed A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
title_sort A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
author_id_str_mv 262d0cae7663ded863d6e2de15757f3c
97b3ad56338338453cbee42046817655
77c39404a9a98c6e2283d84815cba053
01ccf114efd431d0cab9b3ef591d7f02
e76ff28a23af2fe37099c4e9a24c1e58
d7db8d42c476dfa69c15ce06d29bd863
642bf793695f412ed932f1ea4d9bc3f1
21761f6eb805546a561c9f036e85405b
author_id_fullname_str_mv 262d0cae7663ded863d6e2de15757f3c_***_Matthew Lawrence
97b3ad56338338453cbee42046817655_***_Ahmed Sabra
77c39404a9a98c6e2283d84815cba053_***_Karl Hawkins
01ccf114efd431d0cab9b3ef591d7f02_***_Lindsay D´Silva
e76ff28a23af2fe37099c4e9a24c1e58_***_Daniel Curtis
d7db8d42c476dfa69c15ce06d29bd863_***_Rowan Brown
642bf793695f412ed932f1ea4d9bc3f1_***_Rhodri Williams
21761f6eb805546a561c9f036e85405b_***_Adrian Evans
author Matthew Lawrence
Ahmed Sabra
Karl Hawkins
Lindsay D´Silva
Daniel Curtis
Rowan Brown
Rhodri Williams
Adrian Evans
author2 Matthew Lawrence
Ahmed Sabra
Gavin Mills
Suresh G. Pillai
Wendy Abdullah
Karl Hawkins
Roger H. K. Morris
Simon J. Davidson
Lindsay D´Silva
Daniel Curtis
Rowan Brown
John W. Weisel
Rhodri Williams
Adrian Evans
format Journal article
container_title British Journal of Haematology
container_volume 168
container_issue 4
container_start_page 571
publishDate 2015
institution Swansea University
issn 0007-1048
doi_str_mv 10.1111/bjh.13173
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.
published_date 2015-02-01T03:33:25Z
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