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Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile
Vera Logan,
Neil Carter,
David Hughes,
Adam Turner 
,
Sue Jordan
,
Sue Jordan
Journal of Nursing Management, Volume: 2025, Issue: 1
Swansea University Authors:
Vera Logan, Neil Carter, David Hughes, Adam Turner , Sue Jordan
-
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Copyright © 2025 Vera Logan et al. This is an open access article under the terms of the Creative Commons Attribution License.
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DOI (Published version): 10.1155/jonm/9921349
Abstract
Background: Adverse drug reactions (ADRs), particularly in the context of polypharmacy, remain a persistent, unresolved problem for patients and healthcare professionals. The ADRe Profile identifies medicine-related harms, and supports their resolution, thereby improving care quality and preventing...
| Published in: | Journal of Nursing Management |
|---|---|
| ISSN: | 0966-0429 1365-2834 |
| Published: |
Wiley
2025
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa69340 |
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2025-04-24T10:07:48Z |
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2025-05-16T09:44:55Z |
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<?xml version="1.0"?><rfc1807><datestamp>2025-05-15T13:40:43.3003490</datestamp><bib-version>v2</bib-version><id>69340</id><entry>2025-04-24</entry><title>Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile</title><swanseaauthors><author><sid>89a4cb1af023b1d80dce90a417a94585</sid><firstname>Vera</firstname><surname>Logan</surname><name>Vera Logan</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>9a3f8cbd9ad25966c489e44fabed844f</sid><firstname>Neil</firstname><surname>Carter</surname><name>Neil Carter</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>f1fbd458e3c75d8b597c0ac8036f2b88</sid><firstname>David</firstname><surname>Hughes</surname><name>David Hughes</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>486394f1fb20386cbf02509e4a70ddd4</sid><ORCID>0000-0002-0721-7662</ORCID><firstname>Adam</firstname><surname>Turner</surname><name>Adam Turner</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>24ce9db29b4bde1af4e83b388aae0ea1</sid><firstname>Sue</firstname><surname>Jordan</surname><name>Sue Jordan</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2025-04-24</date><abstract>Background: Adverse drug reactions (ADRs), particularly in the context of polypharmacy, remain a persistent, unresolved problem for patients and healthcare professionals. The ADRe Profile identifies medicine-related harms, and supports their resolution, thereby improving care quality and preventing future problems.Objective: The objective of this study was to assess the validity and reliability of the ADRe Profile (https://www.swansea.ac.uk/adre/) in U.K. primary care general practices, building on assessments in other settings.Methods: The ADRe Profile’s validity and reliability were investigated using complementary mixed methods: content validity index, contrast group construct validity, cognitive interviewing, and inter-rater reliability.Results: Cognitive interviews (n = 5) confirmed that the ADRe Profile needed only minor adjustments. The scale-level content validity index was 0.67 (n = 14), items ranging from 0.08 to 1. Significant differences in signs and symptoms associated with ADRs between service users taking different numbers of regular prescribed medicines confirmed construct validity (n = 68, U = 870.50, p < 0.001). Inter-rater reliability testing showed substantial agreement between service users and research nurse: 10 items had 100% agreement. Overall kappa mean was 0.71 (range: 0.31–1), (n = 42).Conclusions and Relevance: The ADRe Profile is suitable for use with older service users in primary care who live at home. Users understood the questions and provided meaningful answers. ADRe Profile responses were sufficiently reliable to be used as a basis for further investigations, prescriber referral and clinical actions. However, clinician judgement of content validity may depend on knowledge and experience, highlighting the importance of training. Clinicians acknowledged that the ADRe Profile was comprehensive but identified practical difficulties. Instruments to reduce ADRs should be validated before testing in feasibility studies and randomised controlled trials.Implications for Nursing Management: Managers need to optimise patient safety by introducing patient-centred symptom monitoring, with decision support. 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This is an open access article under the terms of the Creative Commons Attribution License.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807> |
| spelling |
2025-05-15T13:40:43.3003490 v2 69340 2025-04-24 Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile 89a4cb1af023b1d80dce90a417a94585 Vera Logan Vera Logan true false 9a3f8cbd9ad25966c489e44fabed844f Neil Carter Neil Carter true false f1fbd458e3c75d8b597c0ac8036f2b88 David Hughes David Hughes true false 486394f1fb20386cbf02509e4a70ddd4 0000-0002-0721-7662 Adam Turner Adam Turner true false 24ce9db29b4bde1af4e83b388aae0ea1 Sue Jordan Sue Jordan true false 2025-04-24 Background: Adverse drug reactions (ADRs), particularly in the context of polypharmacy, remain a persistent, unresolved problem for patients and healthcare professionals. The ADRe Profile identifies medicine-related harms, and supports their resolution, thereby improving care quality and preventing future problems.Objective: The objective of this study was to assess the validity and reliability of the ADRe Profile (https://www.swansea.ac.uk/adre/) in U.K. primary care general practices, building on assessments in other settings.Methods: The ADRe Profile’s validity and reliability were investigated using complementary mixed methods: content validity index, contrast group construct validity, cognitive interviewing, and inter-rater reliability.Results: Cognitive interviews (n = 5) confirmed that the ADRe Profile needed only minor adjustments. The scale-level content validity index was 0.67 (n = 14), items ranging from 0.08 to 1. Significant differences in signs and symptoms associated with ADRs between service users taking different numbers of regular prescribed medicines confirmed construct validity (n = 68, U = 870.50, p < 0.001). Inter-rater reliability testing showed substantial agreement between service