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Use of the GTT@home Oral Glucose Tolerance Test Kit in Gestational Diabetes Mellitus: Performance Evaluation Study
,
Steve Luzio ,
Ivy Cheung,
Sharon Parsons ,
Nicola John ,
Mahmoud Chokor ,
Michael Atkinson ,
Rajesh Peter
JMIR Diabetes, Volume: 11, Pages: e69695 - e69695
Swansea University Authors:
Gareth Dunseath , Steve Luzio , Ivy Cheung, Sharon Parsons
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© Gareth J Dunseath, Stephen D Luzio, Wai Yee Cheung, Sharon N Parsons, Nicola John, Mahmoud Chokor, Michael Atkinson, Rajesh Peter. This is an open access article distributed under the terms of the Creative Commons Attribution License.
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DOI (Published version): 10.2196/69695
Abstract
Background:The 75-g oral glucose tolerance test (OGTT) remains the optimal diagnostic test for use in pregnancy but needs to be performed in the clinical setting. The GTT@home OGTT device offers the potential to enable patients to perform the test at home using capillary blood samples.Objective:This...
| Published in: | JMIR Diabetes |
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| ISSN: | 2371-4379 |
| Published: |
JMIR Publications Inc.
2026
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa71418 |
| Abstract: |
Background:The 75-g oral glucose tolerance test (OGTT) remains the optimal diagnostic test for use in pregnancy but needs to be performed in the clinical setting. The GTT@home OGTT device offers the potential to enable patients to perform the test at home using capillary blood samples.Objective:This study aimed to determine the accuracy of the GTT@home device compared to the routine National Health Service laboratory reference method using blood samples during an OGTT from pregnant women at high risk of developing gestational diabetes mellitus (GDM).Methods:A total of 65 women (aged >18 y), at high risk for GDM (per the National Institute for Health and Care Excellence guidelines) were recruited for this performance evaluation. Following an overnight fast, participants went for a 75-g OGTT. Fasting and 2-hour capillary glucose levels were measured using the GTT@home device with corresponding venous samples measured in the laboratory.Results:The complete data for analysis was available for 61/65 devices. The overall bias for the GTT@home device was +0.16 mmol/L. Correlation analysis of the clinical performance of the two methods using a surveillance error grid showed 79.8% of results in the lowest, 16.9% in the “slight, lower” and 2.4% in the “slight, higher” risk categories. Only 0.8% were “moderate, lower” risk, and none were in any higher risk categories. There was agreement in the classification in 54/61 cases. The GTT@home device under-classified 2 cases and over-classified 5 cases.Conclusions:The GTT@home device worked well in a controlled, antenatal clinical setting. Differences in classification observed were generally due to small differences in glucose values close to the diagnostic cut-offs. The GTT@home device shows promise for home testing of glucose tolerance in pregnant women. |
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| Keywords: |
device; diagnosis; gestational diabetes; OGTT; glucose; oral glucose tolerance test |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This clinical study was funded by Digostics Ltd. |
| Start Page: |
e69695 |
| End Page: |
e69695 |