Using N‐Nitrosodiethanolamine (NDELA) and N‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data

Roper, Jason M.; Griffin, Troy R.; Johnson, George; Kostal, Jakub; Nudelman, Raphael; Ott, Gregory R.; Voutchkova‐Kostal, Adelina; Niddam‐Hildesheim, Valerie

doi:10.1002/em.70012

Journal article 251 views 159 downloads

Using N‐Nitrosodiethanolamine (NDELA) and N‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinoge...

Jason M. Roper

, Troy R. Griffin, George Johnson

, Jakub Kostal, Raphael Nudelman, Gregory R. Ott, Adelina Voutchkova‐Kostal, Valerie Niddam‐Hildesheim

Environmental and Molecular Mutagenesis, Volume: 66, Issue: 4, Pages: 155 - 171

Swansea University Author: George Johnson

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DOI (Published version): 10.1002/em.70012

Published in:	Environmental and Molecular Mutagenesis
ISSN:	0893-6692 1098-2280
Published:	Wiley 2025
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa69450

first_indexed	2025-05-08T16:01:32Z
last_indexed	2025-06-19T10:46:34Z
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spelling	2025-06-18T10:34:23.4190522 v2 69450 2025-05-08 Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data 37d0f121db69fd09f364df89e4405e31 0000-0001-5643-9942 George Johnson George Johnson true false 2025-05-08 MEDS Journal Article Environmental and Molecular Mutagenesis 66 4 155 171 Wiley 0893-6692 1098-2280 benchmark dose, critical effect size, nitrosamine, risk assessment, TGR 8 5 2025 2025-05-08 10.1002/em.70012 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Not Required Teva Pharmaceutical Industries Ltd. 2025-06-18T10:34:23.4190522 2025-05-08T12:14:36.6071469 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Jason M. Roper 0000-0002-3594-666x 1 Troy R. Griffin 2 George Johnson 0000-0001-5643-9942 3 Jakub Kostal 4 Raphael Nudelman 5 Gregory R. Ott 6 Adelina Voutchkova‐Kostal 7 Valerie Niddam‐Hildesheim 8 69450__34505__efd3d9fa040e484e84fd9b3562fba157.pdf 69450.AAM.pdf 2025-06-18T10:29:05.1068350 Output 529713 application/pdf Accepted Manuscript true Author accepted manuscript document released under the terms of a Creative Commons CC-BY licence using the Swansea University Research Publications Policy (rights retention). true eng https://creativecommons.org/licenses/by/4.0/
title	Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data
spellingShingle	Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data George Johnson
title_short	Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data
title_full	Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data
title_fullStr	Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data
title_full_unstemmed	Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data
title_sort	Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data
author_id_str_mv	37d0f121db69fd09f364df89e4405e31
author_id_fullname_str_mv	37d0f121db69fd09f364df89e4405e31_***_George Johnson
author	George Johnson
author2	Jason M. Roper Troy R. Griffin George Johnson Jakub Kostal Raphael Nudelman Gregory R. Ott Adelina Voutchkova‐Kostal Valerie Niddam‐Hildesheim
format	Journal article
container_title	Environmental and Molecular Mutagenesis
container_volume	66
container_issue	4
container_start_page	155
publishDate	2025
institution	Swansea University
issn	0893-6692 1098-2280
doi_str_mv	10.1002/em.70012
publisher	Wiley
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
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published_date	2025-05-08T05:28:13Z
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Using <i>N</i>‐Nitrosodiethanolamine (NDELA) and <i>N</i>‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinoge...

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