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Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men

Che-Wei Hsu, Chieh-Sheng Tseng, Richard Metcalfe Orcid Logo, Yung-Chih Chen Orcid Logo

European Journal of Applied Physiology

Swansea University Author: Richard Metcalfe Orcid Logo

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DOI (Published version): 10.1007/s00421-025-05909-9

Abstract

Background: High-intensity interval exercise ameliorates the impairment of postprandial metabolic health (glucose control) that is observed after a night of inadequate sleep. It is unknown whether moderate-intensity walking can elicit similar effects. Methods: Eleven healthy active males (age: 26±2...

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Published in: European Journal of Applied Physiology
ISSN: 1439-6319 1439-6327
Published: Springer Science and Business Media LLC 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa69903
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Methods: Eleven healthy active males (age: 26&#xB1;2 yr; BMI: 22.8&#xB1;2.6 kg/m2) took part in a randomised and repeated measures cross-over study with: 1) normal sleep (NS; 8 h sleep opportunity); 2) sleep restriction (SR; 3 h sleep opportunity); and 3) sleep restriction + exercise (SRE; 3 h sleep opportunity followed by 30 min brisk walking at 50%V&#x307;O2max). This was followed by a 2-h 75g oral glucose tolerance test (OGTT), with plasma samples collected at baseline, immediately post-exercise (or sedentary), and at regular intervals during OGTT. Results: Total glucose area under the curve (tAUC) was lower in NS trial (924 [95%CI = 865, 982] mmol/L) compared to both SR (1012 [95%CI = 945, 1080] mmol/L, p=0.018) and SRE trials (1006 [933, 1080] mmol/L, p=0.002) and there was no difference between SR and SRE (p=1.00). Insulin tAUC did not differ between trials (p=0.472). There were no differences in fasting cortisol, c-reative protein, and non-esterified fatty acids, and fasting and postprandial triacylglycerols, cholesterol, aspartate aminotransferase and alanine aminotransferase concentrations between trials (all, p&gt;0.05). 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This project was financially supported by the National Science and Technology Council of Taiwan (110&#x2013;2410-H-003&#x2013;146-MY2) and was also partially funded by the National Taiwan Normal University (NTNU) within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan to Y-CC.</funders><projectreference/><lastEdited>2025-09-04T13:05:47.7826723</lastEdited><Created>2025-07-07T10:07:29.2779883</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Sport and Exercise Sciences</level></path><authors><author><firstname>Che-Wei</firstname><surname>Hsu</surname><order>1</order></author><author><firstname>Chieh-Sheng</firstname><surname>Tseng</surname><order>2</order></author><author><firstname>Richard</firstname><surname>Metcalfe</surname><orcid>0000-0003-0980-2977</orcid><order>3</order></author><author><firstname>Yung-Chih</firstname><surname>Chen</surname><orcid>0000-0002-0133-717x</orcid><order>4</order></author></authors><documents><document><filename>69903__34992__a563497a82b9468ca0b30d328424f14f.pdf</filename><originalFilename>Hsu et al EJAP 2025.pdf</originalFilename><uploaded>2025-08-26T16:51:29.6583684</uploaded><type>Output</type><contentLength>1549938</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; The Author(s) 2025. 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spelling 2025-09-04T13:05:47.7826723 v2 69903 2025-07-07 Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men 9bb783273dd9d54a2f3f66f75c43abdf 0000-0003-0980-2977 Richard Metcalfe Richard Metcalfe true false 2025-07-07 EAAS Background: High-intensity interval exercise ameliorates the impairment of postprandial metabolic health (glucose control) that is observed after a night of inadequate sleep. It is unknown whether moderate-intensity walking can elicit similar effects. Methods: Eleven healthy active males (age: 26±2 yr; BMI: 22.8±2.6 kg/m2) took part in a randomised and repeated measures cross-over study with: 1) normal sleep (NS; 8 h sleep opportunity); 2) sleep restriction (SR; 3 h sleep opportunity); and 3) sleep restriction + exercise (SRE; 3 h sleep opportunity followed by 30 min brisk walking at 50%V̇O2max). This was followed by a 2-h 75g oral glucose tolerance test (OGTT), with plasma samples collected at baseline, immediately post-exercise (or sedentary), and at regular intervals during OGTT. Results: Total glucose area under the curve (tAUC) was lower in NS trial (924 [95%CI = 865, 982] mmol/L) compared