Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Zhong, Jie; Mareque-Rivas, Juan; Lan, Xinmiao; Su, Yu‐Xiong

doi:10.1002/agt2.70081

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Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Jie Zhong

, Juan Mareque-Rivas

, Xinmiao Lan

, Yu‐Xiong Su

Aggregate, Start page: e70081

Swansea University Author: Juan Mareque-Rivas

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DOI (Published version): 10.1002/agt2.70081

Abstract

Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted the potential of triterpenoids to form organi...

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ISSN:	2692-4560 2692-4560
Published:	Wiley 2025
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URI:	https://cronfa.swan.ac.uk/Record/cronfa69830

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spelling	2025-08-01T14:34:19.2606265 v2 69830 2025-06-27 Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives 14faad807724ffe1fb168c3fc225be0e 0000-0002-7405-3338 Juan Mareque-Rivas Juan Mareque-Rivas true false 2025-06-27 EAAS Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted the potential of triterpenoids to form organized assemblies through noncovalent interactions, affording versatile functional properties. By leveraging their unique structural characteristics and biological activities, innovative strategies can be developed to enhance the efficacy and safety of biomedical therapies. This review describes the recent advances in triterpenoids serving as (i) functional groups for aggregation‐induced emission, (ii) building blocks for self‐transportation and drug delivery, (iii) potential gelators for rational hydrogel design, and (iv) cholesterol alternatives for optimizing lipid‐based nanoparticles. The biomedical perspectives of triterpenoid‐based supramolecular assemblies and potential bottlenecks in clinical translation are also discussed, with the hope of offering insights into future research and biomedical applications. Journal Article Aggregate 0 e70081 Wiley 2692-4560 2692-4560 hydrogels, nanotheranostics, natural products, supramolecular assembly, triterpenoids 26 6 2025 2025-06-26 10.1002/agt2.70081 Review COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University Another institution paid the OA fee This study was supported by the National Natural Science Foundation of China (NSFC) project (32301133), the University of Hong Kong Seed Fund for Basic Research (104006533), and the R&D Program of Beijing Municipal Education Commission (KM202310025022). 2025-08-01T14:34:19.2606265 2025-06-27T10:54:19.5202057 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Jie Zhong 0000-0003-0147-9781 1 Juan Mareque-Rivas 0000-0002-7405-3338 2 Xinmiao Lan 0000-0002-7503-6310 3 Yu‐Xiong Su 0000-0001-7143-3370 4 69830__34604__22f046fecc554859a4f54ab6fa539f19.pdf agt2.70081.pdf 2025-06-27T10:54:19.4928511 Output 6639699 application/pdf Version of Record true © 2025 The Author(s). Aggregate published by SCUT, AIEI, and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution License (CC BY). true eng http://creativecommons.org/licenses/by/4.0/
title	Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
spellingShingle	Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives Juan Mareque-Rivas
title_short	Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
title_full	Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
title_fullStr	Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
title_full_unstemmed	Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
title_sort	Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
author_id_str_mv	14faad807724ffe1fb168c3fc225be0e
author_id_fullname_str_mv	14faad807724ffe1fb168c3fc225be0e_***_Juan Mareque-Rivas
author	Juan Mareque-Rivas
author2	Jie Zhong Juan Mareque-Rivas Xinmiao Lan Yu‐Xiong Su
format	Journal article
container_title	Aggregate
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container_start_page	e70081
publishDate	2025
institution	Swansea University
issn	2692-4560 2692-4560
doi_str_mv	10.1002/agt2.70081
publisher	Wiley
college_str	Faculty of Science and Engineering
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hierarchy_top_title	Faculty of Science and Engineering
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department_str	School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
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description	Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted the potential of triterpenoids to form organized assemblies through noncovalent interactions, affording versatile functional properties. By leveraging their unique structural characteristics and biological activities, innovative strategies can be developed to enhance the efficacy and safety of biomedical therapies. This review describes the recent advances in triterpenoids serving as (i) functional groups for aggregation‐induced emission, (ii) building blocks for self‐transportation and drug delivery, (iii) potential gelators for rational hydrogel design, and (iv) cholesterol alternatives for optimizing lipid‐based nanoparticles. The biomedical perspectives of triterpenoid‐based supramolecular assemblies and potential bottlenecks in clinical translation are also discussed, with the hope of offering insights into future research and biomedical applications.
published_date	2025-06-26T05:27:59Z
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Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

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