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Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing

Thomas O’Toole, Christopher J. Armitage, Martie van Tongeren, Kim Dienes Orcid Logo

Psychoneuroendocrinology, Volume: 171, Start page: 107193

Swansea University Author: Kim Dienes Orcid Logo

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DOI (Published version): 10.1016/j.psyneuen.2024.107193

Abstract

Evidence suggests that chronic cortisol excess may precede the development of an allostatic load, and that this association may be influenced by the level of work stress. This study aims to investigate the associations between hair cortisol concentration and the development of systemic allostatic lo...

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Published in: Psychoneuroendocrinology
ISSN: 0306-4530 1873-3360
Published: Elsevier BV 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa68315
first_indexed 2024-12-09T19:47:08Z
last_indexed 2025-01-14T14:38:19Z
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spelling 2025-01-14T10:45:56.9227535 v2 68315 2024-11-21 Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing 76108f6ac5e9dccfc581a09f7e5ef333 0000-0002-6119-7025 Kim Dienes Kim Dienes true false 2024-11-21 PSYS Evidence suggests that chronic cortisol excess may precede the development of an allostatic load, and that this association may be influenced by the level of work stress. This study aims to investigate the associations between hair cortisol concentration and the development of systemic allostatic load cross-sectionally and at a lag of four years, stratified by level of effort-reward imbalance.The sample consisted of respondents from the English Longitudinal Study of Ageing (ELSA) who were in employment with hair cortisol measurements at baseline (wave 6), and allostatic load markers at baseline and follow-up (wave 8; n=411; 64 % female). Hair cortisol was used as a measure of total cortisol expression over the preceding two months. Allostatic load was modelled as a count-based index using nine markers; three per system, across the immune, metabolic and cardiovascular systems. This model was then grouped by a median-cut effort reward-imbalance scale (0.83) and regression pathways were compared between groups using a series of Chi-Squared tests of difference.Results provide evidence that higher hair cortisol concentrations predict an increase in immune and cardiovascular allostatic load cross-sectionally, and a metabolic allostatic load at a lag of four years. These pathways were found in the high effort-reward imbalance group, but not in the low effort-reward imbalance group. There were also significant differences found between groups for hair cortisol concentration as a predictor of concurrent immune and cardiovascular allostatic loadFindings may indicate a novel temporality to the accumulation of an allostatic load, and that the “tipping point” between allostasis and allostatic load may lie within the ability of the HPA axis to regulate the cardiovascular system concurrently, with longitudinal consequences for metabolic syndrome indicators. Journal Article Psychoneuroendocrinology 171 107193 Elsevier BV 0306-4530 1873-3360 Allostatic Load, Allostasis, Hair Cortisol, Cohort Study, Effort-Reward Imbalance 1 1 2025 2025-01-01 10.1016/j.psyneuen.2024.107193 COLLEGE NANME Psychology School COLLEGE CODE PSYS Swansea University Another institution paid the OA fee This study has been delivered through the National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre (BRC) (NIHR203308) and the NIHR Greater Manchester Patient Safety Research Collaboration. The views expressed are those of the author(s) and not necessarily those of the, the NIHR or the Department of Health and Social Care. 2025-01-14T10:45:56.9227535 2024-11-21T10:38:47.4750108 Faculty of Medicine, Health and Life Sciences School of Psychology Thomas O’Toole 1 Christopher J. Armitage 2 Martie van Tongeren 3 Kim Dienes 0000-0002-6119-7025 4
title Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing
spellingShingle Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing
Kim Dienes
title_short Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing
title_full Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing
title_fullStr Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing
title_full_unstemmed Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing
title_sort Primary and secondary allostatic processes in the context of high-stress work: A multigroup moderation from the English longitudinal study of ageing
author_id_str_mv 76108f6ac5e9dccfc581a09f7e5ef333
author_id_fullname_str_mv 76108f6ac5e9dccfc581a09f7e5ef333_***_Kim Dienes
author Kim Dienes
author2 Thomas O’Toole
Christopher J. Armitage
Martie van Tongeren
Kim Dienes
format Journal article
container_title Psychoneuroendocrinology
container_volume 171
container_start_page 107193
publishDate 2025
institution Swansea University
issn 0306-4530
1873-3360
doi_str_mv 10.1016/j.psyneuen.2024.107193
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 0
active_str 0
description Evidence suggests that chronic cortisol excess may precede the development of an allostatic load, and that this association may be influenced by the level of work stress. This study aims to investigate the associations between hair cortisol concentration and the development of systemic allostatic load cross-sectionally and at a lag of four years, stratified by level of effort-reward imbalance.The sample consisted of respondents from the English Longitudinal Study of Ageing (ELSA) who were in employment with hair cortisol measurements at baseline (wave 6), and allostatic load markers at baseline and follow-up (wave 8; n=411; 64 % female). Hair cortisol was used as a measure of total cortisol expression over the preceding two months. Allostatic load was modelled as a count-based index using nine markers; three per system, across the immune, metabolic and cardiovascular systems. This model was then grouped by a median-cut effort reward-imbalance scale (0.83) and regression pathways were compared between groups using a series of Chi-Squared tests of difference.Results provide evidence that higher hair cortisol concentrations predict an increase in immune and cardiovascular allostatic load cross-sectionally, and a metabolic allostatic load at a lag of four years. These pathways were found in the high effort-reward imbalance group, but not in the low effort-reward imbalance group. There were also significant differences found between groups for hair cortisol concentration as a predictor of concurrent immune and cardiovascular allostatic loadFindings may indicate a novel temporality to the accumulation of an allostatic load, and that the “tipping point” between allostasis and allostatic load may lie within the ability of the HPA axis to regulate the cardiovascular system concurrently, with longitudinal consequences for metabolic syndrome indicators.
published_date 2025-01-01T20:36:13Z
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