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MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Eva C. Sonnenschein Orcid Logo, Mitja M Zdouc, Kai Blin Orcid Logo, Nico L L Louwen, Jorge Navarro Orcid Logo, Catarina Loureiro Orcid Logo, Chantal D Bader, Constance B Bailey, Lena Barra, Thomas J Booth, Kenan A J Bozhüyük, José D D Cediel-Becerra, Zachary Charlop-Powers, Marc G Chevrette, Yit Heng Chooi, Paul M D’Agostino, Tristan de Rond, Elena Del Pup, Katherine R Duncan, Wenjia Gu, Novriyandi Hanif, Eric J N Helfrich, Matthew Jenner, Yohei Katsuyama, Aleksandra Korenskaia, Daniel Krug, Vincent Libis, George A Lund, Shrikant Mantri, Kalindi D Morgan, Charlotte Owen, Chin-Soon Phan, Benjamin Philmus, Zachary L Reitz, Serina L Robinson, Kumar Saurabh Singh, Robin Teufel, Yaojun Tong, Fidele Tugizimana, Dana Ulanova, Jaclyn M Winter, César Aguilar, Daniel Y Akiyama, Suhad A A Al-Salihi, Mohammad Alanjary, Fabrizio Alberti, Gajender Aleti, Shumukh A Alharthi, Mariela Y Arias Rojo, Amr A Arishi, Hannah E Augustijn, Nicole E Avalon, J Abraham Avelar-Rivas, Kyle K Axt, Hellen B Barbieri, Julio Cesar J Barbosa, Lucas Gabriel Barboza Segato, Susanna E Barrett, Martin Baunach, Christine Beemelmanns, Dardan Beqaj, Tim Berger, Jordan Bernaldo-Agüero, Sandra M Bettenbühl, Vincent A Bielinski, Friederike Biermann, Ricardo M Borges, Rainer Borriss, Milena Breitenbach, Kevin M Bretscher, Michael W Brigham, Larissa Buedenbender, Brodie W Bulcock, Carolina Cano-Prieto, João Capela, Victor J Carrion, Riley S Carter, Raquel Castelo-Branco, Gabriel Castro-Falcón, Fernanda O Chagas, Esteban Charria-Girón, Ayesha Ahmed Chaudhri, Vasvi Chaudhry, Hyukjae Choi, Yukyung Choi, Roya Choupannejad, Jakub Chromy, Melinda S Chue Donahey Orcid Logo, Jérôme Collemare, Jack A Connolly, Kaitlin E Creamer, Max Crüsemann, Andres Arredondo Cruz, Andres Cumsille, Jean-Felix Dallery, Luis Caleb Damas-Ramos, Tito Damiani, Martinus de Kruijff, Belén Delgado Martín, Gerardo Della Sala, Jelle Dillen, Drew T Doering, Shravan R Dommaraju, Suhan Durusu, Susan Egbert, Mark Ellerhorst, Baptiste Faussurier, Artem Fetter, Marc Feuermann, David P Fewer, Jonathan Foldi, Andri Frediansyah, Erin A Garza, Athina Gavriilidou, Andrea Gentile, Jennifer Gerke, Hans Gerstmans, Juan Pablo Gomez-Escribano, Luz A González-Salazar, Natalie E Grayson, Claudio Greco, Juan E Gris Gomez, Sebastian Guerra, Shaday Guerrero Flores, Alexey Gurevich, Karina Gutiérrez-García, Lauren Hart, Kristina Haslinger, Beibei He, Teo Hebra, Jethro L Hemmann, Hindra Hindra, Lars Höing, Darren C Holland, Jonathan E Holme, Therese Horch, Pavlo Hrab, Jie Hu, Thanh-Hau Huynh, Ji-Yeon Hwang, Riccardo Iacovelli, Dumitrita Iftime, Marianna Iorio, Sidharth Jayachandran, Eunah Jeong, Jiayi Jing, Jung J Jung, Yuya Kakumu, Edward Kalkreuter, Kyo Bin Kang, Sangwook Kang, Wonyong Kim, Geum Jin Kim, Hyunwoo Kim, Hyun Uk Kim, Martin Klapper, Robert A Koetsier, Cassandra Kollten, Ákos T Kovács, Yelyzaveta Kriukova, Noel Kubach, Aditya M Kunjapur, Aleksandra K Kushnareva, Andreja Kust, Jessica Lamber, Martin Larralde, Niels J Larsen, Adrien P Launay, Ngoc-Thao-Hien Le, Sarah Lebeer, Byung Tae Lee, Kyungha Lee, Katherine L Lev, Shu-Ming Li, Yong-Xin Li, Cuauhtémoc Licona-Cassani, Annette Lien, Jing Liu, Julius Adam V Lopez, Nataliia V Machushynets, Marla I Macias, Taifo Mahmud, Matiss Maleckis, Añadir Maharai Martinez-Martinez, Yvonne Mast, Marina F Maximo, Christina M McBride, Rose M McLellan, Khyati Mehta Bhatt, Chrats Melkonian, Aske Merrild, Mikko Metsä-Ketelä, Douglas A Mitchell, Alison V Müller, Giang-Son Nguyen, Hera T Nguyen, Timo H J Niedermeyer, Julia H O’Hare, Adam Ossowicki, Bohdan O Ostash, Hiroshi Otani, Leo Padva, Sunaina Paliyal, Xinya Pan, Mohit Panghal, Dana S Parade, Jiyoon Park, Jonathan Parra, Marcos Pedraza Rubio, Huong T Pham, Sacha J Pidot, Jörn Piel, Bita Pourmohsenin, Malik Rakhmanov, Sangeetha Ramesh, Michelle H Rasmussen, Adriana Rego, Raphael Reher, Andrew J Rice, Augustin Rigolet, Adriana Romero-Otero, Luis Rodrigo Rosas-Becerra, Pablo Y Rosiles, Adriano Rutz, Byeol Ryu, Libby-Ann Sahadeo, Murrel Saldanha, Luca Salvi, Eduardo Sánchez-Carvajal, Christian Santos-Medellin, Nicolau Sbaraini, Sydney M Schoellhorn, Clemens Schumm, Ludek Sehnal, Nelly Selem, Anjali D Shah, Tania K Shishido, Simon Sieber, Velina Silviani, Garima Singh, Hemant Singh, Nika Sokolova, Eva C Sonnenschein, Margherita Sosio, Sven T Sowa, Karin Steffen, Evi Stegmann, Alena B Streiff, Alena Strüder, Frank Surup, Tiziana Svenningsen, Douglas Sweeney, Judit Szenei, Azat Tagirdzhanov, Bin Tan, Matthew J Tarnowski, Barbara R Terlouw, Thomas Rey, Nicola U Thome, Laura Rosina Torres Ortega, Thomas Tørring, Marla Trindade, Andrew W Truman, Marie Tvilum, Daniel W Udwary, Christoph Ulbricht, Lisa Vader, Gilles P van Wezel, Max Walmsley, Randika Warnasinghe, Heiner G Weddeling, Angus N M Weir, Katherine Williams, Sam E Williams, Thomas E Witte, Steffaney M Wood Rocca, Keith Yamada, Dong Yang, Dongsoo Yang, Jingwei Yu, Zhenyi Zhou, Nadine Ziemert, Lukas Zimmer, Alina Zimmermann, Christian Zimmermann, Justin J J van der Hooft Orcid Logo, Roger G Linington Orcid Logo, Tilmann Weber Orcid Logo, Marnix H Medema Orcid Logo, Shumukh Alharthi, Claudio Greco Orcid Logo

Nucleic Acids Research, Volume: 53, Issue: D1, Pages: D678 - D690

Swansea University Authors: Eva C. Sonnenschein Orcid Logo, Shumukh Alharthi, Claudio Greco Orcid Logo

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DOI (Published version): 10.1093/nar/gkae1115

Abstract

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes...

