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Adrenal cortex senescence: an ageing-related pathology?

Emma Short Orcid Logo, Ramzi Ajjan, Thomas M. Barber, Ian Benson, Victoria Higginbotham, Robert Huckstepp, Venkat Kanamarlapudi Orcid Logo, Natasha Mumwiro, Stuart R. G. Calimport, Barry Bentley

Journal of Endocrinological Investigation, Volume: 48, Issue: 7, Pages: 1515 - 1524

Swansea University Authors: Victoria Higginbotham, Venkat Kanamarlapudi Orcid Logo

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DOI (Published version): 10.1007/s40618-025-02566-9

Abstract

The adrenal glands are a pair of endocrine organs that produce and secrete mineralocorticoids, glucocorticoids, sex hormones, adrenaline, and noradrenaline. They have a vital role in a range of physiological processes including regulating electrolyte balance, blood pressure and metabolism, immunomod...

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Published in: Journal of Endocrinological Investigation
ISSN: 1720-8386
Published: Springer Nature 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa70108
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spelling 2025-08-04T14:15:55.1315748 v2 70108 2025-08-04 Adrenal cortex senescence: an ageing-related pathology? 29dd07a8a73cf872888e406e01ee766f Victoria Higginbotham Victoria Higginbotham true false 63741801137148abfa4c00cd547dcdfa 0000-0002-8739-1483 Venkat Kanamarlapudi Venkat Kanamarlapudi true false 2025-08-04 MEDS The adrenal glands are a pair of endocrine organs that produce and secrete mineralocorticoids, glucocorticoids, sex hormones, adrenaline, and noradrenaline. They have a vital role in a range of physiological processes including regulating electrolyte balance, blood pressure and metabolism, immunomodulation, sexual development and the stress response. Adrenal cortex senescence describes the ageing-related decline in the normal functioning of the adrenal cortex, characterised by an alteration in the output of adrenal cortical hormones, in particular reduced secretion of dehydroepiandrosterone (DHEA) and sulfated dehydroepiandrosterone (DHEAS). Such endocrine aberrations may be implicated in adverse clinical outcomes including mood disturbances, impairment in cognitive functioning, metabolic dysfunction and osteopenia. This paper shall address whether adrenal cortex senescence should be recognised as an ageing-related pathology, which has recently been defined as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline, and is evidenced by studies in humans. Journal Article Journal of Endocrinological Investigation 48 7 1515 1524 Springer Nature 1720-8386 Adrenal cortex senescence; Adrenal cortex ageing; Senescence; Healthy longevity 1 7 2025 2025-07-01 10.1007/s40618-025-02566-9 Opinion COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee The project is funded by an Impetus grant from the Norn group. RH is funded by BBSRC (Grant number: BB/X008290/1). 2025-08-04T14:15:55.1315748 2025-08-04T14:03:36.4007135 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Emma Short 0000-0001-5050-589X 1 Ramzi Ajjan 2 Thomas M. Barber 3 Ian Benson 4 Victoria Higginbotham 5 Robert Huckstepp 6 Venkat Kanamarlapudi 0000-0002-8739-1483 7 Natasha Mumwiro 8 Stuart R. G. Calimport 9 Barry Bentley 10 70108__34909__15ad021c166f41b9ba77a9c2067a6b3b.pdf 40618_2025_Article_2566.pdf 2025-08-04T14:03:36.4003453 Output 1421831 application/pdf Version of Record true © The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). true eng http://creativecommons.org/licenses/by/4.0/
title Adrenal cortex senescence: an ageing-related pathology?
spellingShingle Adrenal cortex senescence: an ageing-related pathology?
Victoria Higginbotham
Venkat Kanamarlapudi
title_short Adrenal cortex senescence: an ageing-related pathology?
title_full Adrenal cortex senescence: an ageing-related pathology?
title_fullStr Adrenal cortex senescence: an ageing-related pathology?
title_full_unstemmed Adrenal cortex senescence: an ageing-related pathology?
title_sort Adrenal cortex senescence: an ageing-related pathology?
author_id_str_mv 29dd07a8a73cf872888e406e01ee766f
63741801137148abfa4c00cd547dcdfa
author_id_fullname_str_mv 29dd07a8a73cf872888e406e01ee766f_***_Victoria Higginbotham
63741801137148abfa4c00cd547dcdfa_***_Venkat Kanamarlapudi
author Victoria Higginbotham
Venkat Kanamarlapudi
author2 Emma Short
Ramzi Ajjan
Thomas M. Barber
Ian Benson
Victoria Higginbotham
Robert Huckstepp
Venkat Kanamarlapudi
Natasha Mumwiro
Stuart R. G. Calimport
Barry Bentley
format Journal article
container_title Journal of Endocrinological Investigation
container_volume 48
container_issue 7
container_start_page 1515
publishDate 2025
institution Swansea University
issn 1720-8386
doi_str_mv 10.1007/s40618-025-02566-9
publisher Springer Nature
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
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description The adrenal glands are a pair of endocrine organs that produce and secrete mineralocorticoids, glucocorticoids, sex hormones, adrenaline, and noradrenaline. They have a vital role in a range of physiological processes including regulating electrolyte balance, blood pressure and metabolism, immunomodulation, sexual development and the stress response. Adrenal cortex senescence describes the ageing-related decline in the normal functioning of the adrenal cortex, characterised by an alteration in the output of adrenal cortical hormones, in particular reduced secretion of dehydroepiandrosterone (DHEA) and sulfated dehydroepiandrosterone (DHEAS). Such endocrine aberrations may be implicated in adverse clinical outcomes including mood disturbances, impairment in cognitive functioning, metabolic dysfunction and osteopenia. This paper shall address whether adrenal cortex senescence should be recognised as an ageing-related pathology, which has recently been defined as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline, and is evidenced by studies in humans.
published_date 2025-07-01T05:29:59Z
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