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Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis

Melitta McNarry Orcid Logo, Kelly Mackintosh Orcid Logo

PLOS ONE, Volume: 11, Issue: 3, Start page: e0151464

Swansea University Authors: Melitta McNarry Orcid Logo, Kelly Mackintosh Orcid Logo

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DOI (Published version): 10.1371/journal.pone.0151464

Abstract

Fundamental to the potential utilisation of heart rate variability (HRV) indices as a prognostic tool is the reproducibility of these measures. The purpose of the present study was therefore to investigate the reproducibility of 24-hour derived HRV indices in a clinical paediatric population. Eighte...

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ISSN: 1932-6203
Published: Public Library of Science (PLoS) 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa26957
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spelling 2020-10-22T18:18:46.3254941 v2 26957 2016-03-29 Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false bdb20e3f31bcccf95c7bc116070c4214 0000-0003-0355-6357 Kelly Mackintosh Kelly Mackintosh true false 2016-03-29 STSC Fundamental to the potential utilisation of heart rate variability (HRV) indices as a prognostic tool is the reproducibility of these measures. The purpose of the present study was therefore to investigate the reproducibility of 24-hour derived HRV indices in a clinical paediatric population. Eighteen children (10 boys; 12.4 ± 2.8 years) with mild to moderate Cystic Fibrosis (CF; FVC: 83 ± 12% predicted; FEV1: 80 ± 9% predicted) and eighteen age- and sex-matched controls (10 boys; 12.5 ± 2.7 years) wore a combined ECG and accelerometer for two consecutive days. Standard time and frequency domain indices of HRV were subsequently derived. Reproducibility was assessed by Bland-Altman plots, 95% limits of agreement and intra-class correlation coefficients (ICC). In both groups, there was no systematic difference between days, with the variables demonstrating a symmetrical, homoscedastic distribution around the zero line. The time domain parameters demonstrated a good to excellent reproducibility irrespective of the population considered (ICC: 0.56 to 0.86). In contrast, whilst the frequency domain parameters similarly showed excellent reproducibility in the healthy children (ICC: 0.70 to 0.96), the majority of the frequency domain parameters illustrated a poor to moderate reproducibility in those with CF (ICC: 0.22 to 0.43). The exceptions to this trend were the normalised LF and HF components which were associated with a good to excellent reproducibility. These findings thereby support the utilisation of time and relative frequency domain HRV indices as a prognostic tool in children with CF. Furthermore, the present results highlight the excellent reproducibility of HRV in healthy children, indicating that this may be a useful tool to assess intervention effectiveness in this population. Journal Article PLOS ONE 11 3 e0151464 Public Library of Science (PLoS) 1932-6203 11 3 2016 2016-03-11 10.1371/journal.pone.0151464 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2020-10-22T18:18:46.3254941 2016-03-29T15:44:28.1417014 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Melitta McNarry 0000-0003-0813-7477 1 Kelly Mackintosh 0000-0003-0355-6357 2 0026957-29032016154605.PDF Finalv3.PDF 2016-03-29T15:46:05.8630000 Output 229053 application/pdf Version of Record true 2016-03-29T00:00:00.0000000 Distributed under the terms of a Creative Commons Attribution 4.0 (CC-BY) Licence. true eng https://creativecommons.org/licenses/by/4.0/
title Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis
spellingShingle Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis
Melitta McNarry
Kelly Mackintosh
title_short Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis
title_full Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis
title_fullStr Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis
title_full_unstemmed Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis
title_sort Reproducibility of Heart Rate Variability Indices in Children with Cystic Fibrosis
author_id_str_mv 062f5697ff59f004bc8c713955988398
bdb20e3f31bcccf95c7bc116070c4214
author_id_fullname_str_mv 062f5697ff59f004bc8c713955988398_***_Melitta McNarry
bdb20e3f31bcccf95c7bc116070c4214_***_Kelly Mackintosh
author Melitta McNarry
Kelly Mackintosh
author2 Melitta McNarry
Kelly Mackintosh
format Journal article
container_title PLOS ONE
container_volume 11
container_issue 3
container_start_page e0151464
publishDate 2016
institution Swansea University
issn 1932-6203
doi_str_mv 10.1371/journal.pone.0151464
publisher Public Library of Science (PLoS)
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
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description Fundamental to the potential utilisation of heart rate variability (HRV) indices as a prognostic tool is the reproducibility of these measures. The purpose of the present study was therefore to investigate the reproducibility of 24-hour derived HRV indices in a clinical paediatric population. Eighteen children (10 boys; 12.4 ± 2.8 years) with mild to moderate Cystic Fibrosis (CF; FVC: 83 ± 12% predicted; FEV1: 80 ± 9% predicted) and eighteen age- and sex-matched controls (10 boys; 12.5 ± 2.7 years) wore a combined ECG and accelerometer for two consecutive days. Standard time and frequency domain indices of HRV were subsequently derived. Reproducibility was assessed by Bland-Altman plots, 95% limits of agreement and intra-class correlation coefficients (ICC). In both groups, there was no systematic difference between days, with the variables demonstrating a symmetrical, homoscedastic distribution around the zero line. The time domain parameters demonstrated a good to excellent reproducibility irrespective of the population considered (ICC: 0.56 to 0.86). In contrast, whilst the frequency domain parameters similarly showed excellent reproducibility in the healthy children (ICC: 0.70 to 0.96), the majority of the frequency domain parameters illustrated a poor to moderate reproducibility in those with CF (ICC: 0.22 to 0.43). The exceptions to this trend were the normalised LF and HF components which were associated with a good to excellent reproducibility. These findings thereby support the utilisation of time and relative frequency domain HRV indices as a prognostic tool in children with CF. Furthermore, the present results highlight the excellent reproducibility of HRV in healthy children, indicating that this may be a useful tool to assess intervention effectiveness in this population.
published_date 2016-03-11T03:32:33Z
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