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Published in: Nucleic Acids Research
ISSN: 0305-1048 1362-4962
Published: Oxford University Press (OUP) 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa68571
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2025-01-30T13:36:12.6399744</datestamp><bib-version>v2</bib-version><id>68571</id><entry>2024-12-16</entry><title>MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration</title><swanseaauthors><author><sid>f6a4027578a15ea3e6453a54b849c686</sid><ORCID>0000-0001-6959-5100</ORCID><firstname>Eva C.</firstname><surname>Sonnenschein</surname><name>Eva C. Sonnenschein</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>78d65007643ec30405caaf9df99c06e8</sid><firstname>Shumukh</firstname><surname>Alharthi</surname><name>Shumukh Alharthi</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>cacac6459bd7cf4a241f63661006036f</sid><ORCID>0000-0003-3067-0999</ORCID><firstname>Claudio</firstname><surname>Greco</surname><name>Claudio Greco</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-12-16</date><deptcode>BGPS</deptcode><abstract>Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.</abstract><type>Journal Article</type><journal>Nucleic Acids Research</journal><volume>53</volume><journalNumber>D1</journalNumber><paginationStart>D678</paginationStart><paginationEnd>D690</paginationEnd><publisher>Oxford University Press (OUP)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0305-1048</issnPrint><issnElectronic>1362-4962</issnElectronic><keywords/><publishedDay>6</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2025</publishedYear><publishedDate>2025-01-06</publishedDate><doi>10.1093/nar/gkae1115</doi><url/><notes/><college>COLLEGE NANME</college><department>Biosciences Geography and Physics School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BGPS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>M.M.Z. was supported by the NWO Grant KICH1.LWV04.21.013 and by the Horizon 2020 Grant 101000392; C.L. was supported by the NWO Open Science Project 'BiG-CODEC' No. OSF.23.1.044; C.D.B was supported by the German Research Foundation Grant No. 547394769; C.B.B. was supported by the University of Sydney Drug Discovery Initiative; T.J.B was supported by the Novo Nodisk Foundation Grant NNF22OC0078997; Y.H.C. was supported by the Australian Research Council Industry Fellowship IM230100154; P.M.D. was supported by the Hans Fischer Society; K.R.D. was supported by the UK Government Department for Environment, Food &amp; Rural Affairs (DEFRA) Global Centre on Biodiversity for the Climate and by the United Kingdom Research and Innovation (EP/X03142X/1) and by the Horizon Europe Marie Sk&#x142;odowska-Curie grant agreement No 101072485; N.H. was supported by the Indonesia Endowment Fund for Education Agency (LPDP) and National Research and Innovation Agency (BRIN) of the Republic of Indonesia (106/IV/KS/11/2023 and 41644/IT3/PT.01.03/P/B/2023) and by the the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia (027/E5/PG.02.00.PL/2024); M.J. was supported by the UKRI Future Leaders Fellowship (MR/W011247/1); A.Korenskaia was supported by the Horizon Europe Marie Sk&#x142;odowska-Curie grant agreement No 101072485; V.L. was supported by the ERC Starting Grant 101117891-MeDiSyn and by the Agence Nationale de la Recherche project ANR-22-CE44-0011-01 UMISYN; G.A.L. was supported by the Growing Health Institute Strategic Programme (BB/X010953/1; BBS/E/RH/230003B); S.M. was supported by the Department of Biotechnology (DBT), Government of India and by the National Agri-Food Biotechnology Institute (NABI); C-S.P. was supported by the EU project No. 101087181 (Natural Products Research at Latvian Institute of Organic Synthesis as a Driver for Excellence in Innovation); R.T. was supported by the Swiss National Science Foundation (SNSF), grant 212747; Y.T. was supported by the National Key Research and Development Program of China (2021YFA0909500) and by the the National Natural Science Foundation of China (32170080 and 32370026) and by the Shanghai Pilot Program for Basic Research - Shanghai Jiao Tong University; D.U. was supported by the Japan Society for Promotion of Science KAKENHI grant number 21K06336; D.Y.A. was supported by the S&#xE3;o Paulo Research Foundation (FAPESP) research scholarship (grant 21/07038-0); M.A. was supported by the NWO Talent programme Veni science domain (VI.Veni.202.130); F.A. was supported by the UKRI Future Leaders Fellowship (MR/V022334/1); G.A. was supported by the USDA Evans-Allen Research Grant (222676); N.E.A. was supported by the National Center for Complementary and Integrative Health of the NIH under award number F32AT011475; H.B.B. was supported by the S&#xE3;o Paulo Research Foundation (FAPESP) research scholarship (grant 21/08947-3); S.E.B. was supported by the National Science Foundation Graduate Research Fellowship (DGE 21-46756) and by the the University of Illinois Urbana-Champaign Illinois Distinguished Fellowship; C.B. was supported by the European Union Horizon 2020 research and innovation program (ERC Grant number: 802736, MORPHEUS); J.B-A. was supported by the Consejo Nacional de Ciencia y Tecnolog&#xED;a (CONACyT) [735867]; K.M.B. was supported by the NWO Merian fund (Micro-GRICE); M.W.B. was supported by the United Kingdom Research and Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC) funded White Rose Mechanistic and Structural Biology Doctoral Training Program (BB/T007222/1); L.B. was supported by the Horizon Europe Marie Sk&#x142;odowska-Curie Actions Postdoctoral Fellowship funded by the European Union (Project chelOMICS - grant agreement No. 101066127); V.J.C. was supported by the Ministerio de Ciencia, Innovaci&#xF3;n y Universidades project RYC2020-029240-I; R.C-B. was supported by the scholarship SFRH/BD/136367/2018 by Funda&#xE7;ao para a Ciencia e Tecnologia (FCT); G.C-F. was supported by the National Institutes of Health (NIH)/NIGMS K12 GM068524 Award as a San Diego IRACDA Scholar.; E.C-G. was supported by the HZI POF IV Cooperativity and Creativity Project Call; V.C. was supported by the Alexander von Humboldt-Stiftung (Ref: 3.5-IND-1199743-HFST-P) and by the Cluster of Excellence: Controlling Microbes to Fight Infection (CMFI-YIG (EXC-2124/1-09.029_0; H.C. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1A6A1A03044512, and NRF-2021R1A2C1010727); Y.C. