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Production of Specialized Metabolites by Streptomyces coelicolor A3(2)

Geertje Van Keulen Orcid Logo, Paul J. Dyson

Volume: 89, Pages: 217 - 266

Swansea University Author: Geertje Van Keulen Orcid Logo

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DOI (Published version): 10.1016/B978-0-12-800259-9.00006-8

Abstract

The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes...

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Published: Elsevier Inc 2014
Online Access: http://www.sciencedirect.com/science/article/pii/B9780128002599000068
URI: https://cronfa.swan.ac.uk/Record/cronfa18259
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first_indexed 2014-08-21T01:58:13Z
last_indexed 2018-02-09T04:52:42Z
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spelling 2014-08-20T14:05:25.2896892 v2 18259 2014-08-20 Production of Specialized Metabolites by Streptomyces coelicolor A3(2) 6b2c798924ac19de63e2168d50b99425 0000-0002-6044-1575 Geertje Van Keulen Geertje Van Keulen true false 2014-08-20 BMS The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes has highlighted further how proficient these bacteria are in specialized metabolism, which have been largely underexploited in traditional screening programs. The genome sequence of the model strain Streptomyces coelicolor A3(2), and subsequent development of genomics-driven approaches to understand its large specialized metabolome, has been key in unlocking the high potential of specialized metabolites for natural product genomics-based drug discovery. This review discusses systematically the biochemistry and genetics of each of the specialized metabolites of S. coelicolor and describes metabolite transport processes for excretion and complex regulatory patterns controlling biosynthesis.© 2014 Elsevier Inc. All rights reserved. Book chapter 89 217 266 Elsevier Inc Streptomyces coelicolor, specialized metabolism, natural products, biosynthesis, gene clusters, antibiotics, regulation, modulation, host, secondary metabolism 14 8 2014 2014-08-14 10.1016/B978-0-12-800259-9.00006-8 http://www.sciencedirect.com/science/article/pii/B9780128002599000068 - COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2014-08-20T14:05:25.2896892 2014-08-20T14:01:52.6311328 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Geertje Van Keulen 0000-0002-6044-1575 1 Paul J. Dyson 2
title Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
spellingShingle Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
Geertje Van Keulen
title_short Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
title_full Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
title_fullStr Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
title_full_unstemmed Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
title_sort Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
author_id_str_mv 6b2c798924ac19de63e2168d50b99425
author_id_fullname_str_mv 6b2c798924ac19de63e2168d50b99425_***_Geertje Van Keulen
author Geertje Van Keulen
author2 Geertje Van Keulen
Paul J. Dyson
format Book chapter
container_volume 89
container_start_page 217
publishDate 2014
institution Swansea University
doi_str_mv 10.1016/B978-0-12-800259-9.00006-8
publisher Elsevier Inc
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.sciencedirect.com/science/article/pii/B9780128002599000068
document_store_str 0
active_str 0
description The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes has highlighted further how proficient these bacteria are in specialized metabolism, which have been largely underexploited in traditional screening programs. The genome sequence of the model strain Streptomyces coelicolor A3(2), and subsequent development of genomics-driven approaches to understand its large specialized metabolome, has been key in unlocking the high potential of specialized metabolites for natural product genomics-based drug discovery. This review discusses systematically the biochemistry and genetics of each of the specialized metabolites of S. coelicolor and describes metabolite transport processes for excretion and complex regulatory patterns controlling biosynthesis.© 2014 Elsevier Inc. All rights reserved.
published_date 2014-08-14T03:21:22Z
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score 11.037056

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