No Cover Image

Journal article 107 views

Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications

Martin Gill Orcid Logo

RSC Medicinal Chemistry

Swansea University Author: Martin Gill Orcid Logo

  • 71858.VoR.pdf

    PDF | Version of Record

    This article is licensed under the terms of a Creative Commons Attribution 3.0 Unported licence.

    Download (2.64MB)

Check full text

DOI (Published version): 10.1039/d6md00154h

Abstract

Ruthenium(II) polypyridyl complexes (RPCs) have generated substantial interest due to their biomolecular binding capabilities, favourable photophysical properties, and anticancer activity. DNA is widely reported as a target for RPCs, and their recent development as photosensitisers for photodynamic...

Full description

Published in: RSC Medicinal Chemistry
ISSN: 2632-8682
Published: Royal Society of Chemistry (RSC) 2026
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa71858
first_indexed 2026-05-06T14:14:23Z
last_indexed 2026-05-29T11:49:37Z
id cronfa71858
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2026-05-28T15:56:26.6494891</datestamp><bib-version>v2</bib-version><id>71858</id><entry>2026-05-06</entry><title>Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications</title><swanseaauthors><author><sid>485d85b532851e8863cd19c6af7e00f7</sid><ORCID>0000-0002-1371-5676</ORCID><firstname>Martin</firstname><surname>Gill</surname><name>Martin Gill</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2026-05-06</date><deptcode>EAAS</deptcode><abstract>Ruthenium(II) polypyridyl complexes (RPCs) have generated substantial interest due to their biomolecular binding capabilities, favourable photophysical properties, and anticancer activity. DNA is widely reported as a target for RPCs, and their recent development as photosensitisers for photodynamic therapy further emphasises DNA damage as a key biological outcome. The aim of this review is to highlight recent studies in the design of RPCs as pharmacological DNA-targeting agents and describe what is known about their impact on the DNA damage response (DDR). This, in turn, provides insight into the nature of the DNA lesions induced by these complexes. The relationship between binding mode, activation of specific DDR pathways, and resultant cell fate in human cancer cell lines is examined and, where appropriate, placed in a therapeutic context. Implications for enhancing cancer selectivity, including the use of RPCs alongside DDR inhibitors in combination strategies, as well as associated safety considerations, are discussed.</abstract><type>Journal Article</type><journal>RSC Medicinal Chemistry</journal><volume>0</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Royal Society of Chemistry (RSC)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2632-8682</issnElectronic><keywords/><publishedDay>6</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2026</publishedYear><publishedDate>2026-05-06</publishedDate><doi>10.1039/d6md00154h</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders/><projectreference/><lastEdited>2026-05-28T15:56:26.6494891</lastEdited><Created>2026-05-06T15:09:57.8271892</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Chemistry</level></path><authors><author><firstname>Martin</firstname><surname>Gill</surname><orcid>0000-0002-1371-5676</orcid><order>1</order></author></authors><documents><document><filename>71858__36833__8bd0ff7fd98e49968efa17ac8b69d37a.pdf</filename><originalFilename>71858.VoR.pdf</originalFilename><uploaded>2026-05-28T15:54:56.3623622</uploaded><type>Output</type><contentLength>2766894</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>This article is licensed under the terms of a Creative Commons Attribution 3.0 Unported licence.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/3.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2026-05-28T15:56:26.6494891 v2 71858 2026-05-06 Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications 485d85b532851e8863cd19c6af7e00f7 0000-0002-1371-5676 Martin Gill Martin Gill true false 2026-05-06 EAAS Ruthenium(II) polypyridyl complexes (RPCs) have generated substantial interest due to their biomolecular binding capabilities, favourable photophysical properties, and anticancer activity. DNA is widely reported as a target for RPCs, and their recent development as photosensitisers for photodynamic therapy further emphasises DNA damage as a key biological outcome. The aim of this review is to highlight recent studies in the design of RPCs as pharmacological DNA-targeting agents and describe what is known about their impact on the DNA damage response (DDR). This, in turn, provides insight into the nature of the DNA lesions induced by these complexes. The relationship between binding mode, activation of specific DDR pathways, and resultant cell fate in human cancer cell lines is examined and, where appropriate, placed in a therapeutic context. Implications for enhancing cancer selectivity, including the use of RPCs alongside DDR inhibitors in combination strategies, as well as associated safety considerations, are discussed. Journal Article RSC Medicinal Chemistry 0 Royal Society of Chemistry (RSC) 2632-8682 6 5 2026 2026-05-06 10.1039/d6md00154h COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University SU Library paid the OA fee (TA Institutional Deal) 2026-05-28T15:56:26.6494891 2026-05-06T15:09:57.8271892 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Martin Gill 0000-0002-1371-5676 1 71858__36833__8bd0ff7fd98e49968efa17ac8b69d37a.pdf 71858.VoR.pdf 2026-05-28T15:54:56.3623622 Output 2766894 application/pdf Version of Record true This article is licensed under the terms of a Creative Commons Attribution 3.0 Unported licence. true eng http://creativecommons.org/licenses/by/3.0/
title Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications
spellingShingle Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications
Martin Gill
title_short Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications
title_full Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications
title_fullStr Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications
title_full_unstemmed Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications
title_sort Ruthenium(ii) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications
author_id_str_mv 485d85b532851e8863cd19c6af7e00f7
author_id_fullname_str_mv 485d85b532851e8863cd19c6af7e00f7_***_Martin Gill
author Martin Gill
author2 Martin Gill
format Journal article
container_title RSC Medicinal Chemistry
container_volume 0
publishDate 2026
institution Swansea University
issn 2632-8682
doi_str_mv 10.1039/d6md00154h
publisher Royal Society of Chemistry (RSC)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
document_store_str 1
active_str 0
description Ruthenium(II) polypyridyl complexes (RPCs) have generated substantial interest due to their biomolecular binding capabilities, favourable photophysical properties, and anticancer activity. DNA is widely reported as a target for RPCs, and their recent development as photosensitisers for photodynamic therapy further emphasises DNA damage as a key biological outcome. The aim of this review is to highlight recent studies in the design of RPCs as pharmacological DNA-targeting agents and describe what is known about their impact on the DNA damage response (DDR). This, in turn, provides insight into the nature of the DNA lesions induced by these complexes. The relationship between binding mode, activation of specific DDR pathways, and resultant cell fate in human cancer cell lines is examined and, where appropriate, placed in a therapeutic context. Implications for enhancing cancer selectivity, including the use of RPCs alongside DDR inhibitors in combination strategies, as well as associated safety considerations, are discussed.
published_date 2026-05-06T17:20:33Z
_version_ 1866630989911949312
score 11.106612

Similar Items