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Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis

Graham Birch Orcid Logo, Magali Meniri, Chris Mitchell, Francis Mwanguhya, Robert Businge, Solomon Ahabyona, Hazel Nichols Orcid Logo, Michael A. Cant, Jonathan D. Blount

Antioxidants, Volume: 13, Issue: 9, Start page: 1124

Swansea University Author: Hazel Nichols Orcid Logo

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DOI (Published version): 10.3390/antiox13091124

Abstract

Reproductive activity is costly in terms of future reproduction and survival. Oxidative stress has been identified as a likely mechanism underlying this cost of reproduction. However, empirical studies have yielded the paradoxical observation that breeders often sustain lower levels of oxidative dam...

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Published in: Antioxidants
ISSN: 2076-3921
Published: MDPI AG 2024
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URI: https://cronfa.swan.ac.uk/Record/cronfa67711
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However, empirical studies have yielded the paradoxical observation that breeders often sustain lower levels of oxidative damage than non-breeders. The oxidative shielding hypothesis attempts to explain such data, and posits that breeders pre-emptively reduce levels of oxidative damage in order to protect their germ cells, and any resultant offspring, from harm caused by exposure to oxidative damage. While there is some empirical evidence of oxidative shielding in females, there have been no explicit tests of this hypothesis in males, despite evidence of the oxidative costs to the male reproductive effort and the vulnerability of sperm cells to oxidative damage. In this study, we assess lipid oxidative damage (malondialdehyde, MDA) in the ejaculates of reproducing and non-reproducing wild banded mongooses. We found that, among breeding males, ejaculate MDA levels were lower during mate competition compared to 2 months later, when individuals were not mating, which is consistent with the oxidative shielding hypothesis, and similar to findings in females. However, ejaculate MDA levels did not differ significantly between breeding and non-breeding individuals at the time of mating, contrary to expectation. The finding that ejaculate MDA was not higher in non-breeders may reflect individual differences in quality and hence oxidative stress. In particular, breeders were significantly older than non-breeders, which may obscure differences in oxidative damage due to reproductive investment. 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spelling v2 67711 2024-09-18 Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis 43ba12986bd7754484874c73eed0ebfe 0000-0002-4455-6065 Hazel Nichols Hazel Nichols true false 2024-09-18 BGPS Reproductive activity is costly in terms of future reproduction and survival. Oxidative stress has been identified as a likely mechanism underlying this cost of reproduction. However, empirical studies have yielded the paradoxical observation that breeders often sustain lower levels of oxidative damage than non-breeders. The oxidative shielding hypothesis attempts to explain such data, and posits that breeders pre-emptively reduce levels of oxidative damage in order to protect their germ cells, and any resultant offspring, from harm caused by exposure to oxidative damage. While there is some empirical evidence of oxidative shielding in females, there have been no explicit tests of this hypothesis in males, despite evidence of the oxidative costs to the male reproductive effort and the vulnerability of sperm cells to oxidative damage. In this study, we assess lipid oxidative damage (malondialdehyde, MDA) in the ejaculates of reproducing and non-reproducing wild banded mongooses. We found that, among breeding males, ejaculate MDA levels were lower during mate competition compared to 2 months later, when individuals were not mating, which is consistent with the oxidative shielding hypothesis, and similar to findings in females. However, ejaculate MDA levels did not differ significantly between breeding and non-breeding individuals at the time of mating, contrary to expectation. The finding that ejaculate MDA was not higher in non-breeders may reflect individual differences in quality and hence oxidative stress. In particular, breeders were significantly older than non-breeders, which may obscure differences in oxidative damage due to reproductive investment. Further research is needed to establish the causal relationship between reproductive investment and oxidative damage in ejaculates, and the consequences for offspring development in banded mongooses and other species. Journal Article Antioxidants 13 9 1124 MDPI AG 2076-3921 cooperative breeder; intergenerational effects; life-history; oxidative stress; reproductive costs 18 9 2024 2024-09-18 10.3390/antiox13091124 COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University Another institution paid the OA fee G.B. received funding from NERC GW4+ (studentship no. NE/S007504/1). Data collection has been funded by an ERC Starting Grant (SOCODEV, grant number 309249) and NERC (UK) Standard Grants (NE/E015441/1; NE/J010278/1) awarded to M.A.C., and NE/N011171 awarded to J.D.B. and M.A.C. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. 2024-10-24T10:48:57.5600628 2024-09-18T10:47:43.3319243 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Graham Birch 0000-0002-7412-4095 1 Magali Meniri 2 Chris Mitchell 3 Francis Mwanguhya 4 Robert Businge 5 Solomon Ahabyona 6 Hazel Nichols 0000-0002-4455-6065 7 Michael A. Cant 8 Jonathan D. Blount 9 67711__31537__552f37a8c179496f99896281880ca7b8.pdf antioxidants-13-01124.pdf 2024-10-04T11:11:31.6161924 Output 744191 application/pdf Version of Record true © 2024 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. true eng https://creativecommons.org/licenses/by/4.0/
title Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis
spellingShingle Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis
Hazel Nichols
title_short Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis
title_full Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis
title_fullStr Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis
title_full_unstemmed Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis
title_sort Variation in Lipid Peroxidation in the Ejaculates of Wild Banded Mongooses (Mungos mungo): A Test of the Oxidative Shielding Hypothesis
author_id_str_mv 43ba12986bd7754484874c73eed0ebfe
author_id_fullname_str_mv 43ba12986bd7754484874c73eed0ebfe_***_Hazel Nichols
author Hazel Nichols
author2 Graham Birch
Magali Meniri
Chris Mitchell
Francis Mwanguhya
Robert Businge
Solomon Ahabyona
Hazel Nichols
Michael A. Cant
Jonathan D. Blount
format Journal article
container_title Antioxidants
container_volume 13
container_issue 9
container_start_page 1124
publishDate 2024
institution Swansea University
issn 2076-3921
doi_str_mv 10.3390/antiox13091124
publisher MDPI AG
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description Reproductive activity is costly in terms of future reproduction and survival. Oxidative stress has been identified as a likely mechanism underlying this cost of reproduction. However, empirical studies have yielded the paradoxical observation that breeders often sustain lower levels of oxidative damage than non-breeders. The oxidative shielding hypothesis attempts to explain such data, and posits that breeders pre-emptively reduce levels of oxidative damage in order to protect their germ cells, and any resultant offspring, from harm caused by exposure to oxidative damage. While there is some empirical evidence of oxidative shielding in females, there have been no explicit tests of this hypothesis in males, despite evidence of the oxidative costs to the male reproductive effort and the vulnerability of sperm cells to oxidative damage. In this study, we assess lipid oxidative damage (malondialdehyde, MDA) in the ejaculates of reproducing and non-reproducing wild banded mongooses. We found that, among breeding males, ejaculate MDA levels were lower during mate competition compared to 2 months later, when individuals were not mating, which is consistent with the oxidative shielding hypothesis, and similar to findings in females. However, ejaculate MDA levels did not differ significantly between breeding and non-breeding individuals at the time of mating, contrary to expectation. The finding that ejaculate MDA was not higher in non-breeders may reflect individual differences in quality and hence oxidative stress. In particular, breeders were significantly older than non-breeders, which may obscure differences in oxidative damage due to reproductive investment. Further research is needed to establish the causal relationship between reproductive investment and oxidative damage in ejaculates, and the consequences for offspring development in banded mongooses and other species.
published_date 2024-09-18T10:48:56Z
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