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Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry

Sare I Yavasoglu Orcid Logo, Martyn J Wood, James Bull Orcid Logo, Nergis Alkış Orcid Logo, Emrecan Doğan Orcid Logo, Abeer M Alkhaibari Orcid Logo, Tariq Butt Orcid Logo

Journal of Medical Entomology, Volume: 62, Issue: 1, Pages: 39 - 46

Swansea University Authors: James Bull Orcid Logo, Tariq Butt Orcid Logo

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DOI (Published version): 10.1093/jme/tjae137

Abstract

Mosquitoes threaten over half of the world’s population through vectored diseases such as malaria, zika, yellow fever, dengue, and chikungunya. Mosquitoes have a highly developed olfactory system attuned to chemotaxis relating to host-seeking, mating, and oviposition behavior. In this study, we aime...

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Published in: Journal of Medical Entomology
ISSN: 0022-2585 1938-2928
Published: Oxford University Press (OUP) 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa68141
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spelling 2025-02-13T11:51:35.2741671 v2 68141 2024-11-01 Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry 20742518482c020c80b81b88e5313356 0000-0002-4373-6830 James Bull James Bull true false 85d1c2ddde272a1176e74978e25ebece 0000-0002-8789-9543 Tariq Butt Tariq Butt true false 2024-11-01 BGPS Mosquitoes threaten over half of the world’s population through vectored diseases such as malaria, zika, yellow fever, dengue, and chikungunya. Mosquitoes have a highly developed olfactory system attuned to chemotaxis relating to host-seeking, mating, and oviposition behavior. In this study, we aimed to determine the spatial efficacy of 2 plant-based repellent blends (Blend3 and Blend4 that had previously been found to successfully repel Aedes, Anopheles and Culex mosquitoes in wind tunnel assays) in excluding Aedes aegypti from the window entry. A new cage system was developed for parallel “no-choice” and “choice” olfactometric assays. In the no-choice trial, Blends 3 and 4, as well as commercial products (N, N-diethyl-3-methylbenzamide, p-menthane-3,8-diol [PMD], 3-(N-n-butyl-N-acetyl)-amino-propionic acid ethyl ester, and 2-(2-hydroxyethyl)-1-methylpropylstyrene 1-piperidine carboxylate), were adsorbed into filter papers of different sizes and placed in a window created between 2 attached bug dorms. Then, the number of mosquitoes entering the window was counted through a 6-min period. In choice olfactometric assays, Blends 3, 4, and PMD were adsorbed into filter paper and the number of mosquitoes moving away from Blend 3 and PMD were compared. No-choice assays showed that Blend3 (P < 0.001) and Blend4 (P = 0.0012) were more repellent than the best commercial product PMD. Additionally, while Blend 4 was significantly more repellent than Blend 3 (P = 0.012) in the choice assay, overall, these 2 blends show promise as new repellents for the spatial exclusion of Aedes aegypti from window entry alone or as part of a “push-pull’’ strategy. Journal Article Journal of Medical Entomology 62 1 39 46 Oxford University Press (OUP) 0022-2585 1938-2928 Aedes aegypti, plant based, repellent olfactometric assay, “push-pull” strategy 1 1 2025 2025-01-01 10.1093/jme/tjae137 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University SU Library paid the OA fee (TA Institutional Deal) Swansea University 2025-02-13T11:51:35.2741671 2024-11-01T12:22:59.4738844 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Sare I Yavasoglu 0000-0002-9055-1556 1 Martyn J Wood 2 James Bull 0000-0002-4373-6830 3 Nergis Alkış 0009-0002-3407-1301 4 Emrecan Doğan 0009-0002-1368-4061 5 Abeer M Alkhaibari 0000-0003-4376-2438 6 Tariq Butt 0000-0002-8789-9543 7 68141__33259__272d886f6f05473f85f6ca37774db742.pdf 68141.VOR.pdf 2025-01-07T15:36:21.0527304 Output 879635 application/pdf Version of Record true © The Author(s) 2024. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0). true eng https://creativecommons.org/licenses/by/4.0/
title Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry
spellingShingle Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry
James Bull
Tariq Butt
title_short Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry
title_full Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry
title_fullStr Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry
title_full_unstemmed Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry
title_sort Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry
author_id_str_mv 20742518482c020c80b81b88e5313356
85d1c2ddde272a1176e74978e25ebece
author_id_fullname_str_mv 20742518482c020c80b81b88e5313356_***_James Bull
85d1c2ddde272a1176e74978e25ebece_***_Tariq Butt
author James Bull
Tariq Butt
author2 Sare I Yavasoglu
Martyn J Wood
James Bull
Nergis Alkış
Emrecan Doğan
Abeer M Alkhaibari
Tariq Butt
format Journal article
container_title Journal of Medical Entomology
container_volume 62
container_issue 1
container_start_page 39
publishDate 2025
institution Swansea University
issn 0022-2585
1938-2928
doi_str_mv 10.1093/jme/tjae137
publisher Oxford University Press (OUP)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description Mosquitoes threaten over half of the world’s population through vectored diseases such as malaria, zika, yellow fever, dengue, and chikungunya. Mosquitoes have a highly developed olfactory system attuned to chemotaxis relating to host-seeking, mating, and oviposition behavior. In this study, we aimed to determine the spatial efficacy of 2 plant-based repellent blends (Blend3 and Blend4 that had previously been found to successfully repel Aedes, Anopheles and Culex mosquitoes in wind tunnel assays) in excluding Aedes aegypti from the window entry. A new cage system was developed for parallel “no-choice” and “choice” olfactometric assays. In the no-choice trial, Blends 3 and 4, as well as commercial products (N, N-diethyl-3-methylbenzamide, p-menthane-3,8-diol [PMD], 3-(N-n-butyl-N-acetyl)-amino-propionic acid ethyl ester, and 2-(2-hydroxyethyl)-1-methylpropylstyrene 1-piperidine carboxylate), were adsorbed into filter papers of different sizes and placed in a window created between 2 attached bug dorms. Then, the number of mosquitoes entering the window was counted through a 6-min period. In choice olfactometric assays, Blends 3, 4, and PMD were adsorbed into filter paper and the number of mosquitoes moving away from Blend 3 and PMD were compared. No-choice assays showed that Blend3 (P < 0.001) and Blend4 (P = 0.0012) were more repellent than the best commercial product PMD. Additionally, while Blend 4 was significantly more repellent than Blend 3 (P = 0.012) in the choice assay, overall, these 2 blends show promise as new repellents for the spatial exclusion of Aedes aegypti from window entry alone or as part of a “push-pull’’ strategy.
published_date 2025-01-01T05:25:37Z
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