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Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records

Arron Lacey Orcid Logo, Carys Jones, SEUNG RYOO, Jacqueline Stephen Orcid Logo, Christopher J. Weir Orcid Logo, Owen Pickrell Orcid Logo, Richard F. Chin

Seizure: European Journal of Epilepsy, Volume: 122, Pages: 52 - 57

Swansea University Authors: Arron Lacey Orcid Logo, Carys Jones, SEUNG RYOO, Owen Pickrell Orcid Logo

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DOI (Published version): 10.1016/j.seizure.2024.09.008

Abstract

Background and objectiveInformation on self-limited epilepsy with centrotemporal spikes (SeLECTS) epidemiology is limited. We aimed to determine the incidence of SeLECTS in children, its association with socioeconomic deprivation and the prevalence of neurodevelopmental comorbidities.MethodWe perfor...

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Published in: Seizure: European Journal of Epilepsy
ISSN: 1059-1311
Published: Elsevier BV 2024
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We aimed to determine the incidence of SeLECTS in children, its association with socioeconomic deprivation and the prevalence of neurodevelopmental comorbidities.MethodWe performed a retrospective cohort study (2004&#x2013;2017) using anonymised, linked, routinely collected, primary care and demographic data for children in Wales. We used primary care diagnosis codes to identify children (aged 0&#x2013;16 years) with SeLECTS and other epilepsies and to record antiseizure medication (ASM) prescriptions and neurodevelopmental comorbidities. We used a mixed effects Poisson regression model to determine temporal trends of SeLECTS incidence and its association with socioeconomic deprivation.ResultsWe identified 6,732 children with epilepsy, 186 (3%) with SeLECTS. In 2017, epilepsy and SeLECTS prevalence was 0.55% and 0.02% respectively with corresponding crude incidence of 51.2/100,000/year and 1.1/100,000/year. The incidence of epilepsy in children decreased with decreasing deprivation with an adjusted incidence rate ratio (AIRR) of 0.72 (95% CI 0.64&#x2013;0.82) in the least deprived compared with the most deprived quintile. The corresponding AIRR for children with SeLECTS was 1.35 (95% CI 0.46&#x2013;1.99). 34% of children with epilepsy, 18% of children with SeLECTS and 3% of all children in Wales had a neurodevelopmental disorder and or school problems. Half of children with SeLECTS were treated with ASM.ConclusionsWe identified a lower than previously reported incidence of SeLECTS, which may be due to under-recording of SeLECTS. There was no change in the incidence of SeLECTS over time, whilst the incidence of childhood epilepsy overall was decreasing. There was no significant association between incidence of SeLECTS and deprivation but the modest sample size needs to be considered. Children with SeLECTS should be screened for neurodevelopmental and or learning comorbidities. 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spelling 2025-12-05T14:52:12.1829103 v2 70664 2025-10-14 Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records b69d245574e754d2637cc9e76379fe11 0000-0001-7983-8073 Arron Lacey Arron Lacey true false 76dda5f486b0236c893f46dfb9fa2cd0 Carys Jones Carys Jones true false 7909cc4a8fc3bfcb8c8c2e0e0d9933c3 SEUNG RYOO SEUNG RYOO true false 1c3044b5ff7a6552ff5e8c9e3901c807 0000-0003-4396-5657 Owen Pickrell Owen Pickrell true false 2025-10-14 MEDS Background and objectiveInformation on self-limited epilepsy with centrotemporal spikes (SeLECTS) epidemiology is limited. We aimed to determine the incidence of SeLECTS in children, its association with socioeconomic deprivation and the prevalence of neurodevelopmental comorbidities.MethodWe performed a retrospective cohort study (2004–2017) using anonymised, linked, routinely collected, primary care and demographic data for children in Wales. We used primary care diagnosis codes to identify children (aged 0–16 years) with SeLECTS and other epilepsies and to record antiseizure medication (ASM) prescriptions and neurodevelopmental comorbidities. We used a mixed effects Poisson regression model to determine temporal trends of SeLECTS incidence and its association with socioeconomic deprivation.ResultsWe identified 6,732 children with epilepsy, 186 (3%) with SeLECTS. In 2017, epilepsy and SeLECTS prevalence was 0.55% and 0.02% respectively with corresponding crude incidence of 51.2/100,000/year and 1.1/100,000/year. The incidence of epilepsy in children decreased with decreasing deprivation with an adjusted incidence rate ratio (AIRR) of 0.72 (95% CI 0.64–0.82) in the least deprived compared with the most deprived quintile. The corresponding AIRR for children with SeLECTS was 1.35 (95% CI 0.46–1.99). 