Journal article 87 views
Comparative Responsiveness of Preference-Based Health-Related Quality of Life, Social Care, and Well-Being Measures in the Context of Multiple Sclerosis
Elizabeth Goodwin,
Amy Heather,
Nia Morrish,
Jenny Freeman,
Kate Boddy,
Sarah Thomas,
Jeremy Chataway,
Rod Middleton 
,
Annie Hawton
,
Annie Hawton
Value in Health
Swansea University Author:
Rod Middleton
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1016/j.jval.2025.09.3063
Abstract
To provide evidence on the responsiveness of social care and wellbeing preference-based measures (PBMs) compared to health-related quality of life PBMs in the context of multiple sclerosis (MS). The ICEpop CAPability measure for Adults (ICECAP-A) and Adult Social Care Outcomes Toolkit (ASCOT) were c...
| Published in: | Value in Health |
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| ISSN: | 1098-3015 1524-4733 |
| Published: |
Elsevier BV
2025
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa70796 |
| Abstract: |
To provide evidence on the responsiveness of social care and wellbeing preference-based measures (PBMs) compared to health-related quality of life PBMs in the context of multiple sclerosis (MS). The ICEpop CAPability measure for Adults (ICECAP-A) and Adult Social Care Outcomes Toolkit (ASCOT) were completed online in September 2019, March 2020, September 2020, via the UK MS Register. Responses were linked to EQ-5D-3L and MS Impact Scale-Eight Dimensions (MSIS-8D) values, and to MS Walking Scale-12 (MSWS-12), Hospital Anxiety and Depression Scale (HADS) and Fatigue Severity Scale (FSS) scores. Responsiveness was assessed in relation to minimal important differences on MSWS-12, HADS and FSS between timepoints, using mean change scores, t-tests, standardised effect sizes, standardised response means and multivariable regression analyses. Data from 1,742 people with MS were available for analysis. When using standardised values, MSIS-8D showed the greatest responsiveness and EQ-5D-3L the least. In contrast, when absolute utility values were used, EQ-5D-3L performed similarly to MSIS-8D and better than ICECAP-A and ASCOT. Standardised regression analyses indicated the MSIS-8Ds to be the most responsive, followed by the ASCOT, ICECAP-A, and EQ-5D-3L. The ICECAP-A, ASCOT and MSIS-8D were more responsive than the EQ-5D-3L in the context of MS when compared using standardised scores. The increased responsiveness of EQ-5D-3L when absolute values were used seems an artefact of the wide-ranging scale of this measure. This illustrates how the maximum potential range of values for a given PBM tariff could influence whether an intervention is found to be cost-effective. |
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| Keywords: |
Preference-based measures; Responsiveness; EQ-5DWellbeing measures; Social care related quality of life measures; Health-related quality of life measures; QALY measures |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This work was supported by Grant 82 from the UK Multiple Sclerosis Society. |