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A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Alexander Mazein, Steven Watterson, Wei-Yuan Hsieh, William Griffiths Orcid Logo, Peter Ghazal

Biochemical Pharmacology

Swansea University Author: William Griffiths Orcid Logo

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DOI (Published version): 10.1016/j.bcp.2013.03.021

Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here...

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Published in: Biochemical Pharmacology
ISSN: 0006-2952
Published: 2013
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URI: https://cronfa.swan.ac.uk/Record/cronfa14862
first_indexed 2013-07-23T12:13:01Z
last_indexed 2018-02-09T04:46:30Z
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spelling 2013-05-22T10:29:00.5760993 v2 14862 2013-05-22 A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2013-05-22 MEDS Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format. Journal Article Biochemical Pharmacology 0006-2952 31 12 2013 2013-12-31 10.1016/j.bcp.2013.03.021 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2013-05-22T10:29:00.5760993 2013-05-22T10:29:00.5790291 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Alexander Mazein 1 Steven Watterson 2 Wei-Yuan Hsieh 3 William Griffiths 0000-0002-4129-6616 4 Peter Ghazal 5
title A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
spellingShingle A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
William Griffiths
title_short A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_full A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_fullStr A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_full_unstemmed A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_sort A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author William Griffiths
author2 Alexander Mazein
Steven Watterson
Wei-Yuan Hsieh
William Griffiths
Peter Ghazal
format Journal article
container_title Biochemical Pharmacology
publishDate 2013
institution Swansea University
issn 0006-2952
doi_str_mv 10.1016/j.bcp.2013.03.021
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
published_date 2013-12-31T18:31:06Z
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score 10.841611

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