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The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume

Jie Zhang Orcid Logo, Johnny LM Blaschek, Matthew Hutchinson, Daniel Kinghorn, Richard Metcalfe Orcid Logo, Elliott C.R. Hall Orcid Logo, Kerrie L. Bartie, Niels B.J. Vollaard

Journal of Applied Sports Sciences, Volume: 9, Issue: 1, Pages: 12 - 23

Swansea University Author: Richard Metcalfe Orcid Logo

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DOI (Published version): 10.37393/jass.2025.09.01.2

Abstract

The magnitude of the benefi cial increase in plasma interleukin-6 (IL-6) with exercise is greater with continuous exercise of higher intensity and longer duration. However, it is unknown whether a greater volume of supramaximal interval exercise also enhances the IL-6 response. Therefore, the aim of...

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Published in: Journal of Applied Sports Sciences
ISSN: 2534-9597 2535-0145
Published: National Sports Academy - Vassil Levski 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa69842
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Therefore, the aim of this study was to compare the eff ects of two sprint interval training (SIT) protocols involving different volumes of sprint exercise on plasma IL-6 levels. Nine healthy young men (age: 24&#xB1;4 y, BMI: 23.3&#xB1;3.1 kg&#xB7;m-2, V&#x307; O2max: 42&#xB1;6 mL&#xB7;kg-1&#xB7;min-1) completed three experimental trials in randomised order, including &#x2018;classic&#x2019; SIT (4x30-s &#x2018;all-out&#x2019; cycle sprints within a 22-min session), reduced-exertion high-intensity interval training (REHIT; 2x20-s &#x2018;all-out&#x2019; cycle sprints within a 10-min session), and a control condition (seated rest). Blood samples were collected before exercise and at 0-, 30-, and 90-min post-exercise, and analyzed for lactate and IL-6. Blood lactate levels peaked directly post-SIT (1.5&#xB1;0.2 mM to 11.9&#xB1;2.5 mM; p&lt;.001) and REHIT (1.7&#xB1;0.4 to 9.1&#xB1;3.1 mM; p&lt;.001). Plasma IL-6 levels peaked 30-min post-exercise (0.84&#xB1;0.12 to 1.31&#xB1;0.17 pg&#xB7;mL-1 for SIT, p=.003; 0.75&#xB1;0.09 to 1.18&#xB1;0.36 pg&#xB7;mL-1 for REHIT, p=.028). Compared to the con-trol trial, IL-6 iAUC was signifi cantly higher for both SIT (p=.002) and REHIT (p=.013), with no signifi cant diff erence between SIT and REHIT. In conclusion, we demonstrate that the increase in plasma IL-6 levels is similar for the two SIT protocols involving a 3-fold diff erence in sprint exercise volume (120 s vs. 40 s). 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spelling 2025-07-25T11:45:33.7181618 v2 69842 2025-06-30 The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume 9bb783273dd9d54a2f3f66f75c43abdf 0000-0003-0980-2977 Richard Metcalfe Richard Metcalfe true false 2025-06-30 EAAS The magnitude of the benefi cial increase in plasma interleukin-6 (IL-6) with exercise is greater with continuous exercise of higher intensity and longer duration. However, it is unknown whether a greater volume of supramaximal interval exercise also enhances the IL-6 response. Therefore, the aim of this study was to compare the eff ects of two sprint interval training (SIT) protocols involving different volumes of sprint exercise on plasma IL-6 levels. Nine healthy young men (age: 24±4 y, BMI: 23.3±3.1 kg·m-2, V̇ O2max: 42±6 mL·kg-1·min-1) completed three experimental trials in randomised order, including ‘classic’ SIT (4x30-s ‘all-out’ cycle sprints within a 22-min session), reduced-exertion high-intensity interval training (REHIT; 2x20-s ‘all-out’ cycle sprints within a 10-min session), and a control condition (seated rest). Blood samples were collected before exercise and at 0-, 30-, and 90-min post-exercise, and analyzed for lactate and IL-6. Blood lactate levels peaked directly post-SIT (1.5±0.2 mM to 11.9±2.5 mM; p<.001) and REHIT (1.7±0.4 to 9.1±3.1 mM; p<.001). Plasma IL-6 levels peaked 30-min post-exercise (0.84±0.12 to 1.31±0.17 pg·mL-1 for SIT, p=.003; 0.75±0.09 to 1.18±0.36 pg·mL-1 for REHIT, p=.028). Compared to the con-trol trial, IL-6 iAUC was signifi cantly higher for both SIT (p=.002) and REHIT (p=.013), with no signifi cant diff erence between SIT and REHIT. In conclusion, we demonstrate that the increase in plasma IL-6 levels is similar for the two SIT protocols involving a 3-fold diff erence in sprint exercise volume (120 s vs. 40 s). Our data provide support for a possible role of glycogenolysis in the IL-6 response to SIT. Journal Article Journal of Applied Sports Sciences 9 1 12 23 National Sports Academy - Vassil Levski 2534-9597 2535-0145 interleukin-6, lactate, Reduced-exertion high-intensity interval training, REHIT, SIT 14 7 2025 2025-07-14 10.37393/jass.2025.09.01.2 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee The study was funded by a grant from Integrated Health Partners Limited. JZ was funded by the China Scholarship Council (202206635004). 