34% of children with epilepsy, 18% of children with SeLECTS and 3% of all children in Wales had a neurodevelopmental disorder and or school problems. Half of children with SeLECTS were treated with ASM.ConclusionsWe identified a lower than previously reported incidence of SeLECTS, which may be due to under-recording of SeLECTS. There was no change in the incidence of SeLECTS over time, whilst the incidence of childhood epilepsy overall was decreasing. There was no significant association between incidence of SeLECTS and deprivation but the modest sample size needs to be considered. Children with SeLECTS should be screened for neurodevelopmental and or learning comorbidities. Treatment for SeLECTS remains debatable. Journal Article Seizure: European Journal of Epilepsy 122 52 57 Elsevier BV 1059-1311 SeLECTS; Primary Care Records; Epidemiology; Childhood Epilepsy; Routinley Collected Data; Electronic Healthcare Records 1 11 2024 2024-11-01 10.1016/j.seizure.2024.09.008 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee This study was funded by the Waterloo Foundation. 2025-12-05T14:52:12.1829103 2025-10-14T21:54:08.1400129 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science Arron Lacey 0000-0001-7983-8073 1 Carys Jones 2 SEUNG RYOO 3 Jacqueline Stephen 0000-0003-4997-3017 4 Christopher J. Weir 0000-0002-6494-4903 5 Owen Pickrell 0000-0003-4396-5657 6 Richard F. Chin 7 70664__35337__cf9904d32e26421da8bf9e8e730c841a.pdf PIIS1059131124002565.pdf 2025-10-14T21:56:01.6876069 Output 664091 application/pdf Version of Record true © 2024 The Authors. This is an open access article under the CC BY license. true eng http://creativecommons.org/licenses/by/4.0/
title Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records
spellingShingle Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records
Arron Lacey
Carys Jones
SEUNG RYOO
Owen Pickrell
title_short Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records
title_full Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records
title_fullStr Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records
title_full_unstemmed Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records
title_sort Epidemiology of self-limited epilepsy with centrotemporal spikes (SeLECTS): A population study using primary care records
author_id_str_mv b69d245574e754d2637cc9e76379fe11
76dda5f486b0236c893f46dfb9fa2cd0
7909cc4a8fc3bfcb8c8c2e0e0d9933c3
1c3044b5ff7a6552ff5e8c9e3901c807
author_id_fullname_str_mv b69d245574e754d2637cc9e76379fe11_***_Arron Lacey
76dda5f486b0236c893f46dfb9fa2cd0_***_Carys Jones
7909cc4a8fc3bfcb8c8c2e0e0d9933c3_***_SEUNG RYOO
1c3044b5ff7a6552ff5e8c9e3901c807_***_Owen Pickrell
author Arron Lacey
Carys Jones
SEUNG RYOO
Owen Pickrell
author2 Arron Lacey
Carys Jones
SEUNG RYOO
Jacqueline Stephen
Christopher J. Weir
Owen Pickrell
Richard F. Chin
format Journal article
container_title Seizure: European Journal of Epilepsy
container_volume 122
container_start_page 52
publishDate 2024
institution Swansea University
issn 1059-1311
doi_str_mv 10.1016/j.seizure.2024.09.008
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 1
active_str 0
description Background and objectiveInformation on self-limited epilepsy with centrotemporal spikes (SeLECTS) epidemiology is limited. We aimed to determine the incidence of SeLECTS in children, its association with socioeconomic deprivation and the prevalence of neurodevelopmental comorbidities.MethodWe performed a retrospective cohort study (2004–2017) using anonymised, linked, routinely collected, primary care and demographic data for children in Wales. We used primary care diagnosis codes to identify children (aged 0–16 years) with SeLECTS and other epilepsies and to record antiseizure medication (ASM) prescriptions and neurodevelopmental comorbidities. We used a mixed effects Poisson regression model to determine temporal trends of SeLECTS incidence and its association with socioeconomic deprivation.ResultsWe identified 6,732 children with epilepsy, 186 (3%) with SeLECTS. In 2017, epilepsy and SeLECTS prevalence was 0.55% and 0.02% respectively with corresponding crude incidence of 51.2/100,000/year and 1.1/100,000/year. The incidence of epilepsy in children decreased with decreasing deprivation with an adjusted incidence rate ratio (AIRR) of 0.72 (95% CI 0.64–0.82) in the least deprived compared with the most deprived quintile. The corresponding AIRR for children with SeLECTS was 1.35 (95% CI 0.46–1.99). 34% of children with epilepsy, 18% of children with SeLECTS and 3% of all children in Wales had a neurodevelopmental disorder and or school problems. Half of children with SeLECTS were treated with ASM.ConclusionsWe identified a lower than previously reported incidence of SeLECTS, which may be due to under-recording of SeLECTS. There was no change in the incidence of SeLECTS over time, whilst the incidence of childhood epilepsy overall was decreasing. There was no significant association between incidence of SeLECTS and deprivation but the modest sample size needs to be considered. Children with SeLECTS should be screened for neurodevelopmental and or learning comorbidities. Treatment for SeLECTS remains debatable.
published_date 2024-11-01T05:31:23Z
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