Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6

Bain, Steve; Belmar, Nicolas; Hoff, Søren T.; Husain, Mansoor; Rasmussen, Søren; Vilsbøll, Tina; Petrie, Mark C.

doi:10.1007/s13300-024-01659-7

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Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6

Steve Bain

, Nicolas Belmar, Søren T. Hoff, Mansoor Husain, Søren Rasmussen, Tina Vilsbøll, Mark C. Petrie

Diabetes Therapy

Swansea University Author: Steve Bain

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DOI (Published version): 10.1007/s13300-024-01659-7

Abstract

IntroductionThe high risk of cardiovascular events in people with type 2 diabetes increases with age. The cardiovascular effects of once-weekly subcutaneous and once-daily oral semaglutide versus placebo in people with type 2 diabetes at high cardiovascular risk were investigated in the SUSTAIN 6 an...

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Published in:	Diabetes Therapy
ISSN:	1869-6953 1869-6961
Published:	Springer Science and Business Media LLC 2024
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa68224

first_indexed	2024-11-25T14:21:41Z
last_indexed	2024-11-25T14:21:41Z
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fullrecord	<?xml version="1.0"?><rfc1807><datestamp>2024-11-11T11:43:28.7999726</datestamp><bib-version>v2</bib-version><id>68224</id><entry>2024-11-11</entry><title>Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6</title><swanseaauthors><author><sid>5399f4c6e6a70f3608a084ddb938511a</sid><ORCID>0000-0001-8519-4964</ORCID><firstname>Steve</firstname><surname>Bain</surname><name>Steve Bain</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-11-11</date><deptcode>MEDS</deptcode><abstract>IntroductionThe high risk of cardiovascular events in people with type 2 diabetes increases with age. The cardiovascular effects of once-weekly subcutaneous and once-daily oral semaglutide versus placebo in people with type 2 diabetes at high cardiovascular risk were investigated in the SUSTAIN 6 and PIONEER 6 cardiovascular outcomes trials, respectively. It is unknown whether the effects of semaglutide are age dependent.MethodsThis post hoc analysis evaluated cardiovascular, metabolic, and safety outcomes with semaglutide versus placebo in age subgroups (≤ 60; > 60 to ≤ 65; > 65 to ≤ 70; and > 70 years) pooled from SUSTAIN 6 and PIONEER 6. Major adverse cardiovascular events (composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke), changes from baseline in glycated hemoglobin A1c (HbA1c) and body weight, and adverse events were analyzed.ResultsSemaglutide reduced major adverse cardiovascular events and its components versus placebo across age subgroups (most hazard ratios < 1.0; pinteraction > 0.05). The treatment difference in HbA1c reduction was greater in those aged ≤ 60 years than in older subgroups (pinteraction = 0.01). Reductions in body weight with semaglutide versus placebo were consistent across age subgroups (pinteraction = 0.124). Serious adverse events or severe hypoglycemic episodes did not differ between semaglutide and placebo across age subgroups.ConclusionSemaglutide consistently reduced major adverse cardiovascular events and body weight versus placebo across age subgroups; its safety profile did not differ with age. These results suggest that relaxing HbA1c targets based solely on age may not always be required for people with type 2 diabetes.</abstract><type>Journal Article</type><journal>Diabetes Therapy</journal><volume>0</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1869-6953</issnPrint><issnElectronic>1869-6961</issnElectronic><keywords>Cardiovascular; Glucagon-like peptide 1 receptor agonist; Metabolic; Safety; Type 2 diabetes</keywords><publishedDay>9</publishedDay><publishedMonth>11</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-11-09</publishedDate><doi>10.1007/s13300-024-01659-7</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>Other</apcterm><funders>SUSTAIN 6, PIONEER 6, and this post hoc analysis were funded by Novo Nordisk A/S. The sponsor designed the studies; funded the data collection, analysis, and interpretation; and was responsible for site monitoring, the writing of this report, and the decision to submit for publication. The journal’s Rapid Service Fee was funded by Novo Nordisk A/S.</funders><projectreference/><lastEdited>2024-11-11T11:43:28.7999726</lastEdited><Created>2024-11-11T11:28:26.3197099</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Biomedical Science</level></path><authors><author><firstname>Steve</firstname><surname>Bain</surname><orcid>0000-0001-8519-4964</orcid><order>1</order></author><author><firstname>Nicolas</firstname><surname>Belmar</surname><order>2</order></author><author><firstname>Søren T.</firstname><surname>Hoff</surname><order>3</order></author><author><firstname>Mansoor</firstname><surname>Husain</surname><order>4</order></author><author><firstname>Søren</firstname><surname>Rasmussen</surname><order>5</order></author><author><firstname>Tina</firstname><surname>Vilsbøll</surname><order>6</order></author><author><firstname>Mark C.