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Residential green environments are associated with human milk oligosaccharide diversity and composition
Scientific Reports, Volume: 13, Issue: 1, Start page: 216
Swansea University Author:
Laura Galante
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© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.
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DOI (Published version): 10.1038/s41598-022-27317-1
Abstract
Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between prop...
Published in: | Scientific Reports |
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ISSN: | 2045-2322 |
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Springer Science and Business Media LLC
2023
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URI: | https://cronfa.swan.ac.uk/Record/cronfa68010 |
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We investigated the associations between properties of the mother’s residential green environment, measured as (1) greenness (Normalized Difference Vegetation index, NDVI), (2) Vegetation Cover Diversity (VCDI) and (3) Naturalness Index (NI), and human milk oligosaccharides (HMOs), known for their immune- and microbiota-related health effects on the infant (N = 795 mothers). We show that HMO diversity increases and concentrations of several individual HMOs and HMO groups change with increased VCDI and NI in residential green environments. This suggests that variation in residential green environments may influence the infant via maternal milk through modified HMO composition. The results emphasize the mediating role of breastfeeding between the residential green environments and health in early life.</abstract><type>Journal Article</type><journal>Scientific Reports</journal><volume>13</volume><journalNumber>1</journalNumber><paginationStart>216</paginationStart><paginationEnd/><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2045-2322</issnElectronic><keywords/><publishedDay>5</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2023</publishedYear><publishedDate>2023-01-05</publishedDate><doi>10.1038/s41598-022-27317-1</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>We would like to thank all the STEPS Study families who took part in the study and mothers who provided milk samples. 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2025-02-12T13:36:29.5078348 v2 68010 2024-10-18 Residential green environments are associated with human milk oligosaccharide diversity and composition d1c6c22f6a863ef2050ed9768566884b 0000-0002-6190-7955 Laura Galante Laura Galante true false 2024-10-18 MEDS Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between properties of the mother’s residential green environment, measured as (1) greenness (Normalized Difference Vegetation index, NDVI), (2) Vegetation Cover Diversity (VCDI) and (3) Naturalness Index (NI), and human milk oligosaccharides (HMOs), known for their immune- and microbiota-related health effects on the infant (N = 795 mothers). We show that HMO diversity increases and concentrations of several individual HMOs and HMO groups change with increased VCDI and NI in residential green environments. This suggests that variation in residential green environments may influence the infant via maternal milk through modified HMO composition. The results emphasize the mediating role of breastfeeding between the residential green environments and health in early life. Journal Article Scientific Reports 13 1 216 Springer Science and Business Media LLC 2045-2322 5 1 2023 2023-01-05 10.1038/s41598-022-27317-1 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee We would like to thank all the STEPS Study families who took part in the study and mothers who provided milk samples. We are grateful for all the research staff who assisted in the recruitment and data collection. We thank the National Institute of Health (R21-HD088953/L.B.) and the Academy of Finland (grant numbers 329240/J.V. and 321409/H.L.) for funding. Additional funding was received from the Strategic Research Council at the Academy of Finland (grant number 345183 and 345185/M.L.). 2025-02-12T13:36:29.5078348 2024-10-18T08:50:16.2008366 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Mirkka Lahdenperä 0000-0003-0062-6284 1 Laura Galante 0000-0002-6190-7955 2 Carlos Gonzales-Inca 0000-0003-0300-9097 3 Jussi Vahtera 0000-0002-6036-061x 4 Jaana Pentti 5 Samuli Rautava 0000-0003-0935-3593 6 Niina Käyhkö 0000-0003-2482-5085 7 Chloe Yonemitsu 8 Julia Gupta 9 Lars Bode 0000-0002-9914-9571 10 Hanna Lagström 0000-0002-5069-6582 11 68010__33194__28ff1e8a58da45ab952c2e25f89e216b.pdf 68010.VoR.pdf 2024-12-20T09:39:16.9082744 Output 1688292 application/pdf Version of Record true © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/ |
title |
Residential green environments are associated with human milk oligosaccharide diversity and composition |
spellingShingle |
Residential green environments are associated with human milk oligosaccharide diversity and composition Laura Galante |
title_short |
Residential green environments are associated with human milk oligosaccharide diversity and composition |
title_full |
Residential green environments are associated with human milk oligosaccharide diversity and composition |
title_fullStr |
Residential green environments are associated with human milk oligosaccharide diversity and composition |
title_full_unstemmed |
Residential green environments are associated with human milk oligosaccharide diversity and composition |
title_sort |
Residential green environments are associated with human milk oligosaccharide diversity and composition |
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d1c6c22f6a863ef2050ed9768566884b |
author_id_fullname_str_mv |
d1c6c22f6a863ef2050ed9768566884b_***_Laura Galante |
author |
Laura Galante |
author2 |
Mirkka Lahdenperä Laura Galante Carlos Gonzales-Inca Jussi Vahtera Jaana Pentti Samuli Rautava Niina Käyhkö Chloe Yonemitsu Julia Gupta Lars Bode Hanna Lagström |
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Scientific Reports |
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10.1038/s41598-022-27317-1 |
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Springer Science and Business Media LLC |
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Faculty of Medicine, Health and Life Sciences |
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Increased exposure to greener environments has been suggested to lead to health benefits in children, but the associated mechanisms in early life, particularly via biological mediators such as altered maternal milk composition, remain largely unexplored. We investigated the associations between properties of the mother’s residential green environment, measured as (1) greenness (Normalized Difference Vegetation index, NDVI), (2) Vegetation Cover Diversity (VCDI) and (3) Naturalness Index (NI), and human milk oligosaccharides (HMOs), known for their immune- and microbiota-related health effects on the infant (N = 795 mothers). We show that HMO diversity increases and concentrations of several individual HMOs and HMO groups change with increased VCDI and NI in residential green environments. This suggests that variation in residential green environments may influence the infant via maternal milk through modified HMO composition. The results emphasize the mediating role of breastfeeding between the residential green environments and health in early life. |
published_date |
2023-01-05T14:35:52Z |
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11.051735 |