Novel stereo DIC characterisation of microneedle and hypodermic needle insertion

McNamee, Megan; Pritchard, Tom; Mitchell, Jacob; Bolton, Chris; Roberts, Kerry; Guy, Owen; Ashraf, Huma; Arora, Hari

doi:10.3389/fbioe.2025.1580464

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Novel stereo DIC characterisation of microneedle and hypodermic needle insertion

Megan McNamee, Tom Pritchard, Jacob Mitchell, Chris Bolton, Kerry Roberts, Owen Guy

, Huma Ashraf, Hari Arora

Frontiers in Bioengineering and Biotechnology, Volume: 13

Swansea University Authors: Megan McNamee, Tom Pritchard, Owen Guy , Hari Arora

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© 2025 McNamee, Pritchard, Mitchell, Bolton, Roberts, Guy, Ashraf and Arora. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY).
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DOI (Published version): 10.3389/fbioe.2025.1580464

Abstract

Microneedles are minimally invasive devices, designed for pain-free drug delivery. Until now, the degree of strain exerted on the skin during microneedle insertion, in comparison to gold standard hypodermic needles, has not been quantified. This paper presents experimental results from a novel digit...

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Published in:	Frontiers in Bioengineering and Biotechnology
ISSN:	2296-4185
Published:	Frontiers Media SA 2025
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa69546

