Journal article 1133 views
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
Alexander Mazein,
Steven Watterson,
Wei-Yuan Hsieh,
William Griffiths 
,
Peter Ghazal
,
Peter Ghazal
Biochemical Pharmacology
Swansea University Author:
William Griffiths
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DOI (Published version): 10.1016/j.bcp.2013.03.021
Abstract
Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here...
| Published in: | Biochemical Pharmacology |
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| ISSN: | 0006-2952 |
| Published: |
2013
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa14862 |
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| Abstract: |
Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format. |
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| College: |
Faculty of Medicine, Health and Life Sciences |