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1C1C1004046 and NRF-2022R1A5A2021216); J.A.C. was supported by the Signals in the Soil program via UK Research and Innovation (UKRI; NE/T010959/1); K.E.C. was supported by the Chan Zuckerberg Initiative Foundation grant number CZIF2022-007203; M.C. was supported by the German Research Foundation (DFG) Grant No. 495740318; J-F.D. was supported by the Agence Nationale de la Recherche (ShySM grant ANR-24-CE20-7299-01 and by the EUR Saclay Plant Sciences-SPS (ANR-17-EUR-0007); L.C.D-R. was supported by the European Union's Horizon Europe programme under the Marie Sk&#x142;odowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); T.D. was supported by the European Regional Development Fund, Programme Johannes Amos Comenius project &#x2018;IOCB MSCA PF Mobility&#x2019; no. CZ.02.01.01/00/22_010/0002733; M.dK. was supported by the European Union's Horizon 2020 research and innovation program (ERC Grant number: 802736, MORPHEUS).; A.Fetter was supported by the United Kingdom Research and Innovation (EP/X03142X/1) and by the Horizon Europe Marie Sk&#x142;odowska-Curie grant agreement No 101072485; M.F. was supported by the Swiss Federal Government through the State Secretariat for Education, Research and Innovation SERI; A.Frediansyah was supported by the Fulbright Grant (PS00349981); A.Gavriilidou was supported by the Deutsche Forschungsgemeinschaft [398967434-TRR 261]; A.Gentile was supported by the Italian Ministry of Research (Grant DM60066); H.G. was supported by the Research Foundation&#x2013;Flanders (FWO) under the scope of junior postdoctoral fellowship (1229222N); L.A.G-S. was supported by the CONAHCYT scholarship (#971765); N.E.G. was supported by the NIGMS R01-GM146224, NERRS NA22NOS4200050; C.G. was supported by the BBSRC (BB/V005723/2); J.E.G.G. was supported by the CONAHCYT scholarship (#1347411); S.G. was supported by the National Institutes of Health (NIH), Grant T32GM136583. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.; L.H. was supported by the NIH F31 1F31ES036421-01; T.Hebra was supported by the European Union's Horizon Europe research and innovation program under the Marie Sk&#x142;odowska-Curie grant agreement No. 101130799; T.Horch was supported by the Novo Nordisk Foundation grant-number: CFB 2.0, NNF20CC0035580; M.I. was supported by the Italian Ministry of Research (Grant DM60066); E.J. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1C1C1004046 and NRF-2022R1A5A2021216); K.B.K. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1C1C1004046 and NRF-2022R1A5A2021216); S.K. was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-RS-2024-00408499) and by the National Research Foundation of Korea grants funded by the Republic of Korean Government (Ministry of Science and ICT) (NRF-RS-2024-00352229); W.K. was supported by the National Research Foundation of Korea grant funded by the Korea government (No. 2022R1C1C2004118); G.J.K. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1A6A1A03044512, and NRF-2021R1A2C1010727); H.K. was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIT) Grants NRF 2018R1A5A2023127 and RS-2023-00211868; M.K. was supported by the Werner Siemens Foundation grant Paleobiotechnology; R.A.K. was supported by the NWO-XL (OCENW.XL21.XL21.088); A.T.K. was supported by the Danish National Research Foundation CeMiSt, DNRF137 and by the Novo Nordisk Foundation INTERACT, NNF19SA0059360; A.M.K. was supported by the U.S. National Science Foundation (CBET-2032243); A.Kust was supported by the Delta Stewardship Council Delta Science Program; S.L. was supported by the European Research Council under European Union's Horizon 2020 Research and Innovation Program ERC St grant 852600 Lacto-Be; S-M.L. was supported by the Deutsche Forschungsgemeinschaft LI844/11-1 and LI844/14-1; A.L. was supported by the European Union's Horizon Europe programme under the Marie Sk&#x142;odowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); M.I.M. was supported by the Conahcyt Mexico International PhD Studentship and by the Strathclyde University Global Research Scholarship; M.M. was supported by the Novo Nordisk Foundation (Grant NNF23OC0082881) and Innovation Fund Denmark (Grant 3141-00013A); Y.M. was supported by the Leibniz Association grant K445/2022; M.F.M. was supported by the S&#xE3;o Paulo Research Foundation (FAPESP) research scholarship (grant 23/01956-2); C.M.M. was supported by the NSF GRFP (#DGE 2241144); C.M. was supported by the MiCRop Consortium (NWO/OCW grant no. 024.004.014); A.M. was supported by the Carlsberg Foundation (CF22-1239); G-S.N. was supported by the SINTEF internal projects, POP-SEP BiocatDB (102022750), SEP AGREE (102029187) and POS BIOINFO 2024 (102024676-14), European Union's Horizon 2020 research and innovation programme under Grant Agreement no. 101000392 (MARBLES), no. 101081957 (BLUETOOLS), and no. 862923 (AtlantECO); A.O. was supported by the Marie Sklodowska-Curie grant No. 101106349; B.O.O. was supported by the BG-21F, Ministry of Education and Science of Ukraine and by the 57/0009, National Research Fund of Ukraine (partial support); H.O. was supported by the Office of Science of the U.S. Department of Energy operated under Contract No. DE-AC02-05CH11231; L.P. was supported by the German Academic Scholarship Foundation; X.P. was supported by the NWO-XL grant OCENW.GROOT.2019.063; M.P. was supported by the Department of Biotechnology (DBT), Government of India and by the University Grants Commission (UGC), Ministry of Education, Government of India; M.P.R. was supported by the Spanish &#x201C;Junta de Andaluc&#xED;a&#x201D; project PROYEXCEL_00012; H.T.P. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1C1C1004046 and NRF-2022R1A5A2021216); S.J.P. was supported by the National Health and Medical Research Council GNT2021638, Australian Research Council Discovery Project DP230102668; B.P. was supported by the SECRETed EU Project Horizon 2020 (101000794); M.H.R. was supported by the European Research Council (ERC), European Union's Horizon 2020 Research and Innovation Program (grant agreement no. 865738); A.J.R. was supported by the Chemical-Biology Interface Training Grant (Grant T32-GM136629) and a National Science Foundation Graduate Research Fellowship (Grant DGE 21-46756); A.R. was supported by the ERC Advanced Grant 101055020-COMMUNITY; L.R.R-B. was supported by the Consejo Nacional de Ciencia y Tecnolog&#xED;a (CONACyT) [757173]; L.Salvi was supported by the European Union's Horizon Europe programme under the Marie Sk&#x142;odowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); E.S-C. was supported by the PhD scholarships ANID N&#xB0; 21231991; L.Sehnal was supported by the Horizon Europe Marie Sk&#x142;odowska-Curie Actions Postdoctoral Fellowship funded by the European Union (Project NAfrAM - grant agreement No. 10106428); A.D.S. was supported by the Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership [BB/T008741/1]; T.K.S. was supported by the Novo Nordisk Foundation (Grant number: NNF22OC0080109); V.S. