No Cover Image

Journal article 335 views 107 downloads

Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube

Rob Daniels Orcid Logo

Europhysics Letters, Volume: 150, Issue: 3, Start page: 37002

Swansea University Author: Rob Daniels Orcid Logo

  • 69322.VoR.pdf

    PDF | Version of Record

    Copyright: 2025 The author(s). Published by the EPLA under the terms of the Creative Commons Attribution 4.0 International License (CC BY).

    Download (344.15KB)

Check full text

DOI (Published version): 10.1209/0295-5075/adcf4a

Abstract

We investigate theoretically the role of thermal fluctuations, and imposed fluid flow, on the paradigmatic properties of a highly confined membrane vesicle inside a very narrow capillary tube. We quantitatively find that the size of the slender gap between a tightly fitting incompressible vesicle an...

Full description

Published in: Europhysics Letters
ISSN: 0295-5075 1286-4854
Published: IOP Publishing 2025
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa69322
first_indexed 2025-04-23T09:50:22Z
last_indexed 2025-05-20T06:52:10Z
id cronfa69322
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2025-05-19T14:57:32.9813478</datestamp><bib-version>v2</bib-version><id>69322</id><entry>2025-04-23</entry><title>Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube</title><swanseaauthors><author><sid>23f38c3bb732d4378986bdfaf7b6ee51</sid><ORCID>0000-0002-6933-8144</ORCID><firstname>Rob</firstname><surname>Daniels</surname><name>Rob Daniels</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2025-04-23</date><deptcode>EAAS</deptcode><abstract>We investigate theoretically the role of thermal fluctuations, and imposed fluid flow, on the paradigmatic properties of a highly confined membrane vesicle inside a very narrow capillary tube. We quantitatively find that the size of the slender gap between a tightly fitting incompressible vesicle and an enclosing cylindrical tube depends on a subtle interplay between membrane area dilation, vesicle fluctuations, and capillary fluid flow. It is found that in the fluid flow dominated regime, the gap size grows with increasing fluid velocity as a power law, and we are able to calculate the extra hydrodynamic pressure drop due to the presence of the vesicle, as well as the vesicle's relative mobility. Alternatively, below a critical fluid velocity, we find that for the vesicle fluctuation dominated regime the gap size becomes essentially independent of fluid flow. This work is therefore likely to be of crucial importance for considerations of the stalling and dynamic arrest of tightly confined vesicles in narrow constrictions. Possible applications of this work might thus also include biological transport, microfluidics, and drug delivery.</abstract><type>Journal Article</type><journal>Europhysics Letters</journal><volume>150</volume><journalNumber>3</journalNumber><paginationStart>37002</paginationStart><paginationEnd/><publisher>IOP Publishing</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0295-5075</issnPrint><issnElectronic>1286-4854</issnElectronic><keywords/><publishedDay>6</publishedDay><publishedMonth>5</publishedMonth><publishedYear>2025</publishedYear><publishedDate>2025-05-06</publishedDate><doi>10.1209/0295-5075/adcf4a</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><funders>Swansea University</funders><projectreference/><lastEdited>2025-05-19T14:57:32.9813478</lastEdited><Created>2025-04-23T10:46:40.1363891</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Materials Science and Engineering</level></path><authors><author><firstname>Rob</firstname><surname>Daniels</surname><orcid>0000-0002-6933-8144</orcid><order>1</order></author></authors><documents><document><filename>69322__34308__3e026c6e1c61418aa32fe4c1c2255208.pdf</filename><originalFilename>69322.VoR.pdf</originalFilename><uploaded>2025-05-19T14:54:32.9209520</uploaded><type>Output</type><contentLength>352411</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Copyright: 2025 The author(s). Published by the EPLA under the terms of the Creative Commons Attribution 4.0 International License (CC BY).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0</licence></document></documents><OutputDurs/></rfc1807>
spelling 2025-05-19T14:57:32.9813478 v2 69322 2025-04-23 Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube 23f38c3bb732d4378986bdfaf7b6ee51 0000-0002-6933-8144 Rob Daniels Rob Daniels true false 2025-04-23 EAAS We investigate theoretically the role of thermal fluctuations, and imposed fluid flow, on the paradigmatic properties of a highly confined membrane vesicle inside a very narrow capillary tube. We quantitatively find that the size of the slender gap between a tightly fitting incompressible vesicle and an enclosing cylindrical tube depends on a subtle interplay between membrane area dilation, vesicle fluctuations, and capillary fluid flow. It is found that in the fluid flow dominated regime, the gap size grows with increasing fluid velocity as a power law, and we are able to calculate the extra hydrodynamic pressure drop due to the presence of the vesicle, as well as the vesicle's relative mobility. Alternatively, below a critical fluid velocity, we find that for the vesicle fluctuation dominated regime the gap size becomes essentially independent of fluid flow. This work is therefore likely to be of crucial importance for considerations of the stalling and dynamic arrest of tightly confined vesicles in narrow constrictions. Possible applications of this work might thus also include biological transport, microfluidics, and drug delivery. Journal Article Europhysics Letters 150 3 37002 IOP Publishing 0295-5075 1286-4854 6 5 2025 2025-05-06 10.1209/0295-5075/adcf4a COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University 2025-05-19T14:57:32.9813478 2025-04-23T10:46:40.1363891 Faculty of Science and Engineering School of Engineering and Applied Sciences - Materials Science and Engineering Rob Daniels 0000-0002-6933-8144 1 69322__34308__3e026c6e1c61418aa32fe4c1c2255208.pdf 69322.VoR.pdf 2025-05-19T14:54:32.9209520 Output 352411 application/pdf Version of Record true Copyright: 2025 The author(s). Published by the EPLA under the terms of the Creative Commons Attribution 4.0 International License (CC BY). true eng https://creativecommons.org/licenses/by/4.0
title Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube
spellingShingle Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube
Rob Daniels
title_short Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube
title_full Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube
title_fullStr Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube
title_full_unstemmed Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube
title_sort Strong confinement, thermal fluctuations, and mobility of a tightly fitting vesicle in a very narrow microcapillary tube
author_id_str_mv 23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 23f38c3bb732d4378986bdfaf7b6ee51_***_Rob Daniels
author Rob Daniels
author2 Rob Daniels
format Journal article
container_title Europhysics Letters
container_volume 150
container_issue 3
container_start_page 37002
publishDate 2025
institution Swansea University
issn 0295-5075
1286-4854
doi_str_mv 10.1209/0295-5075/adcf4a
publisher IOP Publishing
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Materials Science and Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Materials Science and Engineering
document_store_str 1
active_str 0
description We investigate theoretically the role of thermal fluctuations, and imposed fluid flow, on the paradigmatic properties of a highly confined membrane vesicle inside a very narrow capillary tube. We quantitatively find that the size of the slender gap between a tightly fitting incompressible vesicle and an enclosing cylindrical tube depends on a subtle interplay between membrane area dilation, vesicle fluctuations, and capillary fluid flow. It is found that in the fluid flow dominated regime, the gap size grows with increasing fluid velocity as a power law, and we are able to calculate the extra hydrodynamic pressure drop due to the presence of the vesicle, as well as the vesicle's relative mobility. Alternatively, below a critical fluid velocity, we find that for the vesicle fluctuation dominated regime the gap size becomes essentially independent of fluid flow. This work is therefore likely to be of crucial importance for considerations of the stalling and dynamic arrest of tightly confined vesicles in narrow constrictions. Possible applications of this work might thus also include biological transport, microfluidics, and drug delivery.
published_date 2025-05-06T05:23:37Z
_version_ 1851641159549452288
score 11.089988

Similar Items