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Carotid Intima‐Media Thickness, Carotid Distensibility, and Incident Heart Failure in Older Men: The British Regional Heart Study
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A. Olia Papacosta ,
Lucy T. Lennon ,
Libby Ellins ,
Julian Halcox ,
Peter H Whincup ,
S. Goya Wannamethee
Journal of the American Heart Association
Swansea University Authors:
Libby Ellins , Julian Halcox
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© 2025 The Author(s). Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License (CC BY).
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DOI (Published version): 10.1161/jaha.124.037167
Abstract
Background: Carotid intima‐media thickness (CIMT) and carotid distensibility are markers of arterial change; however, little is known of the association with incident heart failure (HF). We aimed to assess this. Methods: This was a longitudinal analysis of data from the British Regional Heart Study,...
| Published in: | Journal of the American Heart Association |
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| ISSN: | 2047-9980 |
| Published: |
Wiley
2025
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa68666 |
| Abstract: |
Background: Carotid intima‐media thickness (CIMT) and carotid distensibility are markers of arterial change; however, little is known of the association with incident heart failure (HF). We aimed to assess this. Methods: This was a longitudinal analysis of data from the British Regional Heart Study, a prospective cohort study. A total of 1631 men aged 71 to 92 years, without a diagnosis of HF at baseline, were included. Between 2010 and 2012, participants completed a questionnaire, underwent a physical examination, and provided a fasting blood sample. CIMT and carotid artery distension were measured, and carotid distensibility was calculated. Cox proportional hazards modeling was used to assess the multivariate‐adjusted hazard ratios (HRs) of incident HF by quartiles of CIMT and distensibility, excluding men with prevalent myocardial infarction. Results: The values used in the analysis were adjusted for age, social class, smoking, physical activity, alcohol status, body mass index, use of statins and antihypertensives, prevalent diabetes and stroke, pulse pressure, and presence of atrial arrhythmias. Lower carotid distensibility (bottom quartile) and higher CIMT (top quartile) were associated with increased risk of incident HF (HR, 2.55 [95% CI, 1.24–5.24]; P=0.01; and HR, 2.20 [95% CI, 1.14–4.23]; P=0.02, respectively). CIMT but not carotid distensibility was associated with incident myocardial infarction. The association between carotid distensibility and incident HF persisted after adjustment for incident myocardial infarction and CIMT (HR, 2.53 [95% CI, 1.23–5.22]; P=0.01); however, the association between CIMT and incident HF was attenuated after this adjustment (HR, 1.64 [95% CI, 0.84–3.21]; P=0.15). Conclusions: Lower carotid distensibility and higher CIMT were associated with an increased risk of incident HF, despite adjustment for incident myocardial infarction. |
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| Keywords: |
cardiovascular diseases, carotid artery distensibility, carotid intima‐media thickness, heart failure |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This work was supported by the British Heart Foundation (Grant Nos. RG/19/4/34452 and PG/09/024/26857). A. A. is an Academic Clinical Fellow (Award ID: ACF‐2020‐18‐012), funded by The National Institute for Health and Care Research, UK. The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health and Care Research, or the Department of Health and Social Care. The funders had no role in the design and conduct of the study; collection, management, analysis, interpretation of the data; or preparation, review, approval of, or decision to publish the manuscript. |