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1A6A1A03044512, and NRF-2021R1A2C1010727); E.C.S. was supported by the Pathfinder Open 2022, a European Innovation Council (EIC) work programme that is part of Horizon Europe (grant agreement no. 101099528) and UK Innovation Funding Agency (UKRI) (reference no. 10062709).; M.S. was supported by the Italian Ministry of Research (Grant DM60066); K.S. was supported by the Swedish Pharmaceutical Society PostDoc stipend; A.B.S. was supported by the Swiss National Science Foundation (SNSF, 205320_219638); T.S. was supported by the Carlsberg Foundation (CF22-1239); J.S. was supported by the European Union's Horizon Europe programme under the Marie Sk&#x142;odowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); A.T. was supported by the Saarland University through the NextAID project; M.J.T. was supported by the Pathfinder Open 2022, a European Innovation Council (EIC) work programme that is part of Horizon Europe (grant agreement no. 101099528) and UK Innovation Funding Agency (UKRI) (reference no. 10062709).; T.T. was supported by the Carlsberg Foundation (CF22-1239); A.W.T. was supported by the BBSRC Institute Strategic Program grant (BB/X01097X/1); M.T. was supported by the AUFF (AUFF-E-2022-9-42); L.V. was supported by the European Union's Horizon Europe programme under the Marie Sk&#x142;odowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); G.P.vW. was supported by the ERC Advanced Grant 101055020-COMMUNITY; K.W. was supported by the MR/N029909/1, Medical Research Council, UK; S.E.W. was supported by the Novo Nordisk Foundation Postdoctoral Fellowship (NNF22OC0079021); T.E.W. was supported by the Natural Science and Research Council of Canada PGS-D scholarship; D.Y. was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Grant RS-2024-00440975); A.Z. was supported by the German Center for Infection Research (DZIF) (TTU 09.826); C.Z. was supported by the Austrian Science Fund (FWF) [10.55776/P 34036]; R.G.L. was supported by the Natural Sciences and Engineering Research Council of Canada Discovery Grant program; T.W. was supported by the Novo Nordisk Foundation, NNF20CC0035580 and by the Danish National Research Foundation CeMiSt, DNRF137 and by the European Union's Horizon Europe programme under the Marie Sk&#x142;odowska-Curie grant agreement No 101072485 (MAGic-MOLFUN).</funders><projectreference/><lastEdited>2025-01-30T13:36:12.6399744</lastEdited><Created>2024-12-16T06:32:21.4723931</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Biosciences, Geography and Physics - Biosciences</level></path><authors><author><firstname>Eva C.</firstname><surname>Sonnenschein</surname><orcid>0000-0001-6959-5100</orcid><order>1</order></author><author><firstname>Mitja&#xA0;M</firstname><surname>Zdouc</surname><order>2</order></author><author><firstname>Kai</firstname><surname>Blin</surname><orcid>0000-0003-3764-6051</orcid><order>3</order></author><author><firstname>Nico&#xA0;L L</firstname><surname>Louwen</surname><order>4</order></author><author><firstname>Jorge</firstname><surname>Navarro</surname><orcid>0000-0003-2992-1607</orcid><order>5</order></author><author><firstname>Catarina</firstname><surname>Loureiro</surname><orcid>0000-0002-6258-2080</orcid><order>6</order></author><author><firstname>Chantal&#xA0;D</firstname><surname>Bader</surname><order>7</order></author><author><firstname>Constance&#xA0;B</firstname><surname>Bailey</surname><order>8</order></author><author><firstname>Lena</firstname><surname>Barra</surname><order>9</order></author><author><firstname>Thomas&#xA0;J</firstname><surname>Booth</surname><order>10</order></author><author><firstname>Kenan&#xA0;A J</firstname><surname>Bozh&#xFC;y&#xFC;k</surname><order>11</order></author><author><firstname>Jos&#xE9;&#xA0;D D</firstname><surname>Cediel-Becerra</surname><order>12</order></author><author><firstname>Zachary</firstname><surname>Charlop-Powers</surname><order>13</order></author><author><firstname>Marc&#xA0;G</firstname><surname>Chevrette</surname><order>14</order></author><author><firstname>Yit Heng</firstname><surname>Chooi</surname><order>15</order></author><author><firstname>Paul&#xA0;M</firstname><surname>D&#x2019;Agostino</surname><order>16</order></author><author><firstname>Tristan</firstname><surname>de&#xA0;Rond</surname><order>17</order></author><author><firstname>Elena</firstname><surname>Del&#xA0;Pup</surname><order>18</order></author><author><firstname>Katherine&#xA0;R</firstname><surname>Duncan</surname><order>19</order></author><author><firstname>Wenjia</firstname><surname>Gu</surname><order>20</order></author><author><firstname>Novriyandi</firstname><surname>Hanif</surname><order>21</order></author><author><firstname>Eric&#xA0;J N</firstname><surname>Helfrich</surname><order>22</order></author><author><firstname>Matthew</firstname><surname>Jenner</surname><order>23</order></author><author><firstname>Yohei</firstname><surname>Katsuyama</surname><order>24</order></author><author><firstname>Aleksandra</firstname><surname>Korenskaia</surname><order>25</order></author><author><firstname>Daniel</firstname><surname>Krug</surname><order>26</order></author><author><firstname>Vincent</firstname><surname>Libis</surname><order>27</order></author><author><firstname>George&#xA0;A</firstname><surname>Lund</surname><order>28</order></author><author><firstname>Shrikant</firstname><surname>Mantri</surname><order>29</order></author><author><firstname>Kalindi&#xA0;D</firstname><surname>Morgan</surname><order>30</order></author><author><firstname>Charlotte</firstname><surname>Owen</surname><order>31</order></author><author><firstname>Chin-Soon</firstname><surname>Phan</surname><order>32</order></author><author><firstname>Benjamin</firstname><surname>Philmus</surname><order>33</order></author><author><firstname>Zachary&#xA0;L</firstname><surname>Reitz</surname><order>34</order></author><author><firstname>Serina&#xA0;L</firstname><surname>Robinson</surname><order>35</order></author><author><firstname>Kumar Saurabh</firstname><surname>Singh</surname><order>36</order></author><author><firstname>Robin</firstname><surname>Teufel</surname><order>37</order></author><author><firstname>Yaojun</firstname><surname>Tong</surname><order>38</order></author><author><firstname>Fidele</firstname><surname>Tugizimana</surname><order>39</order></author><author><firstname>Dana</firstname><surname>Ulanova</surname><order>40</order></author><author><firstname>Jaclyn&#xA0;M</firstname><surname>Winter</surname><order>41</order></author><author><firstname>C&#xE9;sar</firstname><surname>Aguilar</surname><order>42</order></author><author><firstname>Daniel&#xA0;Y</firstname><surname>Akiyama</surname><order>43</order></author><author><firstname>Suhad&#xA0;A A</firstname><surname>Al-Salihi</surname><order>44</order></author><author><firstname>Mohammad</firstname><surname>Alanjary</surname><order>45</order></author><author><firstname>Fabrizio</firstname><surname>Alberti</surname><order>46</order></author><author><firstname>Gajender</firstname><surname>Aleti</surname><order>47</order></author><author><firstname>Shumukh&#xA0;A</firstname><surname>Alharthi</surname><order>48</order></author><author><firstname>Mariela&#xA0;Y Arias</firstname><surname>Rojo</surname><order>49</order></author><author><firstname>Amr&#xA0;A</firstname><surname>Arishi</surname><order>50</order></author><author><firstname>Hannah&#xA0;E</firstname><surname>Augustijn</surname><order>51</order></author><author><firstname>Nicole&#xA0;E</firstname><surname>Avalon</surname><order>52</order></author><author><firstname>J&#xA0;Abraham</firstname><surname>Avelar-Rivas</surname><order>53</order></author><author><firstname>Kyle&#xA0;K</firstname><surname>Axt</surname><order>54</order></author><author><firstname>Hellen&#xA0;B</firstname><surname>Barbieri</surname><order>55</order></author><author><firstname>Julio&#xA0;Cesar&#xA0;J</firstname><surname>Barbosa</surname><order>56</order></author><author><firstname>Lucas 