first_indexed	2025-05-21T08:11:04Z
last_indexed	2025-07-04T06:42:04Z
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Until now, the degree of strain exerted on the skin during microneedle insertion, in comparison to gold standard hypodermic needles, has not been quantified. This paper presents experimental results from a novel digital image correlation setup to quantify maximum normal strain exerted on a skin-mimicking membrane by hollow silicon microneedles and 25-gauge stainless steel hypodermic needles through contact, deformation, rupture, and device insertion. Findings here have shown 1x5 hollow silicon microneedle arrays exert significantly lower maximum normal strain compared to 25-gauge hypodermic needles. There is an average of 75% decrease in the maximum normal strain experienced by the membrane when using microneedle devices in comparison to that of the 25-gauge hypodermic needles. This quantification of strain has been discretised to each individual needle in the microneedle device, allowing for informed design choices for future device iterations. 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spelling	2025-07-03T14:21:22.1741965 v2 69546 2025-05-21 Novel stereo DIC characterisation of microneedle and hypodermic needle insertion c3f02aa2478f79f98cd969fbd002dc59 Megan McNamee Megan McNamee true false ca3aa35fb1034cdbeb740f8fbead4817 Tom Pritchard Tom Pritchard true false c7fa5949b8528e048c5b978005f66794 0000-0002-6449-4033 Owen Guy Owen Guy true false ed7371c768e9746008a6807f9f7a1555 0000-0002-9790-0907 Hari Arora Hari Arora true false 2025-05-21 OICWS Microneedles are minimally invasive devices, designed for pain-free drug delivery. Until now, the degree of strain exerted on the skin during microneedle insertion, in comparison to gold standard hypodermic needles, has not been quantified. This paper presents experimental results from a novel digital image correlation setup to quantify maximum normal strain exerted on a skin-mimicking membrane by hollow silicon microneedles and 25-gauge stainless steel hypodermic needles through contact, deformation, rupture, and device insertion. Findings here have shown 1x5 hollow silicon microneedle arrays exert significantly lower maximum normal strain compared to 25-gauge hypodermic needles. There is an average of 75% decrease in the maximum normal strain experienced by the membrane when using microneedle devices in comparison to that of the 25-gauge hypodermic needles. This quantification of strain has been discretised to each individual needle in the microneedle device, allowing for informed design choices for future device iterations. These findings suggest the hollow microneedle devices to be a gentler alternative for transdermal applications, potentially improving patient comfort and reducing tissue trauma when compared to the gold standard, traditional 25-gauge hypodermic needle. Journal Article Frontiers in Bioengineering and Biotechnology 13 Frontiers Media SA 2296-4185 microneedle (MN), DIC (digital image correlation), strain, skin phantom, needle insertion 30 6 2025 2025-06-30 10.3389/fbioe.2025.1580464 COLLEGE NANME The College, Swansea University COLLEGE CODE OICWS Swansea University External research funder(s) paid the OA fee (includes OA grants disbursed by the Library) UKRI (EP/S02252X/1) 2025-07-03T14:21:22.1741965 2025-05-21T09:06:42.0564809 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Megan McNamee 1 Tom Pritchard 2 Jacob Mitchell 3 Chris Bolton 4 Kerry Roberts 5 Owen Guy 0000-0002-6449-4033 6 Huma Ashraf 7 Hari Arora 0000-0002-9790-0907 8 69546__34665__0582b68b1b5847f68a71fb60c0aa295c.pdf 69546.VoR.pdf 2025-07-03T14:19:03.7985805 Output 3041817 application/pdf Version of Record true © 2025 McNamee, Pritchard, Mitchell, Bolton, Roberts, Guy, Ashraf and Arora. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY). true eng https://creativecommons.org/licenses/by/4.0/
title	Novel stereo DIC characterisation of microneedle and hypodermic needle insertion
spellingShingle	Novel stereo DIC characterisation of microneedle and hypodermic needle insertion Megan McNamee Tom Pritchard Owen Guy Hari Arora
title_short	Novel stereo DIC characterisation of microneedle and hypodermic needle insertion
title_full	Novel stereo DIC characterisation of microneedle and hypodermic needle insertion
title_fullStr	Novel stereo DIC characterisation of microneedle and hypodermic needle insertion
title_full_unstemmed	Novel stereo DIC characterisation of microneedle and hypodermic needle insertion
title_sort	Novel stereo DIC characterisation of microneedle and hypodermic needle insertion
author_id_str_mv	c3f02aa2478f79f98cd969fbd002dc59 ca3aa35fb1034cdbeb740f8fbead4817 c7fa5949b8528e048c5b978005f66794 ed7371c768e9746008a6807f9f7a1555
author_id_fullname_str_mv	c3f02aa2478f79f98cd969fbd002dc59_*_Megan McNamee ca3aa35fb1034cdbeb740f8fbead4817__Tom Pritchard c7fa5949b8528e048c5b978005f66794__Owen Guy ed7371c768e9746008a6807f9f7a1555_*_Hari Arora
author	Megan McNamee Tom Pritchard Owen Guy Hari Arora
author2	Megan McNamee Tom Pritchard Jacob Mitchell Chris Bolton Kerry Roberts Owen Guy Huma Ashraf Hari Arora
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container_title	Frontiers in Bioengineering and Biotechnology
container_volume	13
publishDate	2025
institution	Swansea University
issn	2296-4185
doi_str_mv	10.3389/fbioe.2025.1580464
publisher	Frontiers Media SA
college_str	Faculty of Science and Engineering
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hierarchy_top_id	facultyofscienceandengineering
hierarchy_top_title	Faculty of Science and Engineering
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department_str	School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
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description	Microneedles are minimally invasive devices, designed for pain-free drug delivery. Until now, the degree of strain exerted on the skin during microneedle insertion, in comparison to gold standard hypodermic needles, has not been quantified. This paper presents experimental results from a novel digital image correlation setup to quantify maximum normal strain exerted on a skin-mimicking membrane by hollow silicon microneedles and 25-gauge stainless steel hypodermic needles through contact, deformation, rupture, and device insertion. Findings here have shown 1x5 hollow silicon microneedle arrays exert significantly lower maximum normal strain compared to 25-gauge hypodermic needles. There is an average of 75% decrease in the maximum normal strain experienced by the membrane when using microneedle devices in comparison to that of the 25-gauge hypodermic needles. This quantification of strain has been discretised to each individual needle in the microneedle device, allowing for informed design choices for future device iterations. These findings suggest the hollow microneedle devices to be a gentler alternative for transdermal applications, potentially improving patient comfort and reducing tissue trauma when compared to the gold standard, traditional 25-gauge hypodermic needle.
published_date	2025-06-30T05:28:28Z
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score	11.089386

Novel stereo DIC characterisation of microneedle and hypodermic needle insertion

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