Journal article 299 views 76 downloads
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia
Patrícia Amaral,
Rhona Christie 
,
Daisy O. F. Gresham,
Emma Lucas,
Luyao Kevin Xu,
Lena Behrmann ,
Jonathan Bond,
Sofie Degerman ,
Frederik W. van Delft ,
Steven Goossens ,
Melanie Hagleitner,
Chris Halsey ,
Nick Jones ,
Tim Lammens ,
Frank N. van Leeuwen ,
Marc R. Mansour ,
Panagiotis Ntziachristos ,
David O’Connor,
João T. Barata
,
Daisy O. F. Gresham,
Emma Lucas,
Luyao Kevin Xu,
Lena Behrmann ,
Jonathan Bond,
Sofie Degerman ,
Frederik W. van Delft ,
Steven Goossens ,
Melanie Hagleitner,
Chris Halsey ,
Nick Jones ,
Tim Lammens ,
Frank N. van Leeuwen ,
Marc R. Mansour ,
Panagiotis Ntziachristos ,
David O’Connor,
João T. Barata
Leukemia
Swansea University Authors:
Emma Lucas, Nick Jones
-
PDF | Accepted Manuscript
Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention).
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DOI (Published version): 10.1038/s41375-025-02723-2
Abstract
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia
| Published in: | Leukemia |
|---|---|
| ISSN: | 0887-6924 1476-5551 |
| Published: |
Springer Science and Business Media LLC
2025
|
| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa70230 |
| first_indexed |
2025-08-26T12:05:16Z |
|---|---|
| last_indexed |
2025-09-27T06:41:04Z |
| id |
cronfa70230 |
| recordtype |
SURis |
| fullrecord |
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TL is supported by Kinderkankerfonds; JTB is funded also by a Breakthrough Idea Grant from GIMM. PN is funded also by start-up funds from the Department of Biomolecular Medicine, Ghent University, a Flanders interuniversity consortium grant (BOF.IBO.2023.0006.02) and a Cancer Research Institute Ghent (CRIG) partnership grant. FWvD is funded also by JGW Patterson Foundation. MRM is funded through a Great Ormond Street Children’s Charity Professorship. 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2025-09-26T15:02:06.5371124 v2 70230 2025-08-26 Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia 6c3697dd0b6a0b592929045ada8e606e Emma Lucas Emma Lucas true false 0fce0f7ddbdbfeb968f4e2f1e3f86744 0000-0003-4846-5117 Nick Jones Nick Jones true false 2025-08-26 MEDS Journal Article Leukemia 0 Springer Science and Business Media LLC 0887-6924 1476-5551 14 8 2025 2025-08-14 10.1038/s41375-025-02723-2 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University The work related to this review has been funded by the following grants: FKC/ATG4TALL/2023 from the FIGHT KIDS CANCER Program of the European Science Foundation (to FvL, LB, JB, SD, FWvD, SG, CH, DOC and JTB); WWCR 24-0426 from Worldwide Cancer Research, UK (to JTB); 21717 from Programa Gilead GÉNESE, Gilead, Portugal (to JTB); PTDC/MEC-ONC/4606/2021 from Fundação para a Ciência e a Tecnologia, Portugal (to JTB); CCLGA 2020 24 (to CH), CCLGA 2021 05 and CCLGA 2024 08 (to NJ), and CCLGA 2022 20 (to FWvD) from the Children’s Cancer and Leukaemia Group (CCLG) Little Princess Trust; PR2021-0049 from the Swedish Childhood Cancer Foundation (to SD); 24 3490 Pj from the Swedish Cancer Society (to SD); AMP 24-1152 from the Cancer Research Foundation in Northern Sweden (to SD); 20/FFP-P/8844 from Science Foundation Ireland (to JB); 18/SPP/3522 from Science Foundation Ireland together with Children’s Health Ireland (to JB); S002322 and G0A2722N from Research Foundation Flanders (FWO), Flanders, Belgium (to SG); G0F4721N and G0A8B24N from FWO (to PN); F/2024/2666 from the Foundation Against Cancer (to PN); and GN2709 from Action Medical Research (to FWvD); and also by the following awards: DRCPFA-Nov21\100001 from Cancer Research UK Programme Foundation (to CH and RC); A-18-3 from the National Children’s Research Centre/ Children’s Health Foundation Leadership (to JB). TL is supported by Kinderkankerfonds; JTB is funded also by a Breakthrough Idea Grant from GIMM. PN is funded also by start-up funds from the Department of Biomolecular Medicine, Ghent University, a Flanders interuniversity consortium grant (BOF.IBO.2023.0006.02) and a Cancer Research Institute Ghent (CRIG) partnership grant. FWvD is funded also by JGW Patterson Foundation. MRM is funded through a Great Ormond Street Children’s Charity Professorship. DOFG is funded through the Great Ormond Street Children’s Charity. 2025-09-26T15:02:06.5371124 2025-08-26T13:04:17.0825113 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Patrícia Amaral 1 Rhona Christie 0009-0008-7240-4123 2 Daisy O. F. Gresham 3 Emma Lucas 4 Luyao Kevin Xu 5 Lena Behrmann 0009-0008-3255-7504 6 Jonathan Bond 7 Sofie Degerman 0000-0002-2783-0712 8 Frederik W. van Delft 0000-0002-3704-3720 9 Steven Goossens 0000-0002-5693-8570 10 Melanie Hagleitner 11 Chris Halsey 0000-0001-5449-5246 12 Nick Jones 0000-0003-4846-5117 13 Tim Lammens 0000-0001-8733-4027 14 Frank N. van Leeuwen 0000-0003-1107-6513 15 Marc R. Mansour 0000-0001-6835-3791 16 Panagiotis Ntziachristos 0000-0001-6374-8954 17 David O’Connor 18 João T. Barata 0000-0002-4826-8976 19 70230__35187__119c0a6b58e548a6860d522e9a56516d.pdf 70230.AAM.pdf 2025-09-26T14:46:49.1708354 Output 10020122 application/pdf Accepted Manuscript true Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention). true eng https://creativecommons.org/licenses/by/4.0/deed.en |
| title |
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia |
| spellingShingle |
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia Emma Lucas Nick Jones |
| title_short |
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia |
| title_full |
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia |
| title_fullStr |
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia |
| title_full_unstemmed |
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia |
| title_sort |
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia |
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6c3697dd0b6a0b592929045ada8e606e 0fce0f7ddbdbfeb968f4e2f1e3f86744 |
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6c3697dd0b6a0b592929045ada8e606e_***_Emma Lucas 0fce0f7ddbdbfeb968f4e2f1e3f86744_***_Nick Jones |
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Emma Lucas Nick Jones |
| author2 |
Patrícia Amaral Rhona Christie Daisy O. F. Gresham Emma Lucas Luyao Kevin Xu Lena Behrmann Jonathan Bond Sofie Degerman Frederik W. van Delft Steven Goossens Melanie Hagleitner Chris Halsey Nick Jones Tim Lammens Frank N. van Leeuwen Marc R. Mansour Panagiotis Ntziachristos David O’Connor João T. Barata |
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Leukemia |
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2025 |
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10.1038/s41375-025-02723-2 |
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Springer Science and Business Media LLC |
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Faculty of Medicine, Health and Life Sciences |
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