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Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care

Ali Haider Mohammed, Bassam Abdul Rasool Hassan Orcid Logo, Lim Jie Sern, Lim Jing Xuan, Leong Jia Yun, Lim Jing En, Dinesh Sangarran Ramachandram, Angelina Lim, Juman Abdulelah Dujaili, Ali Blebil Orcid Logo

PLOS One, Volume: 20, Issue: 5, Start page: e0321551

Swansea University Author: Ali Blebil Orcid Logo

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DOI (Published version): 10.1371/journal.pone.0321551

Abstract

BackgroundCancer patients who receive immunosuppressive therapy are vulnerable to infections due to their compromised immune systems. Therefore, research in promoting the prudent use of antibiotics in this population is essential to optimise patient outcomes and reduce resistance development. The pu...

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ISSN: 1932-6203 1932-6203
Published: Public Library of Science (PLoS) 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa69616
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The purpose of this study is to develop and validate the Knowledge and Practice of Antimicrobial Stewardship in the Oncology Care Questionnaire (KP-AMS-OC-Q).MethodThis research is performed in 2 phases. Phase I includes the questionnaire development, item generation, content validity and pilot testing. Phase II encompasses the dissemination of questionnaires to hospital pharmacists and the psychometric evaluation of the validation and reliability of KP-AMS-OC-Q. Specifically, IRT is used to evaluate the knowledge domains, EFA for the practice domains, and Cronbach alpha to measure reliability.ResultThe finalised version of the questionnaire consisted of 112 items, including 7 social demographics, 49 knowledge, and 56 practice items. IRT conducted has revealed an acceptable difficulty parameter (-3 to +3) in the knowledge domain. Furthermore, EFA has shown a strong internal association between the items and factors, with each item reaching the minimum acceptable factor loading value (&gt;0.3). Besides this, the internal consistency of this questionnaire is favourable, indicated by the Cronbach alpha coefficient of 0.899.ConclusionThe results of this study have validated that KP-AMS-OC-Q possesses exceptional psychometric qualities, making it appropriate to measure pharmacists&#x2019; knowledge and practice towards antimicrobial stewardship (AMS) in oncology care.</abstract><type>Journal Article</type><journal>PLOS One</journal><volume>20</volume><journalNumber>5</journalNumber><paginationStart>e0321551</paginationStart><paginationEnd/><publisher>Public Library of Science (PLoS)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1932-6203</issnPrint><issnElectronic>1932-6203</issnElectronic><keywords/><publishedDay>23</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2025</publishedYear><publishedDate>2025-05-23</publishedDate><doi>10.1371/journal.pone.0321551</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>The author(s) received no specific funding for this work.</funders><projectreference/><lastEdited>2025-06-02T12:52:46.2203846</lastEdited><Created>2025-06-02T12:43:34.2819382</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Pharmacy</level></path><authors><author><firstname>Ali Haider</firstname><surname>Mohammed</surname><order>1</order></author><author><firstname>Bassam Abdul Rasool</firstname><surname>Hassan</surname><orcid>0000-0001-5822-0442</orcid><order>2</order></author><author><firstname>Lim Jie</firstname><surname>Sern</surname><order>3</order></author><author><firstname>Lim Jing</firstname><surname>Xuan</surname><order>4</order></author><author><firstname>Leong Jia</firstname><surname>Yun</surname><order>5</order></author><author><firstname>Lim Jing</firstname><surname>En</surname><order>6</order></author><author><firstname>Dinesh Sangarran</firstname><surname>Ramachandram</surname><order>7</order></author><author><firstname>Angelina</firstname><surname>Lim</surname><order>8</order></author><author><firstname>Juman Abdulelah</firstname><surname>Dujaili</surname><order>9</order></author><author><firstname>Ali</firstname><surname>Blebil</surname><orcid>0000-0002-7480-1260</orcid><order>10</order></author></authors><documents><document><filename>69616__34375__d9bd5ba426c54dedb8d69999a2142231.pdf</filename><originalFilename>69616.VoR.pdf</originalFilename><uploaded>2025-06-02T12:46:24.0986794</uploaded><type>Output</type><contentLength>659665</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; 2025 Mohammed et al. 