Journal article 1682 views 400 downloads
Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker
M.A. Mohd Azmi,
Zari Tehrani 
,
R.P. Lewis,
K.-A.D. Walker,
D.R. Jones,
D.R. Daniels,
Shareen Doak ,
Owen Guy
,
R.P. Lewis,
K.-A.D. Walker,
D.R. Jones,
D.R. Daniels,
Shareen Doak ,
Owen Guy
Biosensors and Bioelectronics, Volume: 52, Pages: 216 - 224
Swansea University Authors:
Zari Tehrani , Shareen Doak , Owen Guy
-
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DOI (Published version): 10.1016/j.bios.2013.08.030
Abstract
In this article we present ultra-sensitive, silicon nanowire (SiNW)-based biosensor devices for the detection of disease biomarkers. An electrochemically induced functionalisation method has been employed to graft antibodies targeted against the prostate cancer risk biomarker 8-hydroxydeoxyguanosine...
| Published in: | Biosensors and Bioelectronics |
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| ISSN: | 0956-5663 |
| Published: |
2014
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa19740 |
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| Abstract: |
In this article we present ultra-sensitive, silicon nanowire (SiNW)-based biosensor devices for the detection of disease biomarkers. An electrochemically induced functionalisation method has been employed to graft antibodies targeted against the prostate cancer risk biomarker 8-hydroxydeoxyguanosine (8-OHdG) to SiNW surfaces. The antibody-functionalised SiNW sensor has been used to detect binding of the 8-OHdG biomarker to the SiNW surface within seconds of exposure. Detection of 8-OHdG concentrations as low as 1 ng/ml (3.5 nM) has been demonstrated. The active device has been bonded to a disposable printed circuit which can be inserted into an electronic readout system as part of an integrated Point of Care (POC) diagnostic. The speed, sensitivity and ease of detection of biomarkers using SiNW sensors render them ideal for eventual POC diagnostics. |
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| College: |
Faculty of Science and Engineering |
| Start Page: |
216 |
| End Page: |
224 |