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Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users

Adrian P Burgess, Louise Venables, Helena Jones, Rhiannon Edwards, Andrew Parrott

Psychopharmacology, Volume: 216, Issue: 4, Pages: 545 - 556

Swansea University Author: Andrew Parrott

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DOI (Published version): 10.1007/s00213-011-2249-9

Abstract

Ecstasy is a recreational drug whose active ingredient, 3,4 Methylenedioxymethamphetamine (MDMA), acts predominantly on the serotonergic system. Although MDMA is known to be neurotoxic in animals, the long-term effects of recreational Ecstasy use in humans remain controversial but one commonly repor...

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Published in: Psychopharmacology
ISSN: 0033-3158 1432-2072
Published: 2011
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URI: https://cronfa.swan.ac.uk/Record/cronfa9309
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spelling 2015-05-14T15:54:28.9002015 v2 9309 2012-03-19 Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users 3c706e6f0763eeaf11b0cc8b37d6757f Andrew Parrott Andrew Parrott true false 2012-03-19 HPS Ecstasy is a recreational drug whose active ingredient, 3,4 Methylenedioxymethamphetamine (MDMA), acts predominantly on the serotonergic system. Although MDMA is known to be neurotoxic in animals, the long-term effects of recreational Ecstasy use in humans remain controversial but one commonly reported consequence is mild cognitive impairment particularly affecting verbal episodic memory. Although event-related potentials (ERPs) have made significant contributions to our understanding of human memory processes, until now they have not been applied to study the long term effects of Ecstasy. The aim of this study was to examine the effects of past Ecstasy use on recognition memory for both verbal and non-verbal stimuli using ERPs. We compared the ERPs of abstinent Ecstasy usersEcstasy/polydrug users with those of matched groups of cannabis users and non-drug using controls. Despite equivalent memory performance, Ecstasy usersEcstasy/polydrug users showed an attenuated late positivity over left-parietal scalp sites, a component associated with the specific memory process of recollection. This effect was only found in the word recognition task which is consistent with evidence that left hemisphere cognitive functions are disproportionately affected by Ecstasy, probably because the serotonergic system is laterally asymmetrical. Experimentally decreasing central serotonergic activity through acute tryptophan depletion also selectively impairs recollection, and this too suggests the importance of the serotonergic system. Overall, our results suggest that Ecstasy has a durable effect on a specific component of recognition memory, recollection, and that this is most probably caused by the serotonergic neurotoxicity of MDMA although the role of other drugs cannot be excluded. Journal Article Psychopharmacology 216 4 545 556 0033-3158 1432-2072 31 8 2011 2011-08-31 10.1007/s00213-011-2249-9 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2015-05-14T15:54:28.9002015 2012-03-19T09:20:56.0019026 Faculty of Medicine, Health and Life Sciences School of Psychology Adrian P Burgess 1 Louise Venables 2 Helena Jones 3 Rhiannon Edwards 4 Andrew Parrott 5
title Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users
spellingShingle Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users
Andrew Parrott
title_short Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users
title_full Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users
title_fullStr Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users
title_full_unstemmed Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users
title_sort Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine (“Ecstasy”)/polydrug users
author_id_str_mv 3c706e6f0763eeaf11b0cc8b37d6757f
author_id_fullname_str_mv 3c706e6f0763eeaf11b0cc8b37d6757f_***_Andrew Parrott
author Andrew Parrott
author2 Adrian P Burgess
Louise Venables
Helena Jones
Rhiannon Edwards
Andrew Parrott
format Journal article
container_title Psychopharmacology
container_volume 216
container_issue 4
container_start_page 545
publishDate 2011
institution Swansea University
issn 0033-3158
1432-2072
doi_str_mv 10.1007/s00213-011-2249-9
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 0
active_str 0
description Ecstasy is a recreational drug whose active ingredient, 3,4 Methylenedioxymethamphetamine (MDMA), acts predominantly on the serotonergic system. Although MDMA is known to be neurotoxic in animals, the long-term effects of recreational Ecstasy use in humans remain controversial but one commonly reported consequence is mild cognitive impairment particularly affecting verbal episodic memory. Although event-related potentials (ERPs) have made significant contributions to our understanding of human memory processes, until now they have not been applied to study the long term effects of Ecstasy. The aim of this study was to examine the effects of past Ecstasy use on recognition memory for both verbal and non-verbal stimuli using ERPs. We compared the ERPs of abstinent Ecstasy usersEcstasy/polydrug users with those of matched groups of cannabis users and non-drug using controls. Despite equivalent memory performance, Ecstasy usersEcstasy/polydrug users showed an attenuated late positivity over left-parietal scalp sites, a component associated with the specific memory process of recollection. This effect was only found in the word recognition task which is consistent with evidence that left hemisphere cognitive functions are disproportionately affected by Ecstasy, probably because the serotonergic system is laterally asymmetrical. Experimentally decreasing central serotonergic activity through acute tryptophan depletion also selectively impairs recollection, and this too suggests the importance of the serotonergic system. Overall, our results suggest that Ecstasy has a durable effect on a specific component of recognition memory, recollection, and that this is most probably caused by the serotonergic neurotoxicity of MDMA although the role of other drugs cannot be excluded.
published_date 2011-08-31T03:11:14Z
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