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Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk

Emma Rees Orcid Logo, R. Coulson, F. Dunstan, W. D. Evans, H. L. Blundell, S. D. Luzio, G. Dunseath, J. P. Halcox, A. G. Fraser, D. A. Rees, Gareth Dunseath Orcid Logo, Steve Luzio Orcid Logo, Julian Halcox Orcid Logo

Human Reproduction, Volume: 29, Issue: 9, Pages: 2041 - 2049

Swansea University Authors: Emma Rees Orcid Logo, Gareth Dunseath Orcid Logo, Steve Luzio Orcid Logo, Julian Halcox Orcid Logo

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DOI (Published version): 10.1093/humrep/deu180

Abstract

Some studies have found that young women with polycystic ovary syndrome (PCOS) have increased measures of cardiovascular (CV) risk. However, PCOS is associated with insulin resistance (IR) and obesity which are themselves associated with increased risk of CV disease. Therefore in this population it...

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Published in: Human Reproduction
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa18319
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However, PCOS is associated with insulin resistance (IR) and obesity which are themselves associated with increased risk of CV disease. Therefore in this population it is difficult to establish how much of the risk is due to IR and obesity rather than PCOS per se and this may have implications for management of the syndrome. We conducted a cross-sectional study to determine whether subclinical CV dysfunction in young women with PCOS is independent of the effects of obesity. 84 women with PCOS (Rotterdam criteria) and 95 healthy volunteers (16-45 years) were enrolled in the study and underwent detailed assessment of body composition, endocrinology status, arterial and cardiac function. Methods included computed tomography assessment of visceral fat, arterial tonometry measures of stiffness, carotid ultrasound measures of intima-media thickness and echocardiographic measures of diastolic function. After adjustment for age and body mass index, PCOS subjects had greater insulin response following glucose challenge and higher testosterone levels but similar measures of arterial stiffness, carotid intima-media thickness and diastolic function. PCOS subjects had unexpectedy higher levels of high-molecular weight adiponectin (thought to be cardio-protective) but there was no significant relationship between adiponectin and arterial stiffness or diastolic function. Central arterial stiffness and diastolic dysfunction are associated with both IR and obesity in young women but PCOS does not appear to confer additional risk. Therefore obesity represents the greatest modifiable risk factor for CV disease in young women with PCOS and lifestyle measures which target weight reduction are critical in the management of the syndrome.</abstract><type>Journal Article</type><journal>Human Reproduction</journal><volume>29</volume><journalNumber>9</journalNumber><paginationStart>2041</paginationStart><paginationEnd>2049</paginationEnd><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic/><keywords>PCOS, insulin resistance, obesity, cardiovascular</keywords><publishedDay>17</publishedDay><publishedMonth>7</publishedMonth><publishedYear>2014</publishedYear><publishedDate>2014-07-17</publishedDate><doi>10.1093/humrep/deu180</doi><url/><notes/><college>COLLEGE NANME</college><department>Healthcare Science</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>HEAL</DepartmentCode><institution>Swansea University</institution><apcterm/><funders/><projectreference/><lastEdited>2023-06-26T16:56:14.4961541</lastEdited><Created>2014-09-07T11:22:57.5992301</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Emma</firstname><surname>Rees</surname><orcid>0000-0002-5373-1005</orcid><order>1</order></author><author><firstname>R.</firstname><surname>Coulson</surname><order>2</order></author><author><firstname>F.</firstname><surname>Dunstan</surname><order>3</order></author><author><firstname>W. 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spelling v2 18319 2014-09-07 Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk bbbbb83ad6562465984718fe10f47e47 0000-0002-5373-1005 Emma Rees Emma Rees true false fccbba9edcaee08a839a3c5cff8cbe19 0000-0001-6022-862X Gareth Dunseath Gareth Dunseath true false 01491e1cd582746a654fad9addf0de16 0000-0002-7206-6530 Steve Luzio Steve Luzio true false 3676f695eeda169d0f8c618adf27c04b 0000-0001-6926-2947 Julian Halcox Julian Halcox true false 2014-09-07 HEAL Some studies have found that young women with polycystic ovary syndrome (PCOS) have increased measures of cardiovascular (CV) risk. However, PCOS is associated with insulin resistance (IR) and obesity which are themselves associated with increased risk of CV disease. Therefore in this population it is difficult to establish how much of the risk is due to IR and obesity rather than PCOS per se and this may have implications for management of the syndrome. We conducted a cross-sectional study to determine whether subclinical CV dysfunction in young women with PCOS is independent of the effects of obesity. 