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Novel Strategies for Preventing Fungal Infections—Outline

Damilola J. Agbadamashi, Claire Price Orcid Logo

Pathogens, Volume: 14, Issue: 2, Start page: 126

Swansea University Author: Claire Price Orcid Logo

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DOI (Published version): 10.3390/pathogens14020126

Abstract

Fungal infections are a significant global health challenge, causing approximately 3.8 million deaths annually, with immunocompromised populations particularly at risk. Traditional antifungal therapies, including azoles, echinocandins, and polyenes, face limitations due to rising antifungal resistan...

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Published in: Pathogens
ISSN: 2076-0817
Published: MDPI AG 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa68886
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spelling 2025-03-25T16:46:05.9362801 v2 68886 2025-02-13 Novel Strategies for Preventing Fungal Infections—Outline 9a4e4dfa37f4318c6fa67933d4fc9a17 0000-0002-6045-4835 Claire Price Claire Price true false 2025-02-13 MEDS Fungal infections are a significant global health challenge, causing approximately 3.8 million deaths annually, with immunocompromised populations particularly at risk. Traditional antifungal therapies, including azoles, echinocandins, and polyenes, face limitations due to rising antifungal resistance, toxicity, and inadequate treatment options. This review explores innovative strategies for preventing and managing fungal infections, such as vaccines, antifungal peptides, nanotechnology, probiotics, and immunotherapy. Vaccines offer promising avenues for long-term protection, despite difficulties in their development due to fungal complexity and immune evasion mechanisms. Antifungal peptides provide a novel class of agents with broad-spectrum activity and reduced resistance risk, whilst nanotechnology enables targeted, effective drug delivery systems. Probiotics show potential in preventing fungal infections, particularly vulvovaginal candidiasis, by maintaining microbial balance. Immunotherapy leverages immune system modulation to enhance antifungal defenses, and omics technologies deliver comprehensive insights into fungal biology, paving the way for novel therapeutic and vaccine targets. While these approaches hold immense promise, challenges such as cost, accessibility, and translational barriers remain. A coordinated effort among researchers, clinicians, and policymakers is critical to advancing these strategies and addressing the global burden of fungal infections effectively. Journal Article Pathogens 14 2 126 MDPI AG 2076-0817 fungal infections; antifungal resistance; immunocompromised populations; antifungal therapies; vaccines; antifungal peptides; nanotechnology; probiotics; immunotherapy; omics technologies; global health; fungal prevention; innovative treatments; fungal biology 1 2 2025 2025-02-01 10.3390/pathogens14020126 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Other This research received no external funding. 2025-03-25T16:46:05.9362801 2025-02-13T15:52:54.4971009 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Damilola J. Agbadamashi 1 Claire Price 0000-0002-6045-4835 2 68886__33885__74922dcc714746dfb3ee82741b534ffd.pdf 68886.VoR.pdf 2025-03-25T16:43:23.9279144 Output 264317 application/pdf Version of Record true © 2025 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. true eng https://creativecommons.org/licenses/by/4.0/
title Novel Strategies for Preventing Fungal Infections—Outline
spellingShingle Novel Strategies for Preventing Fungal Infections—Outline
Claire Price
title_short Novel Strategies for Preventing Fungal Infections—Outline
title_full Novel Strategies for Preventing Fungal Infections—Outline
title_fullStr Novel Strategies for Preventing Fungal Infections—Outline
title_full_unstemmed Novel Strategies for Preventing Fungal Infections—Outline
title_sort Novel Strategies for Preventing Fungal Infections—Outline
author_id_str_mv 9a4e4dfa37f4318c6fa67933d4fc9a17
author_id_fullname_str_mv 9a4e4dfa37f4318c6fa67933d4fc9a17_***_Claire Price
author Claire Price
author2 Damilola J. Agbadamashi
Claire Price
format Journal article
container_title Pathogens
container_volume 14
container_issue 2
container_start_page 126
publishDate 2025
institution Swansea University
issn 2076-0817
doi_str_mv 10.3390/pathogens14020126
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
active_str 0
description Fungal infections are a significant global health challenge, causing approximately 3.8 million deaths annually, with immunocompromised populations particularly at risk. Traditional antifungal therapies, including azoles, echinocandins, and polyenes, face limitations due to rising antifungal resistance, toxicity, and inadequate treatment options. This review explores innovative strategies for preventing and managing fungal infections, such as vaccines, antifungal peptides, nanotechnology, probiotics, and immunotherapy. Vaccines offer promising avenues for long-term protection, despite difficulties in their development due to fungal complexity and immune evasion mechanisms. Antifungal peptides provide a novel class of agents with broad-spectrum activity and reduced resistance risk, whilst nanotechnology enables targeted, effective drug delivery systems. Probiotics show potential in preventing fungal infections, particularly vulvovaginal candidiasis, by maintaining microbial balance. Immunotherapy leverages immune system modulation to enhance antifungal defenses, and omics technologies deliver comprehensive insights into fungal biology, paving the way for novel therapeutic and vaccine targets. While these approaches hold immense promise, challenges such as cost, accessibility, and translational barriers remain. A coordinated effort among researchers, clinicians, and policymakers is critical to advancing these strategies and addressing the global burden of fungal infections effectively.
published_date 2025-02-01T08:31:07Z
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