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Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease

J.C. Smith, C.H. Seage, E. Lane, Delyth James Orcid Logo

Exploratory Research in Clinical and Social Pharmacy, Volume: 11, Start page: 100309

Swansea University Author: Delyth James Orcid Logo

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DOI (Published version): 10.1016/j.rcsop.2023.100309

Abstract

BackgroundPatient medication adherence in Parkinson's Disease (PD) is often suboptimal. This may lead to poor symptom management, greater disease burden, decreased quality of life and increased healthcare costs. Use of psychological theory such as the Theoretical Domains Framework (TDF) has eff...

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Published in: Exploratory Research in Clinical and Social Pharmacy
ISSN: 2667-2766
Published: Elsevier BV 2023
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URI: https://cronfa.swan.ac.uk/Record/cronfa69689
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spelling 2025-07-10T13:06:38.7184182 v2 69689 2025-06-11 Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease dc24cdd4d09d96fa49a0f213d1060cf9 0000-0001-7434-7064 Delyth James Delyth James true false 2025-06-11 MEDS BackgroundPatient medication adherence in Parkinson's Disease (PD) is often suboptimal. This may lead to poor symptom management, greater disease burden, decreased quality of life and increased healthcare costs. Use of psychological theory such as the Theoretical Domains Framework (TDF) has effectively captured barriers and facilitators to medication adherence in other long-term conditions. Applying this framework to medication adherence in PD could provide a better understanding of the challenges to inform the development of effective interventions.ObjectivesThe aim of the study was to apply the TDF to determine the barriers and facilitators to medication adherence in people with PD.MethodologyThis qualitative study employed online interviews to explore medication adherence in a small group of people with PD recruited via Parkinson's UK and social media. A semi-structured interview schedule was designed informed by the 14 TDF domains. All interviews were audio-recorded, transcribed verbatim and mapped to the TDF using Framework Analysis.ResultsTwelve participants diagnosed with PD were interviewed, 11 of whom were currently taking prescribed medication plus another self-medicating with Vitamin B1. All TDF domains were evident in the data. Predominant facilitators were Domains 1 - Knowledge, 6 - Social Influence, and 12 - Beliefs about Consequences and barriers were 7 - Reinforcement, 10 - Memory, Attention and Decision Processes, and 11 - Environmental Context and Resources. Other themes were not related to medication adherence.ConclusionIn this small group, all data relating to the barriers and facilitators for medication adherence in PD were successfully mapped onto the TDF. This indicates the utility of the framework for determining and structuring the factors to consider when providing medication support for this patient population in an accessible and coherent way. Further quantitative studies are needed to determine the extent to which these factors can be generalised to other PD patients. Journal Article Exploratory Research in Clinical and Social Pharmacy 11 100309 Elsevier BV 2667-2766 Parkinson&apos;s disease; Medication adherence; Theoretical domains framework; Barriers; Facilitators 1 9 2023 2023-09-01 10.1016/j.rcsop.2023.100309 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee 2025-07-10T13:06:38.7184182 2025-06-11T14:37:28.2225001 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy J.C. Smith 1 C.H. Seage 2 E. Lane 3 Delyth James 0000-0001-7434-7064 4 69689__34730__5409dc3ba6904a5a817ea4af828722d9.pdf 69689.VoR.pdf 2025-07-10T13:04:35.0458476 Output 435002 application/pdf Version of Record true © 2023 The Authors. This is an open access article under the CC BY-NC-ND license. true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease
spellingShingle Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease
Delyth James
title_short Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease
title_full Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease
title_fullStr Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease
title_full_unstemmed Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease
title_sort Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease
author_id_str_mv dc24cdd4d09d96fa49a0f213d1060cf9
author_id_fullname_str_mv dc24cdd4d09d96fa49a0f213d1060cf9_***_Delyth James
author Delyth James
author2 J.C. Smith
C.H. Seage
E. Lane
Delyth James
format Journal article
container_title Exploratory Research in Clinical and Social Pharmacy
container_volume 11
container_start_page 100309
publishDate 2023
institution Swansea University
issn 2667-2766
doi_str_mv 10.1016/j.rcsop.2023.100309
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
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description BackgroundPatient medication adherence in Parkinson's Disease (PD) is often suboptimal. This may lead to poor symptom management, greater disease burden, decreased quality of life and increased healthcare costs. Use of psychological theory such as the Theoretical Domains Framework (TDF) has effectively captured barriers and facilitators to medication adherence in other long-term conditions. Applying this framework to medication adherence in PD could provide a better understanding of the challenges to inform the development of effective interventions.ObjectivesThe aim of the study was to apply the TDF to determine the barriers and facilitators to medication adherence in people with PD.MethodologyThis qualitative study employed online interviews to explore medication adherence in a small group of people with PD recruited via Parkinson's UK and social media. A semi-structured interview schedule was designed informed by the 14 TDF domains. All interviews were audio-recorded, transcribed verbatim and mapped to the TDF using Framework Analysis.ResultsTwelve participants diagnosed with PD were interviewed, 11 of whom were currently taking prescribed medication plus another self-medicating with Vitamin B1. All TDF domains were evident in the data. Predominant facilitators were Domains 1 - Knowledge, 6 - Social Influence, and 12 - Beliefs about Consequences and barriers were 7 - Reinforcement, 10 - Memory, Attention and Decision Processes, and 11 - Environmental Context and Resources. Other themes were not related to medication adherence.ConclusionIn this small group, all data relating to the barriers and facilitators for medication adherence in PD were successfully mapped onto the TDF. This indicates the utility of the framework for determining and structuring the factors to consider when providing medication support for this patient population in an accessible and coherent way. Further quantitative studies are needed to determine the extent to which these factors can be generalised to other PD patients.
published_date 2023-09-01T05:28:52Z
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