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Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue / DALE KERNOT

Swansea University Author: DALE KERNOT

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DOI (Published version): 10.23889/SUThesis.69054

Abstract

Microwave ablation (MWA) therapy, a minimally invasive approach utilizing electromagnetic waves to induce cytotoxic temperatures within tumors, is the focus of this thesis. This thesis gives a comprehensive background of the theory underpinning established computational models and uses these models...

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Published: Swansea University, Wales, UK 2025
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Van Loon, R., and Arora, H.
URI: https://cronfa.swan.ac.uk/Record/cronfa69054
first_indexed 2025-03-06T15:32:31Z
last_indexed 2025-03-07T05:49:40Z
id cronfa69054
recordtype RisThesis
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spelling 2025-03-06T15:32:28.1360374 v2 69054 2025-03-06 Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue c5212b8a5f533d2032d490b234c5e90a DALE KERNOT DALE KERNOT true false 2025-03-06 Microwave ablation (MWA) therapy, a minimally invasive approach utilizing electromagnetic waves to induce cytotoxic temperatures within tumors, is the focus of this thesis. This thesis gives a comprehensive background of the theory underpinning established computational models and uses these models to perform a novel comparative analysis of various 2D MWA probe designs and to explore the efficacy of internally cooled probes. The aim is to enhance the knowledge of MWA by providing a detailed understanding of probe-tissue interactions.The initial segment of the research uses a two-dimensional axisymmetric finite element model to systematically examine different MWA probe geometries. This study specifically addresses the changes in dielectric properties of tissues at elevated temperatures and their impact on the thermal and electric field distributions. Highlighting the importance of their consideration in modelling of MWA and the transient influence they have on the shape and size of ablation fields.The second part of the thesis presents a detailed parametric study of internally cooled MWA probes. This study examines the effects of coolant system configuration, including the internal position of the cooling system, coolant flow rate, and coolant temperature on the probe’s performance. These factors are critically analyzed to determine their influence on maintaining targeted tissue heating, preventing excessive heating, and potential damage to surrounding healthy tissues.This thesis demonstrates the creation of a custom multiphysics model for microwave ablation, developed using the open-source NGSolve software. This approach enabled precise modeling of complex probe-tissue interactions, illustrating the power of open-source tools in advancing medical device research. E-Thesis Swansea University, Wales, UK Microwave ablation, Hyperthermal treatment, Numerical simulation, Bioheat 3 2 2025 2025-02-03 10.23889/SUThesis.69054 A selection of content is redacted or is partially redacted from this thesis to protect sensitive and personal information COLLEGE NANME COLLEGE CODE Swansea University Van Loon, R., and Arora, H. Doctoral Ph.D European Social Fund through the European Union’s Convergence programme administered by the Welsh Government, and Olympus Surgical Technologies Europe. European Social Fund through the European Union’s Convergence programme administered by the Welsh Government, and Olympus Surgical Technologies Europe. 2025-03-06T15:32:28.1360374 2025-03-06T15:13:46.7986163 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering DALE KERNOT 1 69054__33751__cd63edb937b142a189bdf0eaa6a7d534.pdf 2025_Kernot_D.final.69054.pdf 2025-03-06T15:23:54.2771713 Output 12234715 application/pdf E-Thesis – open access true Copyright: The Author, Dale Kernot, 2025 Distributed under the terms of a Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA 4.0). true eng https://creativecommons.org/licenses/by-sa/4.0/
title Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue
spellingShingle Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue
DALE KERNOT
title_short Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue
title_full Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue
title_fullStr Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue
title_full_unstemmed Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue
title_sort Transient Computational Analysis to Aid Microwave Ablation Device Design for Liver Tissue
author_id_str_mv c5212b8a5f533d2032d490b234c5e90a
author_id_fullname_str_mv c5212b8a5f533d2032d490b234c5e90a_***_DALE KERNOT
author DALE KERNOT
author2 DALE KERNOT
format E-Thesis
publishDate 2025
institution Swansea University
doi_str_mv 10.23889/SUThesis.69054
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering
document_store_str 1
active_str 0
description Microwave ablation (MWA) therapy, a minimally invasive approach utilizing electromagnetic waves to induce cytotoxic temperatures within tumors, is the focus of this thesis. This thesis gives a comprehensive background of the theory underpinning established computational models and uses these models to perform a novel comparative analysis of various 2D MWA probe designs and to explore the efficacy of internally cooled probes. The aim is to enhance the knowledge of MWA by providing a detailed understanding of probe-tissue interactions.The initial segment of the research uses a two-dimensional axisymmetric finite element model to systematically examine different MWA probe geometries. This study specifically addresses the changes in dielectric properties of tissues at elevated temperatures and their impact on the thermal and electric field distributions. Highlighting the importance of their consideration in modelling of MWA and the transient influence they have on the shape and size of ablation fields.The second part of the thesis presents a detailed parametric study of internally cooled MWA probes. This study examines the effects of coolant system configuration, including the internal position of the cooling system, coolant flow rate, and coolant temperature on the probe’s performance. These factors are critically analyzed to determine their influence on maintaining targeted tissue heating, preventing excessive heating, and potential damage to surrounding healthy tissues.This thesis demonstrates the creation of a custom multiphysics model for microwave ablation, developed using the open-source NGSolve software. This approach enabled precise modeling of complex probe-tissue interactions, illustrating the power of open-source tools in advancing medical device research.
published_date 2025-02-03T05:27:10Z
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score 11.089386

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