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Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection

K. A Zaghloul, C. T Weidemann, B. C Lega, J. L Jaggi, G. H Baltuch, M. J Kahana, Christoph Weidemann

Journal of Neuroscience, Volume: 32, Issue: 7, Pages: 2453 - 2460

Swansea University Author: Christoph Weidemann

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DOI (Published version): 10.1523/JNEUROSCI.5815-11.2012

Abstract

The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with the inhibitory pathways of the basal ganglia, is well positioned to efficiently mediate action selection. Here, we use microelectrode recordings captured during deep brain stimulation surg...

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Published in: Journal of Neuroscience
ISSN: 0270-6474 1529-2401
Published: 2012
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URI: https://cronfa.swan.ac.uk/Record/cronfa8382
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last_indexed 2019-06-12T19:19:36Z
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spelling 2019-06-12T15:23:57.6076732 v2 8382 2012-02-23 Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection b155eeefe08155214e70fea25649223c Christoph Weidemann Christoph Weidemann true false 2012-02-23 FGMHL The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with the inhibitory pathways of the basal ganglia, is well positioned to efficiently mediate action selection. Here, we use microelectrode recordings captured during deep brain stimulation surgery as participants engage in a decision task to examine the role of the human STN in action selection. We demonstrate that spiking activity in the STN increases when participants engage in a decision and that the level of spiking activity increases with the degree of decision conflict. These data implicate the STN as an important mediator of action selection during decision processes. Journal Article Journal of Neuroscience 32 7 2453 2460 0270-6474 1529-2401 15 2 2012 2012-02-15 10.1523/JNEUROSCI.5815-11.2012 http://cogsci.info/papers/ZaghloulEtAl2012.pdf COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2019-06-12T15:23:57.6076732 2012-02-23T10:44:16.3670000 Faculty of Medicine, Health and Life Sciences School of Psychology K. A Zaghloul 1 C. T Weidemann 2 B. C Lega 3 J. L Jaggi 4 G. H Baltuch 5 M. J Kahana 6 Christoph Weidemann 7 0008382-23022012104612.pdf ZaghloulEtAl2012.pdf 2012-02-23T10:46:12.0570000 Output 617687 Version of Record true 2012-02-23T00:00:00.0000000 true
title Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection
spellingShingle Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection
Christoph Weidemann
title_short Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection
title_full Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection
title_fullStr Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection
title_full_unstemmed Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection
title_sort Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection
author_id_str_mv b155eeefe08155214e70fea25649223c
author_id_fullname_str_mv b155eeefe08155214e70fea25649223c_***_Christoph Weidemann
author Christoph Weidemann
author2 K. A Zaghloul
C. T Weidemann
B. C Lega
J. L Jaggi
G. H Baltuch
M. J Kahana
Christoph Weidemann
format Journal article
container_title Journal of Neuroscience
container_volume 32
container_issue 7
container_start_page 2453
publishDate 2012
institution Swansea University
issn 0270-6474
1529-2401
doi_str_mv 10.1523/JNEUROSCI.5815-11.2012
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
url http://cogsci.info/papers/ZaghloulEtAl2012.pdf
document_store_str 1
active_str 0
description The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with the inhibitory pathways of the basal ganglia, is well positioned to efficiently mediate action selection. Here, we use microelectrode recordings captured during deep brain stimulation surgery as participants engage in a decision task to examine the role of the human STN in action selection. We demonstrate that spiking activity in the STN increases when participants engage in a decision and that the level of spiking activity increases with the degree of decision conflict. These data implicate the STN as an important mediator of action selection during decision processes.
published_date 2012-02-15T03:10:30Z
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score 11.037581

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