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Ahmed</firstname><surname>Chaudhri</surname><order>82</order></author><author><firstname>Vasvi</firstname><surname>Chaudhry</surname><order>83</order></author><author><firstname>Hyukjae</firstname><surname>Choi</surname><order>84</order></author><author><firstname>Yukyung</firstname><surname>Choi</surname><order>85</order></author><author><firstname>Roya</firstname><surname>Choupannejad</surname><order>86</order></author><author><firstname>Jakub</firstname><surname>Chromy</surname><order>87</order></author><author><firstname>Melinda&#xA0;S 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Maharai</firstname><surname>Martinez-Martinez</surname><order>184</order></author><author><firstname>Yvonne</firstname><surname>Mast</surname><order>185</order></author><author><firstname>Marina&#xA0;F</firstname><surname>Maximo</surname><order>186</order></author><author><firstname>Christina&#xA0;M</firstname><surname>McBride</surname><order>187</order></author><author><firstname>Rose&#xA0;M</firstname><surname>McLellan</surname><order>188</order></author><author><firstname>Khyati 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spelling 2025-01-30T13:36:12.6399744 v2 68571 2024-12-16 MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration f6a4027578a15ea3e6453a54b849c686 0000-0001-6959-5100 Eva C. Sonnenschein Eva C. Sonnenschein true false 78d65007643ec30405caaf9df99c06e8 Shumukh Alharthi Shumukh Alharthi true false cacac6459bd7cf4a241f63661006036f 0000-0003-3067-0999 Claudio Greco Claudio Greco true false 2024-12-16 BGPS Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/. Journal Article Nucleic Acids Research 53 D1 D678 D690 Oxford University Press (OUP) 0305-1048 1362-4962 6 1 2025 2025-01-06 10.1093/nar/gkae1115 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University Another institution paid the OA fee M.M.Z. was supported by the NWO Grant KICH1.LWV04.21.013 and by the Horizon 2020 Grant 101000392; C.L. was supported by the NWO Open Science Project 'BiG-CODEC' No. OSF.23.1.044; C.D.B was supported by the German Research Foundation Grant No. 547394769; C.B.B. was supported by the University of Sydney Drug Discovery Initiative; T.J.B was supported by the Novo Nodisk Foundation Grant NNF22OC0078997; Y.H.C. was supported by the Australian Research Council Industry Fellowship IM230100154; P.M.D. was supported by the Hans Fischer Society; K.R.D. was supported by the UK Government Department for Environment, Food & Rural Affairs (DEFRA) Global Centre on Biodiversity for the Climate and by the United Kingdom Research and Innovation (EP/X03142X/1) and by the Horizon Europe Marie Skłodowska-Curie grant agreement No 101072485; N.H. was supported by the Indonesia Endowment Fund for Education Agency (LPDP) and National Research and Innovation Agency (BRIN) of the Republic of Indonesia (106/IV/KS/11/2023 and 41644/IT3/PT.01.03/P/B/2023) and by the the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia (027/E5/PG.02.00.PL/2024); M.J. was supported by the UKRI Future Leaders Fellowship (MR/W011247/1); A.Korenskaia was supported by the Horizon Europe Marie Skłodowska-Curie grant agreement No 101072485; V.L. was supported by the ERC Starting Grant 101117891-MeDiSyn and by the Agence Nationale de la Recherche project ANR-22-CE44-0011-01 UMISYN; G.A.L. was supported by the Growing Health Institute Strategic Programme (BB/X010953/1; BBS/E/RH/230003B); S.M. was supported by the Department of Biotechnology (DBT), Government of India and by the National Agri-Food Biotechnology Institute (NABI); C-S.P. was supported by the EU project No. 101087181 (Natural Products Research at Latvian Institute of Organic Synthesis as a Driver for Excellence in Innovation); R.T. was supported by the Swiss National Science Foundation (SNSF), grant 212747; Y.T. was supported by the National Key Research and Development Program of China (2021YFA0909500) and by the the National Natural Science Foundation of China (32170080 and 32370026) and by the Shanghai Pilot Program for Basic Research - Shanghai Jiao Tong University; D.U. was supported by the Japan Society for Promotion of Science KAKENHI grant number 21K06336; D.Y.A. was supported by the São Paulo Research Foundation (FAPESP) research scholarship (grant 21/07038-0); M.A. was supported by the NWO Talent programme Veni science domain (VI.Veni.202.130); F.A. was supported by the UKRI Future Leaders Fellowship (MR/V022334/1); G.A. was supported by the USDA Evans-Allen Research Grant (222676); N.E.A. was supported by the National Center for Complementary and Integrative Health of the NIH under award number F32AT011475; H.B.B. was supported by the São Paulo Research Foundation (FAPESP) research scholarship (grant 21/08947-3); S.E.B. was supported by the National Science Foundation Graduate Research Fellowship (DGE 21-46756) and by the the University of Illinois Urbana-Champaign Illinois Distinguished Fellowship; C.B. was supported by the European Union Horizon 2020 research and innovation program (ERC Grant number: 802736, MORPHEUS); J.B-A. was supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT) [735867]; K.M.B. was supported by the NWO Merian fund (Micro-GRICE); M.W.B. was supported by the United Kingdom Research and Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC) funded White Rose Mechanistic and Structural Biology Doctoral Training Program (BB/T007222/1); L.B. was supported by the Horizon Europe Marie Skłodowska-Curie Actions Postdoctoral Fellowship funded by the European Union (Project chelOMICS - grant agreement No. 101066127); V.J.C. was supported by the Ministerio de Ciencia, Innovación y Universidades project RYC2020-029240-I; R.C-B. was supported by the scholarship SFRH/BD/136367/2018 by Fundaçao para a Ciencia e Tecnologia (FCT); G.C-F. was supported by the National Institutes of Health (NIH)/NIGMS K12 GM068524 Award as a San Diego IRACDA Scholar.; E.C-G. was supported by the HZI POF IV Cooperativity and Creativity Project Call; V.C. was supported by the Alexander von Humboldt-Stiftung (Ref: 3.5-IND-1199743-HFST-P) and by the Cluster of Excellence: Controlling Microbes to Fight Infection (CMFI-YIG (EXC-2124/1-09.029_0; H.C. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1A6A1A03044512, and NRF-2021R1A2C1010727); Y.C. