Book chapter 1725 views
Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
Geertje Van Keulen 
,
Paul J. Dyson
,
Paul J. Dyson
Volume: 89, Pages: 217 - 266
Swansea University Author:
Geertje Van Keulen
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DOI (Published version): 10.1016/B978-0-12-800259-9.00006-8
Abstract
The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes...
| Published: |
Elsevier Inc
2014
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| Online Access: |
http://www.sciencedirect.com/science/article/pii/B9780128002599000068 |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa18259 |
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| Abstract: |
The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes has highlighted further how proficient these bacteria are in specialized metabolism, which have been largely underexploited in traditional screening programs. The genome sequence of the model strain Streptomyces coelicolor A3(2), and subsequent development of genomics-driven approaches to understand its large specialized metabolome, has been key in unlocking the high potential of specialized metabolites for natural product genomics-based drug discovery. This review discusses systematically the biochemistry and genetics of each of the specialized metabolites of S. coelicolor and describes metabolite transport processes for excretion and complex regulatory patterns controlling biosynthesis.© 2014 Elsevier Inc. All rights reserved. |
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| Item Description: |
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| Keywords: |
Streptomyces coelicolor, specialized metabolism, natural products, biosynthesis, gene clusters, antibiotics, regulation, modulation, host, secondary metabolism |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Start Page: |
217 |
| End Page: |
266 |