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Human Substantia Nigra Neurons Encode Unexpected Financial Rewards

K. A Zaghloul, J. A Blanco, C. T Weidemann, K McGill, J. L Jaggi, G. H Baltuch, M. J Kahana, Christoph Weidemann

Science, Volume: 323, Issue: 5920, Pages: 1496 - 1499

Swansea University Author: Christoph Weidemann

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DOI (Published version): 10.1126/science.1167342

Abstract

The brain's sensitivity to unexpected outcomes plays a fundamental role in an organism's ability to adapt and learn new behaviors. Emerging research suggests that midbrain dopaminergic neurons encode these unexpected outcomes. We used microelectrode recordings during deep brain stimulation...

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Published in: Science
ISSN: 0036-8075 1095-9203
Published: 2009
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URI: https://cronfa.swan.ac.uk/Record/cronfa6931
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first_indexed 2013-07-23T11:55:50Z
last_indexed 2019-06-12T19:15:41Z
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spelling 2019-06-12T14:56:49.5240005 v2 6931 2012-01-28 Human Substantia Nigra Neurons Encode Unexpected Financial Rewards b155eeefe08155214e70fea25649223c Christoph Weidemann Christoph Weidemann true false 2012-01-28 FGMHL The brain's sensitivity to unexpected outcomes plays a fundamental role in an organism's ability to adapt and learn new behaviors. Emerging research suggests that midbrain dopaminergic neurons encode these unexpected outcomes. We used microelectrode recordings during deep brain stimulation surgery to study neuronal activity in the human substantia nigra (SN) while patients with Parkinson's disease engaged in a probabilistic learning task motivated by virtual financial rewards. Based on a model of the participants' expected reward, we divided trial outcomes into expected and unexpected gains and losses. SN neurons exhibited significantly higher firing rates after unexpected gains than unexpected losses. No such differences were observed after expected gains and losses. This result provides critical support for the hypothesized role of the SN in human reinforcement learning. Journal Article Science 323 5920 1496 1499 0036-8075 1095-9203 13 3 2009 2009-03-13 10.1126/science.1167342 http://cogsci.info/papers/ZaghloulEtAl2009.pdf COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2019-06-12T14:56:49.5240005 2012-01-28T20:30:55.4870000 Faculty of Medicine, Health and Life Sciences School of Psychology K. A Zaghloul 1 J. A Blanco 2 C. T Weidemann 3 K McGill 4 J. L Jaggi 5 G. H Baltuch 6 M. J Kahana 7 Christoph Weidemann 8
title Human Substantia Nigra Neurons Encode Unexpected Financial Rewards
spellingShingle Human Substantia Nigra Neurons Encode Unexpected Financial Rewards
Christoph Weidemann
title_short Human Substantia Nigra Neurons Encode Unexpected Financial Rewards
title_full Human Substantia Nigra Neurons Encode Unexpected Financial Rewards
title_fullStr Human Substantia Nigra Neurons Encode Unexpected Financial Rewards
title_full_unstemmed Human Substantia Nigra Neurons Encode Unexpected Financial Rewards
title_sort Human Substantia Nigra Neurons Encode Unexpected Financial Rewards
author_id_str_mv b155eeefe08155214e70fea25649223c
author_id_fullname_str_mv b155eeefe08155214e70fea25649223c_***_Christoph Weidemann
author Christoph Weidemann
author2 K. A Zaghloul
J. A Blanco
C. T Weidemann
K McGill
J. L Jaggi
G. H Baltuch
M. J Kahana
Christoph Weidemann
format Journal article
container_title Science
container_volume 323
container_issue 5920
container_start_page 1496
publishDate 2009
institution Swansea University
issn 0036-8075
1095-9203
doi_str_mv 10.1126/science.1167342
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
url http://cogsci.info/papers/ZaghloulEtAl2009.pdf
document_store_str 0
active_str 0
description The brain's sensitivity to unexpected outcomes plays a fundamental role in an organism's ability to adapt and learn new behaviors. Emerging research suggests that midbrain dopaminergic neurons encode these unexpected outcomes. We used microelectrode recordings during deep brain stimulation surgery to study neuronal activity in the human substantia nigra (SN) while patients with Parkinson's disease engaged in a probabilistic learning task motivated by virtual financial rewards. Based on a model of the participants' expected reward, we divided trial outcomes into expected and unexpected gains and losses. SN neurons exhibited significantly higher firing rates after unexpected gains than unexpected losses. No such differences were observed after expected gains and losses. This result provides critical support for the hypothesized role of the SN in human reinforcement learning.
published_date 2009-03-13T03:08:34Z
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score 11.016593

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