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spelling 2025-06-02T12:52:46.2203846 v2 69616 2025-06-02 Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care ae3f126adda1dec7b84f0a12698f0b7d 0000-0002-7480-1260 Ali Blebil Ali Blebil true false 2025-06-02 MEDS BackgroundCancer patients who receive immunosuppressive therapy are vulnerable to infections due to their compromised immune systems. Therefore, research in promoting the prudent use of antibiotics in this population is essential to optimise patient outcomes and reduce resistance development. The purpose of this study is to develop and validate the Knowledge and Practice of Antimicrobial Stewardship in the Oncology Care Questionnaire (KP-AMS-OC-Q).MethodThis research is performed in 2 phases. Phase I includes the questionnaire development, item generation, content validity and pilot testing. Phase II encompasses the dissemination of questionnaires to hospital pharmacists and the psychometric evaluation of the validation and reliability of KP-AMS-OC-Q. Specifically, IRT is used to evaluate the knowledge domains, EFA for the practice domains, and Cronbach alpha to measure reliability.ResultThe finalised version of the questionnaire consisted of 112 items, including 7 social demographics, 49 knowledge, and 56 practice items. IRT conducted has revealed an acceptable difficulty parameter (-3 to +3) in the knowledge domain. Furthermore, EFA has shown a strong internal association between the items and factors, with each item reaching the minimum acceptable factor loading value (>0.3). Besides this, the internal consistency of this questionnaire is favourable, indicated by the Cronbach alpha coefficient of 0.899.ConclusionThe results of this study have validated that KP-AMS-OC-Q possesses exceptional psychometric qualities, making it appropriate to measure pharmacists’ knowledge and practice towards antimicrobial stewardship (AMS) in oncology care. Journal Article PLOS One 20 5 e0321551 Public Library of Science (PLoS) 1932-6203 1932-6203 23 5 2025 2025-05-23 10.1371/journal.pone.0321551 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University SU Library paid the OA fee (TA Institutional Deal) The author(s) received no specific funding for this work. 2025-06-02T12:52:46.2203846 2025-06-02T12:43:34.2819382 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Ali Haider Mohammed 1 Bassam Abdul Rasool Hassan 0000-0001-5822-0442 2 Lim Jie Sern 3 Lim Jing Xuan 4 Leong Jia Yun 5 Lim Jing En 6 Dinesh Sangarran Ramachandram 7 Angelina Lim 8 Juman Abdulelah Dujaili 9 Ali Blebil 0000-0002-7480-1260 10 69616__34375__d9bd5ba426c54dedb8d69999a2142231.pdf 69616.VoR.pdf 2025-06-02T12:46:24.0986794 Output 659665 application/pdf Version of Record true © 2025 Mohammed et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care
spellingShingle Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care
Ali Blebil
title_short Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care
title_full Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care
title_fullStr Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care
title_full_unstemmed Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care
title_sort Development and validation of a questionnaire assessing pharmacists' knowledge and practice towards antimicrobial stewardship in oncology care
author_id_str_mv ae3f126adda1dec7b84f0a12698f0b7d
author_id_fullname_str_mv ae3f126adda1dec7b84f0a12698f0b7d_***_Ali Blebil
author Ali Blebil
author2 Ali Haider Mohammed
Bassam Abdul Rasool Hassan
Lim Jie Sern
Lim Jing Xuan
Leong Jia Yun
Lim Jing En
Dinesh Sangarran Ramachandram
Angelina Lim
Juman Abdulelah Dujaili
Ali Blebil
format Journal article
container_title PLOS One
container_volume 20
container_issue 5
container_start_page e0321551
publishDate 2025
institution Swansea University
issn 1932-6203
1932-6203
doi_str_mv 10.1371/journal.pone.0321551
publisher Public Library of Science (PLoS)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
document_store_str 1
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description BackgroundCancer patients who receive immunosuppressive therapy are vulnerable to infections due to their compromised immune systems. Therefore, research in promoting the prudent use of antibiotics in this population is essential to optimise patient outcomes and reduce resistance development. The purpose of this study is to develop and validate the Knowledge and Practice of Antimicrobial Stewardship in the Oncology Care Questionnaire (KP-AMS-OC-Q).MethodThis research is performed in 2 phases. Phase I includes the questionnaire development, item generation, content validity and pilot testing. Phase II encompasses the dissemination of questionnaires to hospital pharmacists and the psychometric evaluation of the validation and reliability of KP-AMS-OC-Q. Specifically, IRT is used to evaluate the knowledge domains, EFA for the practice domains, and Cronbach alpha to measure reliability.ResultThe finalised version of the questionnaire consisted of 112 items, including 7 social demographics, 49 knowledge, and 56 practice items. IRT conducted has revealed an acceptable difficulty parameter (-3 to +3) in the knowledge domain. Furthermore, EFA has shown a strong internal association between the items and factors, with each item reaching the minimum acceptable factor loading value (>0.3). Besides this, the internal consistency of this questionnaire is favourable, indicated by the Cronbach alpha coefficient of 0.899.ConclusionThe results of this study have validated that KP-AMS-OC-Q possesses exceptional psychometric qualities, making it appropriate to measure pharmacists’ knowledge and practice towards antimicrobial stewardship (AMS) in oncology care.
published_date 2025-05-23T06:47:27Z
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