Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)

DUNN, JOSIE; Schifano, Fabrizio; Dudley, Ed; Guirguis, Amira

doi:10.3390/toxics12110777

Journal article 101 views

Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)

JOSIE DUNN, Fabrizio Schifano

, Ed Dudley, Amira Guirguis

Toxics, Volume: 12, Issue: 11, Start page: 777

Swansea University Authors: JOSIE DUNN, Ed Dudley, Amira Guirguis

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.3390/toxics12110777

Abstract

Introduction: Evidence suggests an increasing misuse of veterinary medicines by humans.This study aims to analyse Adverse Events (AEs) associated with selected veterinary productsusing the Food and Drug Administration Adverse Events Reporting System (FAERS). Methods: Adescriptive pharmacovigilance a...

Full description

Published in:	Toxics
ISSN:	2305-6304
Published:	MDPI AG 2024
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa68050

first_indexed	2024-10-23T13:55:51Z
last_indexed	2025-01-09T20:32:29Z
id	cronfa68050
recordtype	SURis
fullrecord	<?xml version="1.0"?><rfc1807><datestamp>2024-12-12T16:03:43.5259121</datestamp><bib-version>v2</bib-version><id>68050</id><entry>2024-10-23</entry><title>Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)</title><swanseaauthors><author><sid>8f5a87c617b03551d21ea17a4f2083b4</sid><firstname>JOSIE</firstname><surname>DUNN</surname><name>JOSIE DUNN</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>c7d05f992a817cd3b9a5f946bd909b71</sid><firstname>Ed</firstname><surname>Dudley</surname><name>Ed Dudley</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>b49270b9a0d580cf4f31f9a1b6c93f87</sid><ORCID>0000-0001-8255-0660</ORCID><firstname>Amira</firstname><surname>Guirguis</surname><name>Amira Guirguis</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-10-23</date><abstract>Introduction: Evidence suggests an increasing misuse of veterinary medicines by humans.This study aims to analyse Adverse Events (AEs) associated with selected veterinary productsusing the Food and Drug Administration Adverse Events Reporting System (FAERS). Methods: Adescriptive pharmacovigilance analysis was conducted on AEs related to 21 drugs approved forhuman and/or animal use. Results: A total of 38,756 AEs, including 9566 fatalities, were identified.The United States reported the highest number of cases (13,532), followed by Canada (2869) andthe United Kingdom (1400). Among the eight drugs licenced exclusively for animals, levamisole,pentobarbital, and xylazine were most frequently reported. Reports predominantly involved males(57%) from the 18–64 age group, with incidents related mainly to overdose, dependence, and multiagent toxicities. Unmasking techniques revealed ‘intentional overdose’ as the primary reaction.Polysubstance use was evident in 90% of the drugs, with benzodiazepines/Z-drugs and opioids ascommon co-used classes. Conclusions: Veterinary medications are increasingly infiltrating the illicitdrug market due to their pharmacological properties. This trend highlights the need for heightenedvigilance and awareness to prevent further public health risks associated with the adulteration ofillicit substances with veterinary products like xylazine and pentobarbital.</abstract><type>Journal Article</type><journal>Toxics</journal><volume>12</volume><journalNumber>11</journalNumber><paginationStart>777</paginationStart><paginationEnd/><publisher>MDPI AG</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2305-6304</issnElectronic><keywords>Veterinary medicines; animal medicines; substance use; pharmacovigilance; diversion of medicines; drug misuse</keywords><publishedDay>25</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2024</publishedYear><publishedDate>2024-10-25</publishedDate><doi>10.3390/toxics12110777</doi><url/><notes/><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm>Other</apcterm><funders>This research received no external funding.</funders><projectreference/><lastEdited>2024-12-12T16:03:43.5259121</lastEdited><Created>2024-10-23T14:46:31.3457871</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Pharmacy</level></path><authors><author><firstname>JOSIE</firstname><surname>DUNN</surname><order>1</order></author><author><firstname>Fabrizio</firstname><surname>Schifano</surname><orcid>0000-0002-4178-5401</orcid><order>2</order></author><author><firstname>Ed</firstname><surname>Dudley</surname><order>3</order></author><author><firstname>Amira</firstname><surname>Guirguis</surname><orcid>0000-0001-8255-0660</orcid><order>4</order></author></authors><documents><document><filename>68050__32888__b4018248d32d4915b518ec7e214bf3f6.pdf</filename><originalFilename>68050.VOR.pdf</originalFilename><uploaded>2024-11-07T15:10:16.1306913</uploaded><type>Output</type><contentLength>833090</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© 2024 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling	2024-12-12T16:03:43.5259121 v2 68050 2024-10-23 Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS) 8f5a87c617b03551d21ea17a4f2083b4 JOSIE DUNN JOSIE DUNN true false c7d05f992a817cd3b9a5f946bd909b71 Ed Dudley Ed Dudley true false b49270b9a0d580cf4f31f9a1b6c93f87 0000-0001-8255-0660 Amira