users and research nurse: 10 items had 100% agreement. Overall kappa mean was 0.71 (range: 0.31–1), (n = 42).Conclusions and Relevance: The ADRe Profile is suitable for use with older service users in primary care who live at home. Users understood the questions and provided meaningful answers. ADRe Profile responses were sufficiently reliable to be used as a basis for further investigations, prescriber referral and clinical actions. However, clinician judgement of content validity may depend on knowledge and experience, highlighting the importance of training. Clinicians acknowledged that the ADRe Profile was comprehensive but identified practical difficulties. Instruments to reduce ADRs should be validated before testing in feasibility studies and randomised controlled trials.Implications for Nursing Management: Managers need to optimise patient safety by introducing patient-centred symptom monitoring, with decision support. Before instruments are adopted, managers should check the reliability and validity data.Trial Registration: ClinicalTrials.gov identifier: NCT04663360 Journal Article Journal of Nursing Management 2025 1 Wiley 0966-0429 1365-2834 drug-related side efects and adverse reactions; pharmacovigilance; primary health care; validation study 14 5 2025 2025-05-14 10.1155/jonm/9921349 COLLEGE NANME COLLEGE CODE Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University 2025-05-15T13:40:43.3003490 2025-04-24T11:04:22.1818383 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing Vera Logan 1 Neil Carter 2 David Hughes 3 Adam Turner 0000-0002-0721-7662 4 Sue Jordan 5 69340__34287__063c8e8fd5f84786be81411543fa40d0.pdf 69340.VoR.pdf 2025-05-15T13:29:39.1538987 Output 562712 application/pdf Version of Record true Copyright © 2025 Vera Logan et al. This is an open access article under the terms of the Creative Commons Attribution License. true eng https://creativecommons.org/licenses/by/4.0/ |
| title |
Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile |
| spellingShingle |
Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile Vera Logan Neil Carter David Hughes Adam Turner Sue Jordan |
| title_short |
Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile |
| title_full |
Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile |
| title_fullStr |
Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile |
| title_full_unstemmed |
Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile |
| title_sort |
Reducing Adverse Drug Reactions for Older People in the Community: Evaluating the Validity and Reliability of the ADRe Profile |
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89a4cb1af023b1d80dce90a417a94585 9a3f8cbd9ad25966c489e44fabed844f f1fbd458e3c75d8b597c0ac8036f2b88 486394f1fb20386cbf02509e4a70ddd4 24ce9db29b4bde1af4e83b388aae0ea1 |
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89a4cb1af023b1d80dce90a417a94585_***_Vera Logan 9a3f8cbd9ad25966c489e44fabed844f_***_Neil Carter f1fbd458e3c75d8b597c0ac8036f2b88_***_David Hughes 486394f1fb20386cbf02509e4a70ddd4_***_Adam Turner 24ce9db29b4bde1af4e83b388aae0ea1_***_Sue Jordan |
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Vera Logan Neil Carter David Hughes Adam Turner Sue Jordan |
| author2 |
Vera Logan Neil Carter David Hughes Adam Turner Sue Jordan |
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Journal of Nursing Management |
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Swansea University |
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0966-0429 1365-2834 |
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10.1155/jonm/9921349 |
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Wiley |
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Faculty of Medicine, Health and Life Sciences |
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Faculty of Medicine, Health and Life Sciences |
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School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing |
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Background: Adverse drug reactions (ADRs), particularly in the context of polypharmacy, remain a persistent, unresolved problem for patients and healthcare professionals. The ADRe Profile identifies medicine-related harms, and supports their resolution, thereby improving care quality and preventing future problems.Objective: The objective of this study was to assess the validity and reliability of the ADRe Profile (https://www.swansea.ac.uk/adre/) in U.K. primary care general practices, building on assessments in other settings.Methods: The ADRe Profile’s validity and reliability were investigated using complementary mixed methods: content validity index, contrast group construct validity, cognitive interviewing, and inter-rater reliability.Results: Cognitive interviews (n = 5) confirmed that the ADRe Profile needed only minor adjustments. The scale-level content validity index was 0.67 (n = 14), items ranging from 0.08 to 1. Significant differences in signs and symptoms associated with ADRs between service users taking different numbers of regular prescribed medicines confirmed construct validity (n = 68, U = 870.50, p < 0.001). Inter-rater reliability testing showed substantial agreement between service users and research nurse: 10 items had 100% agreement. Overall kappa mean was 0.71 (range: 0.31–1), (n = 42).Conclusions and Relevance: The ADRe Profile is suitable for use with older service users in primary care who live at home. Users understood the questions and provided meaningful answers. ADRe Profile responses were sufficiently reliable to be used as a basis for further investigations, prescriber referral and clinical actions. However, clinician judgement of content validity may depend on knowledge and experience, highlighting the importance of training. Clinicians acknowledged that the ADRe Profile was comprehensive but identified practical difficulties. Instruments to reduce ADRs should be validated before testing in feasibility studies and randomised controlled trials.Implications for Nursing Management: Managers need to optimise patient safety by introducing patient-centred symptom monitoring, with decision support. Before instruments are adopted, managers should check the reliability and validity data.Trial Registration: ClinicalTrials.gov identifier: NCT04663360 |
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2025-05-14T05:27:55Z |
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11.089386 |