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Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer / ELEANOR WILLIAMS

Swansea University Author: ELEANOR WILLIAMS

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DOI (Published version): 10.23889/SUthesis.69068

Abstract

This thesis relates to locally advanced and locally recurrent rectal cancer (LARC and LRRC) and examines the decision-making process in patients contemplating potential surgical cure with pelvic exenteration (PE). It will determine the factors that influence the decision to undergo or to decline sur...

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Published: Swansea, Wales, UK 2025
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Hutchings, Hayley; Harries, Dean ; Harji, Deena ; Evans, Martyn
URI: https://cronfa.swan.ac.uk/Record/cronfa69068
first_indexed 2025-03-07T16:01:42Z
last_indexed 2025-03-08T05:55:21Z
id cronfa69068
recordtype RisThesis
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spelling 2025-03-07T16:34:16.2598111 v2 69068 2025-03-07 Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer dd3c59d31628cf5729b78fd63e89ffcc ELEANOR WILLIAMS ELEANOR WILLIAMS true false 2025-03-07 This thesis relates to locally advanced and locally recurrent rectal cancer (LARC and LRRC) and examines the decision-making process in patients contemplating potential surgical cure with pelvic exenteration (PE). It will determine the factors that influence the decision to undergo or to decline surgery for both patients and clinicians. The aim of this research is to produce a validated Patient Decision Aid (PtDA) for patients with LARC and LRRC to facilitate the shared decision making (SDM) process. Objectives1.To undertake a systematic literature review to identify existing validated PtDAs and grey literature including online forums for PE.2.To explore whether English patient information leaflets (PILs) exist at centres worldwide performing exenterative surgery.3.To explore through qualitative interviews patient views regarding what factors are important to them when making decisions regarding PE surgery.4.To explore through qualitative interviews with clinicians their views regarding what they perceive to be important for the patient to consider when making decisions regarding PE surgery.5.To use the findings from the literature review and qualitative interviews to inform the first stage development of a PtDA that outlines treatment options for patients with LARC or LRRC.6.To develop the PtDA using key stakeholders.7.To assess the content and face validity of the PtDA.8.To assess the reliability and validity of the PtDA.9.To assess the feasibility and efficacy of the PtDA. E-Thesis Swansea, Wales, UK Pelvic Exenteration, Locally Advanced Rectal Cancer, Locally Recurrent Rectal Cancer, Decision Making, Patient Decision Aid 27 2 2025 2025-02-27 10.23889/SUthesis.69068 COLLEGE NANME COLLEGE CODE Swansea University Hutchings, Hayley; Harries, Dean ; Harji, Deena ; Evans, Martyn Doctoral Ph.D Bowel research UK and Pathway to Portfolio Scheme Bowel research UK and Pathway to Portfolio Scheme 2025-03-07T16:34:16.2598111 2025-03-07T15:50:08.0124367 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science ELEANOR WILLIAMS 1 69068__33769__82c6bdc3ddcd41289d316dcbbbb6581f.pdf Williams_Eleanor_PhD_Thesis_Final_Cronfa.pdf 2025-03-07T16:30:28.1054722 Output 11740671 application/pdf E-Thesis – open access true Copyright: The Author, Eleanor Anwen Williams, 2025. true eng
title Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer
spellingShingle Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer
ELEANOR WILLIAMS
title_short Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer
title_full Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer
title_fullStr Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer
title_full_unstemmed Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer
title_sort Decision making in pelvic exenteration for locally advanced and locally recurrent rectal cancer
author_id_str_mv dd3c59d31628cf5729b78fd63e89ffcc
author_id_fullname_str_mv dd3c59d31628cf5729b78fd63e89ffcc_***_ELEANOR WILLIAMS
author ELEANOR WILLIAMS
author2 ELEANOR WILLIAMS
format E-Thesis
publishDate 2025
institution Swansea University
doi_str_mv 10.23889/SUthesis.69068
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
active_str 0
description This thesis relates to locally advanced and locally recurrent rectal cancer (LARC and LRRC) and examines the decision-making process in patients contemplating potential surgical cure with pelvic exenteration (PE). It will determine the factors that influence the decision to undergo or to decline surgery for both patients and clinicians. The aim of this research is to produce a validated Patient Decision Aid (PtDA) for patients with LARC and LRRC to facilitate the shared decision making (SDM) process. Objectives1.To undertake a systematic literature review to identify existing validated PtDAs and grey literature including online forums for PE.2.To explore whether English patient information leaflets (PILs) exist at centres worldwide performing exenterative surgery.3.To explore through qualitative interviews patient views regarding what factors are important to them when making decisions regarding PE surgery.4.To explore through qualitative interviews with clinicians their views regarding what they perceive to be important for the patient to consider when making decisions regarding PE surgery.5.To use the findings from the literature review and qualitative interviews to inform the first stage development of a PtDA that outlines treatment options for patients with LARC or LRRC.6.To develop the PtDA using key stakeholders.7.To assess the content and face validity of the PtDA.8.To assess the reliability and validity of the PtDA.9.To assess the feasibility and efficacy of the PtDA.
published_date 2025-02-27T05:27:13Z
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score 11.089407

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