Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment

Siervo, Mario; Johnston, Fionnuala; Calton, Emily; James, Anthony; M, Blossom C; Hornsby, Amanda; Davies, Jeffrey; Burn, David

doi:10.1016/j.clnesp.2024.10.167

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Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment

Mario Siervo, Fionnuala Johnston, Emily Calton, Anthony James, Blossom C M Stephan, Amanda Hornsby, Jeffrey Davies

, David Burn

Clinical Nutrition ESPEN, Volume: 64, Pages: 425 - 434

Swansea University Authors: Amanda Hornsby, Jeffrey Davies

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DOI (Published version): 10.1016/j.clnesp.2024.10.167

Abstract

Appetite dysregulation in Parkinson's Disease (PD) appears to be linked to physical and cognitive deterioration. PD patients with and without cognitive impairment (CI) were compared to an age-matched control group to explore predictors of appetite control in fasting and post-prandial conditions...

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Published in:	Clinical Nutrition ESPEN
ISSN:	2405-4577
Published:	Elsevier BV 2024
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa68584

first_indexed	2025-01-09T20:33:53Z
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spelling	2024-12-17T15:20:57.8844561 v2 68584 2024-12-17 Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment 52a586048b9cb0543fe0f3e112e345c3 Amanda Hornsby Amanda Hornsby true false 2cb3d1d96a7870a84d2f758e865172e6 0000-0002-4234-0033 Jeffrey Davies Jeffrey Davies true false 2024-12-17 Appetite dysregulation in Parkinson's Disease (PD) appears to be linked to physical and cognitive deterioration. PD patients with and without cognitive impairment (CI) were compared to an age-matched control group to explore predictors of appetite control in fasting and post-prandial conditions. Fifty-five patients were recruited and divided into three groups: twenty controls (age: 74 y, BMI: 25.8 kg/m ), nineteen PD patients without CI (72.5 y, 25.1 kg/m ) and sixteen PD patients with CI (74.3 y, 24.0 kg/m ). Self-reported appetite perception and circulating blood metabolic biomarkers were measured in fasting and over a 3-h post-prandial period. Biomarkers included glucose, insulin, tumour necrosis factor alpha (TNF-α), leptin, acyl-ghrelin, total ghrelin, peptide YY (PYY), glucagon like peptide 1 (GLP-1), insulin growth factor 1 (IGF-1), growth factor (GF) and triglycerides. Patients were then provided with a mixed meal to eat ad libitum with the aim to evaluate links between metabolic biomarkers and control of energy intake. PD patients with CI had a significant lower protein intake (7.4 ± 2.5 g, p = 0.01) compared to controls (21.9 ± 3.1 g) and PD patients without CI (14.3 ± 3.0 g). Post-prandial plasma GLP-1 concentrations were associated with decreased hunger perception (B±SE, -5.3 ± 2.4 mm·h , p = 0.04). PYY concentrations were significantly associated with GLP-1 in fasting (r = 0.40, p = 0.005) and post-prandial (r = 0.46, p < 0.001) conditions. In a multivariate model, post-prandial PYY concentrations were a significant predictor of ad libitum energy intake in all subjects (B±SE, -87.5 ± 34.9 kcal, p = 0.01) and in patients with PD (B±SE, -106.8 ± 44.9 kcal, p = 0.04). PYY and GLP-1 appeared to influence appetite control in PD patients and their roles merit further investigation. Journal Article Clinical Nutrition ESPEN 64 425 434 Elsevier BV 2405-4577 Parkinson disease; Cognitive function; Energy intake; Biomarkers; GLP-1; PYY 1 12 2024 2024-12-01 10.1016/j.clnesp.2024.10.167 COLLEGE NANME COLLEGE CODE Swansea University Another institution paid the OA fee This study was funded by Newcastle NIHR Biomedical Research Unit. 2024-12-17T15:20:57.8844561 2024-12-17T15:13:34.1545337 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Mario Siervo 1 Fionnuala Johnston 2 Emily Calton 3 Anthony James 4 Blossom C M Stephan 5 Amanda Hornsby 6 Jeffrey Davies 0000-0002-4234-0033 7 David Burn 8
title	Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment
spellingShingle	Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment Amanda Hornsby Jeffrey Davies
title_short	Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment
title_full	Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment
title_fullStr	Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment
title_full_unstemmed	Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment
title_sort	Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment
author_id_str_mv	52a586048b9cb0543fe0f3e112e345c3 2cb3d1d96a7870a84d2f758e865172e6
author_id_fullname_str_mv	52a586048b9cb0543fe0f3e112e345c3_*_Amanda Hornsby 2cb3d1d96a7870a84d2f758e865172e6_*_Jeffrey Davies
author	Amanda Hornsby Jeffrey Davies
author2	Mario Siervo Fionnuala Johnston Emily Calton Anthony James Blossom C M Stephan Amanda Hornsby Jeffrey Davies David Burn
format	Journal article
container_title	Clinical Nutrition ESPEN
container_volume	64
container_start_page	425
publishDate	2024
institution	Swansea University
issn	2405-4577
doi_str_mv	10.1016/j.clnesp.2024.10.167
publisher	Elsevier BV
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
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description	Appetite dysregulation in Parkinson's Disease (PD) appears to be linked to physical and cognitive deterioration. PD patients with and without cognitive impairment (CI) were compared to an age-matched control group to explore predictors of appetite control in fasting and post-prandial conditions. Fifty-five patients were recruited and divided into three groups: twenty controls (age: 74 y, BMI: 25.8 kg/m ), nineteen PD patients without CI (72.5 y, 25.1 kg/m ) and sixteen PD patients with CI (74.3 y, 24.0 kg/m ). Self-reported appetite perception and circulating blood metabolic biomarkers were measured in fasting and over a 3-h post-prandial period. Biomarkers included glucose, insulin, tumour necrosis factor alpha (TNF-α), leptin, acyl-ghrelin, total ghrelin, peptide YY (PYY), glucagon like peptide 1 (GLP-1), insulin growth factor 1 (IGF-1), growth factor (GF) and triglycerides. Patients were then provided with a mixed meal to eat ad libitum with the aim to evaluate links between metabolic biomarkers and control of energy intake. PD patients with CI had a significant lower protein intake (7.4 ± 2.5 g, p = 0.01) compared to controls (21.9 ± 3.1 g) and PD patients without CI (14.3 ± 3.0 g). Post-prandial plasma GLP-1 concentrations were associated with decreased hunger perception (B±SE, -5.3 ± 2.4 mm·h , p = 0.04). PYY concentrations were significantly associated with GLP-1 in fasting (r = 0.40, p = 0.005) and post-prandial (r = 0.46, p < 0.001) conditions. In a multivariate model, post-prandial PYY concentrations were a significant predictor of ad libitum energy intake in all subjects (B±SE, -87.5 ± 34.9 kcal, p = 0.01) and in patients with PD (B±SE, -106.8 ± 44.9 kcal, p = 0.04). PYY and GLP-1 appeared to influence appetite control in PD patients and their roles merit further investigation.
published_date	2024-12-01T20:36:55Z
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score	11.04748

Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment

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