Guirguis Amira Guirguis true false 2024-10-23 Introduction: Evidence suggests an increasing misuse of veterinary medicines by humans.This study aims to analyse Adverse Events (AEs) associated with selected veterinary productsusing the Food and Drug Administration Adverse Events Reporting System (FAERS). Methods: Adescriptive pharmacovigilance analysis was conducted on AEs related to 21 drugs approved forhuman and/or animal use. Results: A total of 38,756 AEs, including 9566 fatalities, were identified.The United States reported the highest number of cases (13,532), followed by Canada (2869) andthe United Kingdom (1400). Among the eight drugs licenced exclusively for animals, levamisole,pentobarbital, and xylazine were most frequently reported. Reports predominantly involved males(57%) from the 18–64 age group, with incidents related mainly to overdose, dependence, and multiagent toxicities. Unmasking techniques revealed ‘intentional overdose’ as the primary reaction.Polysubstance use was evident in 90% of the drugs, with benzodiazepines/Z-drugs and opioids ascommon co-used classes. Conclusions: Veterinary medications are increasingly infiltrating the illicitdrug market due to their pharmacological properties. This trend highlights the need for heightenedvigilance and awareness to prevent further public health risks associated with the adulteration ofillicit substances with veterinary products like xylazine and pentobarbital. Journal Article Toxics 12 11 777 MDPI AG 2305-6304 Veterinary medicines; animal medicines; substance use; pharmacovigilance; diversion of medicines; drug misuse 25 10 2024 2024-10-25 10.3390/toxics12110777 COLLEGE NANME COLLEGE CODE Swansea University Other This research received no external funding. 2024-12-12T16:03:43.5259121 2024-10-23T14:46:31.3457871 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Pharmacy JOSIE DUNN 1 Fabrizio Schifano 0000-0002-4178-5401 2 Ed Dudley 3 Amira Guirguis 0000-0001-8255-0660 4 68050__32888__b4018248d32d4915b518ec7e214bf3f6.pdf 68050.VOR.pdf 2024-11-07T15:10:16.1306913 Output 833090 application/pdf Version of Record true © 2024 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. true eng https://creativecommons.org/licenses/by/4.0/
title	Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)
spellingShingle	Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS) JOSIE DUNN Ed Dudley Amira Guirguis
title_short	Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)
title_full	Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)
title_fullStr	Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)
title_full_unstemmed	Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)
title_sort	Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)
author_id_str_mv	8f5a87c617b03551d21ea17a4f2083b4 c7d05f992a817cd3b9a5f946bd909b71 b49270b9a0d580cf4f31f9a1b6c93f87
author_id_fullname_str_mv	8f5a87c617b03551d21ea17a4f2083b4_*_JOSIE DUNN c7d05f992a817cd3b9a5f946bd909b71__Ed Dudley b49270b9a0d580cf4f31f9a1b6c93f87_**_Amira Guirguis
author	JOSIE DUNN Ed Dudley Amira Guirguis
author2	JOSIE DUNN Fabrizio Schifano Ed Dudley Amira Guirguis
format	Journal article
container_title	Toxics
container_volume	12
container_issue	11
container_start_page	777
publishDate	2024
institution	Swansea University
issn	2305-6304
doi_str_mv	10.3390/toxics12110777
publisher	MDPI AG
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Pharmacy{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Pharmacy
document_store_str	0
active_str	0
description	Introduction: Evidence suggests an increasing misuse of veterinary medicines by humans.This study aims to analyse Adverse Events (AEs) associated with selected veterinary productsusing the Food and Drug Administration Adverse Events Reporting System (FAERS). Methods: Adescriptive pharmacovigilance analysis was conducted on AEs related to 21 drugs approved forhuman and/or animal use. Results: A total of 38,756 AEs, including 9566 fatalities, were identified.The United States reported the highest number of cases (13,532), followed by Canada (2869) andthe United Kingdom (1400). Among the eight drugs licenced exclusively for animals, levamisole,pentobarbital, and xylazine were most frequently reported. Reports predominantly involved males(57%) from the 18–64 age group, with incidents related mainly to overdose, dependence, and multiagent toxicities. Unmasking techniques revealed ‘intentional overdose’ as the primary reaction.Polysubstance use was evident in 90% of the drugs, with benzodiazepines/Z-drugs and opioids ascommon co-used classes. Conclusions: Veterinary medications are increasingly infiltrating the illicitdrug market due to their pharmacological properties. This trend highlights the need for heightenedvigilance and awareness to prevent further public health risks associated with the adulteration ofillicit substances with veterinary products like xylazine and pentobarbital.
published_date	2024-10-25T05:47:52Z
_version_	1822108074677108736
score	11.363283

Exploring Human Misuse and Abuse of Veterinary Drugs: A Descriptive Pharmacovigilance Analysis Utilising the Food and Drug Administration’s Adverse Events Reporting System (FAERS)

Similar Items