2025-07-25T11:45:33.7181618 2025-06-30T10:24:34.7416546 Faculty of Science and Engineering School of Engineering and Applied Sciences - Sport and Exercise Sciences Jie Zhang 0000-0002-3079-0977 1 Johnny LM Blaschek 2 Matthew Hutchinson 3 Daniel Kinghorn 4 Richard Metcalfe 0000-0003-0980-2977 5 Elliott C.R. Hall 0000-0003-0540-0735 6 Kerrie L. Bartie 7 Niels B.J. Vollaard 8 69842__34843__4af63ee0d7b54b83a2e313174deb039b.pdf 69842.VoR.pdf 2025-07-25T11:42:21.6574712 Output 1356508 application/pdf Version of Record true © Jie Zhang, Johnny LM Blaschek, Matthew Hutchinson, Daniel Kinghorn, Richard S. Metcalfe, Elliott C.R. Hall, Kerrie L. Bartie, Niels B.J. Vollaard. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY-NC-SA 4.0). true eng https://creativecommons.org/licenses/by-nc-sa/4.0/
title The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume
spellingShingle The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume
Richard Metcalfe
title_short The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume
title_full The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume
title_fullStr The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume
title_full_unstemmed The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume
title_sort The increase in plasma IL-6 following sprint interval training does not depend on total sprint volume
author_id_str_mv 9bb783273dd9d54a2f3f66f75c43abdf
author_id_fullname_str_mv 9bb783273dd9d54a2f3f66f75c43abdf_***_Richard Metcalfe
author Richard Metcalfe
author2 Jie Zhang
Johnny LM Blaschek
Matthew Hutchinson
Daniel Kinghorn
Richard Metcalfe
Elliott C.R. Hall
Kerrie L. Bartie
Niels B.J. Vollaard
format Journal article
container_title Journal of Applied Sports Sciences
container_volume 9
container_issue 1
container_start_page 12
publishDate 2025
institution Swansea University
issn 2534-9597
2535-0145
doi_str_mv 10.37393/jass.2025.09.01.2
publisher National Sports Academy - Vassil Levski
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Sport and Exercise Sciences
document_store_str 1
active_str 0
description The magnitude of the benefi cial increase in plasma interleukin-6 (IL-6) with exercise is greater with continuous exercise of higher intensity and longer duration. However, it is unknown whether a greater volume of supramaximal interval exercise also enhances the IL-6 response. Therefore, the aim of this study was to compare the eff ects of two sprint interval training (SIT) protocols involving different volumes of sprint exercise on plasma IL-6 levels. Nine healthy young men (age: 24±4 y, BMI: 23.3±3.1 kg·m-2, V̇ O2max: 42±6 mL·kg-1·min-1) completed three experimental trials in randomised order, including ‘classic’ SIT (4x30-s ‘all-out’ cycle sprints within a 22-min session), reduced-exertion high-intensity interval training (REHIT; 2x20-s ‘all-out’ cycle sprints within a 10-min session), and a control condition (seated rest). Blood samples were collected before exercise and at 0-, 30-, and 90-min post-exercise, and analyzed for lactate and IL-6. Blood lactate levels peaked directly post-SIT (1.5±0.2 mM to 11.9±2.5 mM; p<.001) and REHIT (1.7±0.4 to 9.1±3.1 mM; p<.001). Plasma IL-6 levels peaked 30-min post-exercise (0.84±0.12 to 1.31±0.17 pg·mL-1 for SIT, p=.003; 0.75±0.09 to 1.18±0.36 pg·mL-1 for REHIT, p=.028). Compared to the con-trol trial, IL-6 iAUC was signifi cantly higher for both SIT (p=.002) and REHIT (p=.013), with no signifi cant diff erence between SIT and REHIT. In conclusion, we demonstrate that the increase in plasma IL-6 levels is similar for the two SIT protocols involving a 3-fold diff erence in sprint exercise volume (120 s vs. 40 s). Our data provide support for a possible role of glycogenolysis in the IL-6 response to SIT.
published_date 2025-07-14T05:29:14Z
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