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Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae

Qiu E. Yang, Siham Rajab Agouri, Jon Tyrrell Orcid Logo, Timothy Rutland Walsh

Antimicrobial Agents and Chemotherapy, Volume: 62, Issue: 5

Swansea University Author: Jon Tyrrell Orcid Logo

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DOI (Published version): 10.1128/aac.02642-17

Abstract

The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes o...

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Published in: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804 1098-6596
Published: American Society for Microbiology 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa70425
Abstract: The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.
Keywords: heavy metal resistance, blaNDM-1 , blaCTX-M-15 , plasmids, coresistance
College: Faculty of Medicine, Health and Life Sciences
Funders: Q.E.Y. was funded by a CSC scholarship, and T.R.W. was funded by HEFC. T.R.W. and Q.E.Y. were also supported by MRC grant DETER-XDR-China (MR/P007295/1).
Issue: 5

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