to both SR (1012 [95%CI = 945, 1080] mmol/L, p=0.018) and SRE trials (1006 [933, 1080] mmol/L, p=0.002) and there was no difference between SR and SRE (p=1.00). Insulin tAUC did not differ between trials (p=0.472). There were no differences in fasting cortisol, c-reative protein, and non-esterified fatty acids, and fasting and postprandial triacylglycerols, cholesterol, aspartate aminotransferase and alanine aminotransferase concentrations between trials (all, p>0.05). Conclusion: In healthy physically active young males, a single night of partial sleep restriction results in a decrease in glucose tolerance during a 2-h OGTT performed the following morning and this impaired response is not rescued by 30 min of brisk walking immediately prior to the OGTT. Journal Article European Journal of Applied Physiology 0 Springer Science and Business Media LLC 1439-6319 1439-6327 Partial sleep deprivation; Brisk walking; Glycemic control; Metabolic health 21 8 2025 2025-08-21 10.1007/s00421-025-05909-9 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee Open access funding provided by National Taiwan Normal University. This project was financially supported by the National Science and Technology Council of Taiwan (110–2410-H-003–146-MY2) and was also partially funded by the National Taiwan Normal University (NTNU) within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan to Y-CC. 2025-09-04T13:05:47.7826723 2025-07-07T10:07:29.2779883 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Che-Wei Hsu 1 Chieh-Sheng Tseng 2 Richard Metcalfe 0000-0003-0980-2977 3 Yung-Chih Chen 0000-0002-0133-717x 4 69903__34992__a563497a82b9468ca0b30d328424f14f.pdf Hsu et al EJAP 2025.pdf 2025-08-26T16:51:29.6583684 Output 1549938 application/pdf Version of Record true © The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men
spellingShingle Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men
Richard Metcalfe
title_short Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men
title_full Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men
title_fullStr Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men
title_full_unstemmed Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men
title_sort Acute impairments in glucose tolerance following one night of partial sleep restriction are not rescued by moderate-intensity walking in young men
author_id_str_mv 9bb783273dd9d54a2f3f66f75c43abdf
author_id_fullname_str_mv 9bb783273dd9d54a2f3f66f75c43abdf_***_Richard Metcalfe
author Richard Metcalfe
author2 Che-Wei Hsu
Chieh-Sheng Tseng
Richard Metcalfe
Yung-Chih Chen
format Journal article
container_title European Journal of Applied Physiology
container_volume 0
publishDate 2025
institution Swansea University
issn 1439-6319
1439-6327
doi_str_mv 10.1007/s00421-025-05909-9
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
document_store_str 1
active_str 0
description Background: High-intensity interval exercise ameliorates the impairment of postprandial metabolic health (glucose control) that is observed after a night of inadequate sleep. It is unknown whether moderate-intensity walking can elicit similar effects. Methods: Eleven healthy active males (age: 26±2 yr; BMI: 22.8±2.6 kg/m2) took part in a randomised and repeated measures cross-over study with: 1) normal sleep (NS; 8 h sleep opportunity); 2) sleep restriction (SR; 3 h sleep opportunity); and 3) sleep restriction + exercise (SRE; 3 h sleep opportunity followed by 30 min brisk walking at 50%V̇O2max). This was followed by a 2-h 75g oral glucose tolerance test (OGTT), with plasma samples collected at baseline, immediately post-exercise (or sedentary), and at regular intervals during OGTT. Results: Total glucose area under the curve (tAUC) was lower in NS trial (924 [95%CI = 865, 982] mmol/L) compared to both SR (1012 [95%CI = 945, 1080] mmol/L, p=0.018) and SRE trials (1006 [933, 1080] mmol/L, p=0.002) and there was no difference between SR and SRE (p=1.00). Insulin tAUC did not differ between trials (p=0.472). There were no differences in fasting cortisol, c-reative protein, and non-esterified fatty acids, and fasting and postprandial triacylglycerols, cholesterol, aspartate aminotransferase and alanine aminotransferase concentrations between trials (all, p>0.05). Conclusion: In healthy physically active young males, a single night of partial sleep restriction results in a decrease in glucose tolerance during a 2-h OGTT performed the following morning and this impaired response is not rescued by 30 min of brisk walking immediately prior to the OGTT.
published_date 2025-08-21T14:17:09Z
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