84 women with PCOS (Rotterdam criteria) and 95 healthy volunteers (16-45 years) were enrolled in the study and underwent detailed assessment of body composition, endocrinology status, arterial and cardiac function. Methods included computed tomography assessment of visceral fat, arterial tonometry measures of stiffness, carotid ultrasound measures of intima-media thickness and echocardiographic measures of diastolic function. After adjustment for age and body mass index, PCOS subjects had greater insulin response following glucose challenge and higher testosterone levels but similar measures of arterial stiffness, carotid intima-media thickness and diastolic function. PCOS subjects had unexpectedy higher levels of high-molecular weight adiponectin (thought to be cardio-protective) but there was no significant relationship between adiponectin and arterial stiffness or diastolic function. Central arterial stiffness and diastolic dysfunction are associated with both IR and obesity in young women but PCOS does not appear to confer additional risk. Therefore obesity represents the greatest modifiable risk factor for CV disease in young women with PCOS and lifestyle measures which target weight reduction are critical in the management of the syndrome. Journal Article Human Reproduction 29 9 2041 2049 PCOS, insulin resistance, obesity, cardiovascular 17 7 2014 2014-07-17 10.1093/humrep/deu180 COLLEGE NANME Healthcare Science COLLEGE CODE HEAL Swansea University 2023-06-26T16:56:14.4961541 2014-09-07T11:22:57.5992301 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Emma Rees 0000-0002-5373-1005 1 R. Coulson 2 F. Dunstan 3 W. D. Evans 4 H. L. Blundell 5 S. D. Luzio 6 G. Dunseath 7 J. P. Halcox 8 A. G. Fraser 9 D. A. Rees 10 Gareth Dunseath 0000-0001-6022-862X 11 Steve Luzio 0000-0002-7206-6530 12 Julian Halcox 0000-0001-6926-2947 13
title Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk
spellingShingle Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk
Emma Rees
Gareth Dunseath
Steve Luzio
Julian Halcox
title_short Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk
title_full Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk
title_fullStr Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk
title_full_unstemmed Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk
title_sort Central arterial stiffness and diastolic function are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk
author_id_str_mv bbbbb83ad6562465984718fe10f47e47
fccbba9edcaee08a839a3c5cff8cbe19
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author_id_fullname_str_mv bbbbb83ad6562465984718fe10f47e47_***_Emma Rees
fccbba9edcaee08a839a3c5cff8cbe19_***_Gareth Dunseath
01491e1cd582746a654fad9addf0de16_***_Steve Luzio
3676f695eeda169d0f8c618adf27c04b_***_Julian Halcox
author Emma Rees
Gareth Dunseath
Steve Luzio
Julian Halcox
author2 Emma Rees
R. Coulson
F. Dunstan
W. D. Evans
H. L. Blundell
S. D. Luzio
G. Dunseath
J. P. Halcox
A. G. Fraser
D. A. Rees
Gareth Dunseath
Steve Luzio
Julian Halcox
format Journal article
container_title Human Reproduction
container_volume 29
container_issue 9
container_start_page 2041
publishDate 2014
institution Swansea University
doi_str_mv 10.1093/humrep/deu180
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
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description Some studies have found that young women with polycystic ovary syndrome (PCOS) have increased measures of cardiovascular (CV) risk. However, PCOS is associated with insulin resistance (IR) and obesity which are themselves associated with increased risk of CV disease. Therefore in this population it is difficult to establish how much of the risk is due to IR and obesity rather than PCOS per se and this may have implications for management of the syndrome. We conducted a cross-sectional study to determine whether subclinical CV dysfunction in young women with PCOS is independent of the effects of obesity. 84 women with PCOS (Rotterdam criteria) and 95 healthy volunteers (16-45 years) were enrolled in the study and underwent detailed assessment of body composition, endocrinology status, arterial and cardiac function. Methods included computed tomography assessment of visceral fat, arterial tonometry measures of stiffness, carotid ultrasound measures of intima-media thickness and echocardiographic measures of diastolic function. After adjustment for age and body mass index, PCOS subjects had greater insulin response following glucose challenge and higher testosterone levels but similar measures of arterial stiffness, carotid intima-media thickness and diastolic function. PCOS subjects had unexpectedy higher levels of high-molecular weight adiponectin (thought to be cardio-protective) but there was no significant relationship between adiponectin and arterial stiffness or diastolic function. Central arterial stiffness and diastolic dysfunction are associated with both IR and obesity in young women but PCOS does not appear to confer additional risk. Therefore obesity represents the greatest modifiable risk factor for CV disease in young women with PCOS and lifestyle measures which target weight reduction are critical in the management of the syndrome.
published_date 2014-07-17T16:56:09Z
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