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Synthesis of the Asperparaline Core by a Radical Cascade

Peter Crick, Nigel S Simpkins, Adrian Highton

Organic Letters, Volume: 13, Issue: 24, Pages: 6472 - 6475

Swansea University Author: Peter Crick

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DOI (Published version): 10.1021/ol202769f

Abstract

A concise access to the pentacyclic core structure of the asperparalines is described. The key step is a radical cascade sequence comprised of a 1,6-hydrogen atom transfer followed by 6-exo-trig and 5-exo-trig cyclizations.

Published in: Organic Letters
ISSN: 1523-7060 1523-7052
Published: 2011
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URI: https://cronfa.swan.ac.uk/Record/cronfa15144
Abstract: A concise access to the pentacyclic core structure of the asperparalines is described. The key step is a radical cascade sequence comprised of a 1,6-hydrogen atom transfer followed by 6-exo-trig and 5-exo-trig cyclizations.
College: Faculty of Medicine, Health and Life Sciences
Issue: 24
Start Page: 6472
End Page: 6475