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1C1C1004046 and NRF-2022R1A5A2021216); J.A.C. was supported by the Signals in the Soil program via UK Research and Innovation (UKRI; NE/T010959/1); K.E.C. was supported by the Chan Zuckerberg Initiative Foundation grant number CZIF2022-007203; M.C. was supported by the German Research Foundation (DFG) Grant No. 495740318; J-F.D. was supported by the Agence Nationale de la Recherche (ShySM grant ANR-24-CE20-7299-01 and by the EUR Saclay Plant Sciences-SPS (ANR-17-EUR-0007); L.C.D-R. was supported by the European Union's Horizon Europe programme under the Marie Skłodowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); T.D. was supported by the European Regional Development Fund, Programme Johannes Amos Comenius project ‘IOCB MSCA PF Mobility’ no. CZ.02.01.01/00/22_010/0002733; M.dK. was supported by the European Union's Horizon 2020 research and innovation program (ERC Grant number: 802736, MORPHEUS).; A.Fetter was supported by the United Kingdom Research and Innovation (EP/X03142X/1) and by the Horizon Europe Marie Skłodowska-Curie grant agreement No 101072485; M.F. was supported by the Swiss Federal Government through the State Secretariat for Education, Research and Innovation SERI; A.Frediansyah was supported by the Fulbright Grant (PS00349981); A.Gavriilidou was supported by the Deutsche Forschungsgemeinschaft [398967434-TRR 261]; A.Gentile was supported by the Italian Ministry of Research (Grant DM60066); H.G. was supported by the Research Foundation–Flanders (FWO) under the scope of junior postdoctoral fellowship (1229222N); L.A.G-S. was supported by the CONAHCYT scholarship (#971765); N.E.G. was supported by the NIGMS R01-GM146224, NERRS NA22NOS4200050; C.G. was supported by the BBSRC (BB/V005723/2); J.E.G.G. was supported by the CONAHCYT scholarship (#1347411); S.G. was supported by the National Institutes of Health (NIH), Grant T32GM136583. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.; L.H. was supported by the NIH F31 1F31ES036421-01; T.Hebra was supported by the European Union's Horizon Europe research and innovation program under the Marie Skłodowska-Curie grant agreement No. 101130799; T.Horch was supported by the Novo Nordisk Foundation grant-number: CFB 2.0, NNF20CC0035580; M.I. was supported by the Italian Ministry of Research (Grant DM60066); E.J. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1C1C1004046 and NRF-2022R1A5A2021216); K.B.K. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1C1C1004046 and NRF-2022R1A5A2021216); S.K. was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-RS-2024-00408499) and by the National Research Foundation of Korea grants funded by the Republic of Korean Government (Ministry of Science and ICT) (NRF-RS-2024-00352229); W.K. was supported by the National Research Foundation of Korea grant funded by the Korea government (No. 2022R1C1C2004118); G.J.K. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1A6A1A03044512, and NRF-2021R1A2C1010727); H.K. was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIT) Grants NRF 2018R1A5A2023127 and RS-2023-00211868; M.K. was supported by the Werner Siemens Foundation grant Paleobiotechnology; R.A.K. was supported by the NWO-XL (OCENW.XL21.XL21.088); A.T.K. was supported by the Danish National Research Foundation CeMiSt, DNRF137 and by the Novo Nordisk Foundation INTERACT, NNF19SA0059360; A.M.K. was supported by the U.S. National Science Foundation (CBET-2032243); A.Kust was supported by the Delta Stewardship Council Delta Science Program; S.L. was supported by the European Research Council under European Union's Horizon 2020 Research and Innovation Program ERC St grant 852600 Lacto-Be; S-M.L. was supported by the Deutsche Forschungsgemeinschaft LI844/11-1 and LI844/14-1; A.L. was supported by the European Union's Horizon Europe programme under the Marie Skłodowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); M.I.M. was supported by the Conahcyt Mexico International PhD Studentship and by the Strathclyde University Global Research Scholarship; M.M. was supported by the Novo Nordisk Foundation (Grant NNF23OC0082881) and Innovation Fund Denmark (Grant 3141-00013A); Y.M. was supported by the Leibniz Association grant K445/2022; M.F.M. was supported by the São Paulo Research Foundation (FAPESP) research scholarship (grant 23/01956-2); C.M.M. was supported by the NSF GRFP (#DGE 2241144); C.M. was supported by the MiCRop Consortium (NWO/OCW grant no. 024.004.014); A.M. was supported by the Carlsberg Foundation (CF22-1239); G-S.N. was supported by the SINTEF internal projects, POP-SEP BiocatDB (102022750), SEP AGREE (102029187) and POS BIOINFO 2024 (102024676-14), European Union's Horizon 2020 research and innovation programme under Grant Agreement no. 101000392 (MARBLES), no. 101081957 (BLUETOOLS), and no. 862923 (AtlantECO); A.O. was supported by the Marie Sklodowska-Curie grant No. 101106349; B.O.O. was supported by the BG-21F, Ministry of Education and Science of Ukraine and by the 57/0009, National Research Fund of Ukraine (partial support); H.O. was supported by the Office of Science of the U.S. Department of Energy operated under Contract No. DE-AC02-05CH11231; L.P. was supported by the German Academic Scholarship Foundation; X.P. was supported by the NWO-XL grant OCENW.GROOT.2019.063; M.P. was supported by the Department of Biotechnology (DBT), Government of India and by the University Grants Commission (UGC), Ministry of Education, Government of India; M.P.R. was supported by the Spanish “Junta de Andalucía” project PROYEXCEL_00012; H.T.P. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1C1C1004046 and NRF-2022R1A5A2021216); S.J.P. was supported by the National Health and Medical Research Council GNT2021638, Australian Research Council Discovery Project DP230102668; B.P. was supported by the SECRETed EU Project Horizon 2020 (101000794); M.H.R. was supported by the European Research Council (ERC), European Union's Horizon 2020 Research and Innovation Program (grant agreement no. 865738); A.J.R. was supported by the Chemical-Biology Interface Training Grant (Grant T32-GM136629) and a National Science Foundation Graduate Research Fellowship (Grant DGE 21-46756); A.R. was supported by the ERC Advanced Grant 101055020-COMMUNITY; L.R.R-B. was supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT) [757173]; L.Salvi was supported by the European Union's Horizon Europe programme under the Marie Skłodowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); E.S-C. was supported by the PhD scholarships ANID N° 21231991; L.Sehnal was supported by the Horizon Europe Marie Skłodowska-Curie Actions Postdoctoral Fellowship funded by the European Union (Project NAfrAM - grant agreement No. 10106428); A.D.S. was supported by the Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership [BB/T008741/1]; T.K.S. was supported by the Novo Nordisk Foundation (Grant number: NNF22OC0080109); V.S. was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean Government (MSIT) (Grant No. NRF-2020R1A6A1A03044512, and NRF-2021R1A2C1010727); E.C.S. was supported by the Pathfinder Open 2022, a European Innovation Council (EIC) work programme that is part of Horizon Europe (grant agreement no. 101099528) and UK Innovation Funding Agency (UKRI) (reference no. 10062709).; M.S. was supported by the Italian Ministry of Research (Grant DM60066); K.S. was supported by the Swedish Pharmaceutical Society PostDoc stipend; A.B.S. was supported by the Swiss National Science Foundation (SNSF, 205320_219638); T.S. was supported by the Carlsberg Foundation (CF22-1239); J.S. was supported by the