</firstname><surname>Petrie</surname><order>7</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling	2024-11-11T11:43:28.7999726 v2 68224 2024-11-11 Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6 5399f4c6e6a70f3608a084ddb938511a 0000-0001-8519-4964 Steve Bain Steve Bain true false 2024-11-11 MEDS IntroductionThe high risk of cardiovascular events in people with type 2 diabetes increases with age. The cardiovascular effects of once-weekly subcutaneous and once-daily oral semaglutide versus placebo in people with type 2 diabetes at high cardiovascular risk were investigated in the SUSTAIN 6 and PIONEER 6 cardiovascular outcomes trials, respectively. It is unknown whether the effects of semaglutide are age dependent.MethodsThis post hoc analysis evaluated cardiovascular, metabolic, and safety outcomes with semaglutide versus placebo in age subgroups (≤ 60; > 60 to ≤ 65; > 65 to ≤ 70; and > 70 years) pooled from SUSTAIN 6 and PIONEER 6. Major adverse cardiovascular events (composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke), changes from baseline in glycated hemoglobin A1c (HbA1c) and body weight, and adverse events were analyzed.ResultsSemaglutide reduced major adverse cardiovascular events and its components versus placebo across age subgroups (most hazard ratios < 1.0; pinteraction > 0.05). The treatment difference in HbA1c reduction was greater in those aged ≤ 60 years than in older subgroups (pinteraction = 0.01). Reductions in body weight with semaglutide versus placebo were consistent across age subgroups (pinteraction = 0.124). Serious adverse events or severe hypoglycemic episodes did not differ between semaglutide and placebo across age subgroups.ConclusionSemaglutide consistently reduced major adverse cardiovascular events and body weight versus placebo across age subgroups; its safety profile did not differ with age. These results suggest that relaxing HbA1c targets based solely on age may not always be required for people with type 2 diabetes. Journal Article Diabetes Therapy 0 Springer Science and Business Media LLC 1869-6953 1869-6961 Cardiovascular; Glucagon-like peptide 1 receptor agonist; Metabolic; Safety; Type 2 diabetes 9 11 2024 2024-11-09 10.1007/s13300-024-01659-7 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Other SUSTAIN 6, PIONEER 6, and this post hoc analysis were funded by Novo Nordisk A/S. The sponsor designed the studies; funded the data collection, analysis, and interpretation; and was responsible for site monitoring, the writing of this report, and the decision to submit for publication. The journal’s Rapid Service Fee was funded by Novo Nordisk A/S. 2024-11-11T11:43:28.7999726 2024-11-11T11:28:26.3197099 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Steve Bain 0000-0001-8519-4964 1 Nicolas Belmar 2 Søren T. Hoff 3 Mansoor Husain 4 Søren Rasmussen 5 Tina Vilsbøll 6 Mark C. Petrie 7
title	Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6
spellingShingle	Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6 Steve Bain
title_short	Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6
title_full	Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6
title_fullStr	Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6
title_full_unstemmed	Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6
title_sort	Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6
author_id_str_mv	5399f4c6e6a70f3608a084ddb938511a
author_id_fullname_str_mv	5399f4c6e6a70f3608a084ddb938511a_***_Steve Bain
author	Steve Bain
author2	Steve Bain Nicolas Belmar Søren T. Hoff Mansoor Husain Søren Rasmussen Tina Vilsbøll Mark C. Petrie
format	Journal article
container_title	Diabetes Therapy
container_volume	0
publishDate	2024
institution	Swansea University
issn	1869-6953 1869-6961
doi_str_mv	10.1007/s13300-024-01659-7
publisher	Springer Science and Business Media LLC
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
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description	IntroductionThe high risk of cardiovascular events in people with type 2 diabetes increases with age. The cardiovascular effects of once-weekly subcutaneous and once-daily oral semaglutide versus placebo in people with type 2 diabetes at high cardiovascular risk were investigated in the SUSTAIN 6 and PIONEER 6 cardiovascular outcomes trials, respectively. It is unknown whether the effects of semaglutide are age dependent.MethodsThis post hoc analysis evaluated cardiovascular, metabolic, and safety outcomes with semaglutide versus placebo in age subgroups (≤ 60; > 60 to ≤ 65; > 65 to ≤ 70; and > 70 years) pooled from SUSTAIN 6 and PIONEER 6. Major adverse cardiovascular events (composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke), changes from baseline in glycated hemoglobin A1c (HbA1c) and body weight, and adverse events were analyzed.ResultsSemaglutide reduced major adverse cardiovascular events and its components versus placebo across age subgroups (most hazard ratios < 1.0; pinteraction > 0.05). The treatment difference in HbA1c reduction was greater in those aged ≤ 60 years than in older subgroups (pinteraction = 0.01). Reductions in body weight with semaglutide versus placebo were consistent across age subgroups (pinteraction = 0.124). Serious adverse events or severe hypoglycemic episodes did not differ between semaglutide and placebo across age subgroups.ConclusionSemaglutide consistently reduced major adverse cardiovascular events and body weight versus placebo across age subgroups; its safety profile did not differ with age. These results suggest that relaxing HbA1c targets based solely on age may not always be required for people with type 2 diabetes.
published_date	2024-11-09T08:30:22Z
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Cardiovascular, Metabolic, and Safety Outcomes with Semaglutide by Baseline Age: Post Hoc Analysis of SUSTAIN 6 and PIONEER 6

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