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Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches

Giorgia Vaccaro Orcid Logo, Jacqueline L. Stair, Stewart B. Kirton, Daniel Baker, Amira Guirguis Orcid Logo

Drug Testing and Analysis

Swansea University Author: Amira Guirguis Orcid Logo

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DOI (Published version): 10.1002/dta.3864

Abstract

Infusing synthetic cannabinoid receptor agonists on paper quickly became a main route for illicit entry into prisons (i.e., mail correspondence) in the last decade. So far, there are limited data on validated detection methods and typical concentration profiles of these substances on paper to inform...

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Published in: Drug Testing and Analysis
ISSN: 1942-7603 1942-7611
Published: UK Wiley 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa68732
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spelling 2025-02-26T13:08:51.7908043 v2 68732 2025-01-24 Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches b49270b9a0d580cf4f31f9a1b6c93f87 0000-0001-8255-0660 Amira Guirguis Amira Guirguis true false 2025-01-24 MEDS Infusing synthetic cannabinoid receptor agonists on paper quickly became a main route for illicit entry into prisons (i.e., mail correspondence) in the last decade. So far, there are limited data on validated detection methods and typical concentration profiles of these substances on paper to inform interventions. An approach to quantify and map the synthetic cannabinoid receptor agonist (SCRA) 5F-MDMB-PINACA on a seized paper sample from a UK Prison was determined using ultraperformance liquid chromatography–mass spectrometry. The seized paper sample was initially screened using ultraperformance liquid chromatography–quadrupole time-of-flight–mass spectrometry that confirmed the presence of 5F-MDMB-PINACA. A quantification method was then optimised and validated for the SCRA using a simple liquid chromatography–quadrupole Dalton–mass spectrometry system. Percentage recovery studies were carried out on paper spiked with 1, 5 and 20 mg/cm2 of 5F-MDMB-PINACA with five consecutive MeOH extractions. Results showed that one extraction recovered 83%–86%, while three extractions resulted in 98%–99% 5F-MDMB-PINACA recovery. Finally, the method was used to determine the concentration profile across the seized paper sample; 5F-MDMB-PINACA was in detectable amounts on all the paper subunits (n = 39) ranging between 0.26 and 55.13 μg/cm2, displaying a wide distribution of concentrations. Concentration profiles of SCRAs on seized paper samples are informative for interventions for those who are abusing or handling these substances in custodial settings but also provide key concentration ranges for those developing advanced methods of analysis in this area. Journal Article Drug Testing and Analysis 0 Wiley UK 1942-7603 1942-7611 5F-MDMB-PINACA; HPLC-MS; new psychoactive substances; prison; synthetic cannabinoids 7 2 2025 2025-02-07 10.1002/dta.3864 Short Communication COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2025-02-26T13:08:51.7908043 2025-01-24T09:02:33.6651653 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy Giorgia Vaccaro 0000-0002-2895-4952 1 Jacqueline L. Stair 2 Stewart B. Kirton 3 Daniel Baker 4 Amira Guirguis 0000-0001-8255-0660 5 68732__33683__5e98cbaa34ac4a7f9ace888decc18c56.pdf 68732.VoR.pdf 2025-02-26T12:17:13.6992562 Output 818690 application/pdf Version of Record true © 2025 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/
title Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches
spellingShingle Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches
Amira Guirguis
title_short Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches
title_full Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches
title_fullStr Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches
title_full_unstemmed Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches
title_sort Screening and Quantification of the Synthetic Cannabinoid Receptor Agonist 5F‐MDMB‐PINACA From Seized Prison Paper Using Ultraperformance Liquid Chromatography–Mass Spectrometry Approaches
author_id_str_mv b49270b9a0d580cf4f31f9a1b6c93f87
author_id_fullname_str_mv b49270b9a0d580cf4f31f9a1b6c93f87_***_Amira Guirguis
author Amira Guirguis
author2 Giorgia Vaccaro
Jacqueline L. Stair
Stewart B. Kirton
Daniel Baker
Amira Guirguis
format Journal article
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publishDate 2025
institution Swansea University
issn 1942-7603
1942-7611
doi_str_mv 10.1002/dta.3864
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
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description Infusing synthetic cannabinoid receptor agonists on paper quickly became a main route for illicit entry into prisons (i.e., mail correspondence) in the last decade. So far, there are limited data on validated detection methods and typical concentration profiles of these substances on paper to inform interventions. An approach to quantify and map the synthetic cannabinoid receptor agonist (SCRA) 5F-MDMB-PINACA on a seized paper sample from a UK Prison was determined using ultraperformance liquid chromatography–mass spectrometry. The seized paper sample was initially screened using ultraperformance liquid chromatography–quadrupole time-of-flight–mass spectrometry that confirmed the presence of 5F-MDMB-PINACA. A quantification method was then optimised and validated for the SCRA using a simple liquid chromatography–quadrupole Dalton–mass spectrometry system. Percentage recovery studies were carried out on paper spiked with 1, 5 and 20 mg/cm2 of 5F-MDMB-PINACA with five consecutive MeOH extractions. Results showed that one extraction recovered 83%–86%, while three extractions resulted in 98%–99% 5F-MDMB-PINACA recovery. Finally, the method was used to determine the concentration profile across the seized paper sample; 5F-MDMB-PINACA was in detectable amounts on all the paper subunits (n = 39) ranging between 0.26 and 55.13 μg/cm2, displaying a wide distribution of concentrations. Concentration profiles of SCRAs on seized paper samples are informative for interventions for those who are abusing or handling these substances in custodial settings but also provide key concentration ranges for those developing advanced methods of analysis in this area.
published_date 2025-02-07T11:25:22Z
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