European Union's Horizon Europe programme under the Marie Skłodowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); A.T. was supported by the Saarland University through the NextAID project; M.J.T. was supported by the Pathfinder Open 2022, a European Innovation Council (EIC) work programme that is part of Horizon Europe (grant agreement no. 101099528) and UK Innovation Funding Agency (UKRI) (reference no. 10062709).; T.T. was supported by the Carlsberg Foundation (CF22-1239); A.W.T. was supported by the BBSRC Institute Strategic Program grant (BB/X01097X/1); M.T. was supported by the AUFF (AUFF-E-2022-9-42); L.V. was supported by the European Union's Horizon Europe programme under the Marie Skłodowska-Curie grant agreement No 101072485 (MAGic-MOLFUN); G.P.vW. was supported by the ERC Advanced Grant 101055020-COMMUNITY; K.W. was supported by the MR/N029909/1, Medical Research Council, UK; S.E.W. was supported by the Novo Nordisk Foundation Postdoctoral Fellowship (NNF22OC0079021); T.E.W. was supported by the Natural Science and Research Council of Canada PGS-D scholarship; D.Y. was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Grant RS-2024-00440975); A.Z. was supported by the German Center for Infection Research (DZIF) (TTU 09.826); C.Z. was supported by the Austrian Science Fund (FWF) [10.55776/P 34036]; R.G.L. was supported by the Natural Sciences and Engineering Research Council of Canada Discovery Grant program; T.W. was supported by the Novo Nordisk Foundation, NNF20CC0035580 and by the Danish National Research Foundation CeMiSt, DNRF137 and by the European Union's Horizon Europe programme under the Marie Skłodowska-Curie grant agreement No 101072485 (MAGic-MOLFUN). 2025-01-30T13:36:12.6399744 2024-12-16T06:32:21.4723931 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Eva C. Sonnenschein 0000-0001-6959-5100 1 Mitja M Zdouc 2 Kai Blin 0000-0003-3764-6051 3 Nico L L Louwen 4 Jorge Navarro 0000-0003-2992-1607 5 Catarina Loureiro 0000-0002-6258-2080 6 Chantal D Bader 7 Constance B Bailey 8 Lena Barra 9 Thomas J Booth 10 Kenan A J Bozhüyük 11 José D D Cediel-Becerra 12 Zachary Charlop-Powers 13 Marc G Chevrette 14 Yit Heng Chooi 15 Paul M D’Agostino 16 Tristan de Rond 17 Elena Del Pup 18 Katherine R Duncan 19 Wenjia Gu 20 Novriyandi Hanif 21 Eric J N Helfrich 22 Matthew Jenner 23 Yohei Katsuyama 24 Aleksandra Korenskaia 25 Daniel Krug 26 Vincent Libis 27 George A Lund 28 Shrikant Mantri 29 Kalindi D Morgan 30 Charlotte Owen 31 Chin-Soon Phan 32 Benjamin Philmus 33 Zachary L Reitz 34 Serina L Robinson 35 Kumar Saurabh Singh 36 Robin Teufel 37 Yaojun Tong 38 Fidele Tugizimana 39 Dana Ulanova 40 Jaclyn M Winter 41 César Aguilar 42 Daniel Y Akiyama 43 Suhad A A Al-Salihi 44 Mohammad Alanjary 45 Fabrizio Alberti 46 Gajender Aleti 47 Shumukh A Alharthi 48 Mariela Y Arias Rojo 49 Amr A Arishi 50 Hannah E Augustijn 51 Nicole E Avalon 52 J Abraham Avelar-Rivas 53 Kyle K Axt 54 Hellen B Barbieri 55 Julio Cesar J Barbosa 56 Lucas Gabriel Barboza Segato 57 Susanna E Barrett 58 Martin Baunach 59 Christine Beemelmanns 60 Dardan Beqaj 61 Tim Berger 62 Jordan Bernaldo-Agüero 63 Sandra M Bettenbühl 64 Vincent A Bielinski 65 Friederike Biermann 66 Ricardo M Borges 67 Rainer Borriss 68 Milena Breitenbach 69 Kevin M Bretscher 70 Michael W Brigham 71 Larissa Buedenbender 72 Brodie W Bulcock 73 Carolina Cano-Prieto 74 João Capela 75 Victor J Carrion 76 Riley S Carter 77 Raquel Castelo-Branco 78 Gabriel Castro-Falcón 79 Fernanda O Chagas 80 Esteban Charria-Girón 81 Ayesha Ahmed Chaudhri 82 Vasvi Chaudhry 83 Hyukjae Choi 84 Yukyung Choi 85 Roya Choupannejad 86 Jakub Chromy 87 Melinda S Chue Donahey 0000-0002-3565-7737 88 Jérôme Collemare 89 Jack A Connolly 90 Kaitlin E Creamer 91 Max Crüsemann 92 Andres Arredondo Cruz 93 Andres Cumsille 94 Jean-Felix Dallery 95 Luis Caleb Damas-Ramos 96 Tito Damiani 97 Martinus de Kruijff 98 Belén Delgado Martín 99 Gerardo Della Sala 100 Jelle Dillen 101 Drew T Doering 102 Shravan R Dommaraju 103 Suhan Durusu 104 Susan Egbert 105 Mark Ellerhorst 106 Baptiste Faussurier 107 Artem Fetter 108 Marc Feuermann 109 David P Fewer 110 Jonathan Foldi 111 Andri Frediansyah 112 Erin A Garza 113 Athina Gavriilidou 114 Andrea Gentile 115 Jennifer Gerke 116 Hans Gerstmans 117 Juan Pablo Gomez-Escribano 118 Luz A González-Salazar 119 Natalie E Grayson 120 Claudio Greco 121 Juan E Gris Gomez 122 Sebastian Guerra 123 Shaday Guerrero Flores 124 Alexey Gurevich 125 Karina Gutiérrez-García 126 Lauren Hart 127 Kristina Haslinger 128 Beibei He 129 Teo Hebra 130 Jethro L Hemmann 131 Hindra Hindra 132 Lars Höing 133 Darren C Holland 134 Jonathan E Holme 135 Therese Horch 136 Pavlo Hrab 137 Jie Hu 138 Thanh-Hau Huynh 139 Ji-Yeon Hwang 140 Riccardo Iacovelli 141 Dumitrita Iftime 142 Marianna Iorio 143 Sidharth Jayachandran 144 Eunah Jeong 145 Jiayi Jing 146 Jung J Jung 147 Yuya Kakumu 148 Edward Kalkreuter 149 Kyo Bin Kang 150 Sangwook Kang 151 Wonyong Kim 152 Geum Jin Kim 153 Hyunwoo Kim 154 Hyun Uk Kim 155 Martin Klapper 156 Robert A Koetsier 157 Cassandra Kollten 158 Ákos T Kovács 159 Yelyzaveta Kriukova 160 Noel Kubach 161 Aditya M Kunjapur 162 Aleksandra K Kushnareva 163 Andreja Kust 164 Jessica Lamber 165 Martin Larralde 166 Niels J Larsen 167 Adrien P Launay 168 Ngoc-Thao-Hien Le 169 Sarah Lebeer 170 Byung Tae Lee 171 Kyungha Lee 172 Katherine L Lev 173 Shu-Ming Li 174 Yong-Xin Li 175 Cuauhtémoc Licona-Cassani 176 Annette Lien 177 Jing Liu 178 Julius Adam V Lopez 179 Nataliia V Machushynets 180 Marla I Macias 181 Taifo Mahmud 182 Matiss Maleckis 183 Añadir Maharai Martinez-Martinez 184 Yvonne Mast 185 Marina F Maximo 186 Christina M McBride 187 Rose M McLellan 188 Khyati Mehta Bhatt 189 Chrats Melkonian 190 Aske Merrild 191 Mikko Metsä-Ketelä 192 Douglas A Mitchell 193 Alison V Müller 194 Giang-Son Nguyen 195 Hera T Nguyen 196 Timo H J Niedermeyer 197 Julia H O’Hare 198 Adam Ossowicki 199 Bohdan O Ostash 200 Hiroshi Otani 201 Leo Padva 202 Sunaina Paliyal 203 Xinya Pan 204 Mohit Panghal 205 Dana S Parade 206 Jiyoon Park 207 Jonathan Parra 208 Marcos Pedraza Rubio 209 Huong T Pham 210 Sacha J Pidot 211 Jörn Piel 212 Bita Pourmohsenin 213 Malik Rakhmanov 214 Sangeetha Ramesh 215 Michelle H Rasmussen 216 Adriana Rego 217 Raphael Reher 218 Andrew J Rice 219 Augustin Rigolet 220 Adriana Romero-Otero 221 Luis Rodrigo Rosas-Becerra 222 Pablo Y Rosiles 223 Adriano Rutz 224 Byeol Ryu 225 Libby-Ann Sahadeo 226 Murrel Saldanha 227 Luca Salvi 228 Eduardo Sánchez-Carvajal 229 Christian Santos-Medellin 230 Nicolau Sbaraini 231 Sydney M Schoellhorn 232 Clemens Schumm 233 Ludek Sehnal 234 Nelly Selem 235 Anjali D Shah 236 Tania K Shishido 237 Simon Sieber 238 Velina Silviani 239 Garima Singh 240 Hemant Singh 241 Nika Sokolova 242 Eva C Sonnenschein 243 Margherita Sosio 244 Sven T Sowa 245 Karin Steffen 246 Evi Stegmann 247 Alena B Streiff 248 Alena Strüder 249 Frank Surup 250 Tiziana Svenningsen 251 Douglas Sweeney 252 Judit Szenei 253 Azat Tagirdzhanov 254 Bin Tan 255 Matthew J Tarnowski 256 Barbara R Terlouw 257 Thomas Rey 258 Nicola U Thome 259 Laura Rosina Torres Ortega 260 Thomas Tørring 261 Marla Trindade 262 Andrew W Truman 263 Marie Tvilum 264 Daniel W Udwary 265 Christoph Ulbricht 266 Lisa Vader 267 Gilles P van Wezel 268 Max Walmsley 269 Randika Warnasinghe 270 Heiner G Weddeling 271 Angus N M Weir 272 Katherine Williams 273 Sam E Williams 274 Thomas E Witte 275 Steffaney M Wood Rocca 276 Keith Yamada 277 Dong Yang 278 Dongsoo Yang 279 Jingwei Yu 280 Zhenyi Zhou 281 Nadine Ziemert 282 Lukas Zimmer 283 Alina Zimmermann 284 Christian Zimmermann 285 Justin J J van der Hooft 0000-0002-9340-5511 286 Roger G Linington 0000-0003-1818-4971 287 Tilmann Weber 0000-0002-8260-5120 288 Marnix H Medema 0000-0002-2191-2821 289 Shumukh Alharthi 290 Claudio Greco 0000-0003-3067-0999 291 68571__33440__4a2011c3831b4b27a204030cfe7ca1bf.pdf 68571.VoR.pdf 2025-01-30T13:33:05.1447048 Output 1380110 application/pdf Version of Record true ©The Author(s) 2024. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. true eng https://creativecommons.org/licenses/by/4.0/deed.en
title MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
spellingShingle MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Eva C. Sonnenschein
Shumukh Alharthi
Claudio Greco
title_short MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
title_full MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
title_fullStr MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
title_full_unstemmed MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
title_sort MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
author_id_str_mv f6a4027578a15ea3e6453a54b849c686
78d65007643ec30405caaf9df99c06e8
cacac6459bd7cf4a241f63661006036f
author_id_fullname_str_mv f6a4027578a15ea3e6453a54b849c686_***_Eva C. Sonnenschein
78d65007643ec30405caaf9df99c06e8_***_Shumukh Alharthi
cacac6459bd7cf4a241f63661006036f_***_Claudio Greco
author Eva C. Sonnenschein
Shumukh Alharthi
Claudio Greco
author2 Eva C. Sonnenschein
Mitja M Zdouc
Kai Blin
Nico L L Louwen
Jorge Navarro
Catarina Loureiro
Chantal D Bader
Constance B Bailey
Lena Barra
Thomas J Booth
Kenan A J Bozhüyük
José D D Cediel-Becerra
Zachary Charlop-Powers
Marc G Chevrette
Yit Heng Chooi
Paul M D’Agostino
Tristan de Rond
Elena Del Pup
Katherine R Duncan
Wenjia Gu
Novriyandi Hanif
Eric J N Helfrich
Matthew Jenner
Yohei Katsuyama
Aleksandra Korenskaia
Daniel Krug
Vincent Libis
George A Lund
Shrikant Mantri
Kalindi D Morgan
Charlotte Owen
Chin-Soon Phan
Benjamin Philmus
Zachary L Reitz
Serina L Robinson
Kumar Saurabh Singh
Robin Teufel
Yaojun Tong
Fidele Tugizimana
Dana Ulanova
Jaclyn M Winter
César Aguilar
Daniel Y Akiyama
Suhad A A Al-Salihi
Mohammad Alanjary
Fabrizio Alberti
Gajender Aleti
Shumukh A Alharthi
Mariela Y Arias Rojo
Amr A Arishi
Hannah E Augustijn
Nicole E Avalon
J Abraham Avelar-Rivas
Kyle K Axt
Hellen B Barbieri
Julio Cesar J Barbosa
Lucas Gabriel Barboza Segato
Susanna E Barrett
Martin Baunach
Christine Beemelmanns
Dardan Beqaj
Tim Berger
Jordan Bernaldo-Agüero
Sandra M Bettenbühl
Vincent A Bielinski
Friederike Biermann
Ricardo M Borges
Rainer Borriss
Milena Breitenbach
Kevin M Bretscher
Michael W Brigham
Larissa Buedenbender
Brodie W Bulcock
Carolina Cano-Prieto
João Capela
Victor J Carrion
Riley S Carter
Raquel Castelo-Branco
Gabriel Castro-Falcón
Fernanda O Chagas
Esteban Charria-Girón
Ayesha Ahmed Chaudhri
Vasvi Chaudhry
Hyukjae Choi
Yukyung Choi
Roya Choupannejad
Jakub Chromy
Melinda S Chue Donahey
Jérôme Collemare
Jack A Connolly
Kaitlin E Creamer
Max Crüsemann
Andres Arredondo Cruz
Andres Cumsille
Jean-Felix Dallery
Luis Caleb Damas-Ramos
Tito Damiani
Martinus de Kruijff
Belén Delgado Martín
Gerardo Della Sala
Jelle Dillen
Drew T Doering
Shravan R Dommaraju
Suhan Durusu
Susan Egbert
Mark Ellerhorst
Baptiste Faussurier
Artem Fetter
Marc Feuermann
David P Fewer
Jonathan Foldi
Andri Frediansyah
Erin A Garza
Athina Gavriilidou
Andrea Gentile
Jennifer Gerke
Hans Gerstmans
Juan Pablo Gomez-Escribano
Luz A González-Salazar
Natalie E Grayson
Claudio Greco
Juan E Gris Gomez
Sebastian Guerra
Shaday Guerrero Flores
Alexey Gurevich
Karina Gutiérrez-García
Lauren Hart
Kristina Haslinger
Beibei He
Teo Hebra
Jethro L Hemmann
Hindra Hindra
Lars Höing
Darren C Holland
Jonathan E Holme
Therese Horch
Pavlo Hrab
Jie Hu
Thanh-Hau Huynh
Ji-Yeon Hwang
Riccardo Iacovelli
Dumitrita Iftime
Marianna Iorio
Sidharth Jayachandran
Eunah Jeong
Jiayi Jing
Jung J Jung
Yuya Kakumu
Edward Kalkreuter
Kyo Bin Kang
Sangwook Kang
Wonyong Kim
Geum Jin Kim
Hyunwoo Kim
Hyun Uk Kim
Martin Klapper
Robert A Koetsier
Cassandra Kollten
Ákos T Kovács
Yelyzaveta Kriukova
Noel Kubach
Aditya M Kunjapur
Aleksandra K Kushnareva
Andreja Kust
Jessica Lamber
Martin Larralde
Niels J Larsen
Adrien P Launay
Ngoc-Thao-Hien Le
Sarah Lebeer
Byung Tae Lee
Kyungha Lee
Katherine L Lev
Shu-Ming Li
Yong-Xin Li
Cuauhtémoc Licona-Cassani
Annette Lien
Jing Liu
Julius Adam V Lopez
Nataliia V Machushynets
Marla I Macias
Taifo Mahmud
Matiss Maleckis
Añadir Maharai Martinez-Martinez
Yvonne Mast
Marina F Maximo
Christina M McBride
Rose M McLellan
Khyati Mehta Bhatt
Chrats Melkonian
Aske Merrild
Mikko Metsä-Ketelä
Douglas A Mitchell
Alison V Müller
Giang-Son Nguyen
Hera T Nguyen
Timo H J Niedermeyer
Julia H O’Hare
Adam Ossowicki
Bohdan O Ostash
Hiroshi Otani
Leo Padva
Sunaina Paliyal
Xinya Pan
Mohit Panghal
Dana S Parade
Jiyoon Park
Jonathan Parra
Marcos Pedraza Rubio
Huong T Pham
Sacha J Pidot
Jörn Piel
Bita Pourmohsenin
Malik Rakhmanov
Sangeetha Ramesh
Michelle H Rasmussen
Adriana Rego
Raphael Reher
Andrew J Rice
Augustin Rigolet
Adriana Romero-Otero
Luis Rodrigo Rosas-Becerra
Pablo Y Rosiles
Adriano Rutz
Byeol Ryu
Libby-Ann Sahadeo
Murrel Saldanha
Luca Salvi
Eduardo Sánchez-Carvajal
Christian Santos-Medellin
Nicolau Sbaraini
Sydney M Schoellhorn
Clemens Schumm
Ludek Sehnal
Nelly Selem
Anjali D Shah
Tania K Shishido
Simon Sieber
Velina Silviani
Garima Singh
Hemant Singh
Nika Sokolova
Eva C Sonnenschein
Margherita Sosio
Sven T Sowa
Karin Steffen
Evi Stegmann
Alena B Streiff
Alena Strüder
Frank Surup
Tiziana Svenningsen
Douglas Sweeney
Judit Szenei
Azat Tagirdzhanov
Bin Tan
Matthew J Tarnowski
Barbara R Terlouw
Thomas Rey
Nicola U Thome
Laura Rosina Torres Ortega
Thomas Tørring
Marla Trindade
Andrew W Truman
Marie Tvilum
Daniel W Udwary
Christoph Ulbricht
Lisa Vader
Gilles P van Wezel
Max Walmsley
Randika Warnasinghe
Heiner G Weddeling
Angus N M Weir
Katherine Williams
Sam E Williams
Thomas E Witte
Steffaney M Wood Rocca
Keith Yamada
Dong Yang
Dongsoo Yang
Jingwei Yu
Zhenyi Zhou
Nadine Ziemert
Lukas Zimmer
Alina Zimmermann
Christian Zimmermann
Justin J J van der Hooft
Roger G Linington
Tilmann Weber
Marnix H Medema
Shumukh Alharthi
Claudio Greco
format Journal article
container_title Nucleic Acids Research
container_volume 53
container_issue D1
container_start_page D678
publishDate 2025
institution Swansea University
issn 0305-1048
1362-4962
doi_str_mv 10.1093/nar/gkae1115
publisher Oxford University Press (OUP)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.
published_date 2025-01-06T05:25:49Z
_version_ 1851097716654866432
score 11.444473

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