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Defining an ageing-related pathology, disease or syndrome: International Consensus Statement

Emma Short Orcid Logo, (ICCARP), Stuart Calimport Orcid Logo, Barry Bentley Orcid Logo, Ian M. Adcock, Bilal Al-Sarireh, Ann Ager, Ramzi Ajjan, Naveed Akbar, Michael A. Akeroyd, Ghada Alsaleh, Ghada Al-Sharbatee, Kambiz Alavian, Winfried Amoaku, Julie Andersen, Chrystalina Antoniades, Mark J. Arends, Sue Astley, Denize Atan, Richard Attanoos, Johannes Attems, Steve Bain Orcid Logo, Konstantinos Balaskas, Gabriel Balmus, Manohar Bance, Thomas M. Barber, Ajoy Bardhan, Karen Barker, Peter Barnes, Gemma Basatemur, Adrian Bateman, Moises Evandro Bauer, Christopher Bellamy, Edwin van Beek, Ilaria Bellantuono, Emyr Benbow, Sunil Bhandari, Rahul Bhatnagar, Philip Bloom, Dawn Bowdish, Melissa Bowerman, Melanie Burke, Roxana Carare, Emma Victoria Carrington, Jorge Iván Castillo-Quan, Peter Clegg, James Cole, Carlo Cota, Paul Chazot, Christopher Chen, Ying Cheong, Gary Christopher Orcid Logo, George Church, David Clancy, Paul Cool, Del Galdo, Mayank Dalakoti, Soumit Dasgupta, Colleen Deane, Devesh Dhasmana, Stefan Dojcinov, Monia Di Prete, Huaidong Du, Niharika A. Duggal, Toby Ellmers, Costanza Emanueli, Mark Emberton, Jorge D. Erusalimsky, Laurence Feldmeyer, Alexander Fleming, Karen Forbes, Thomas C. Foster, Daniela Frasca, Ian Frayling, Daniel Freedman, Tamas Fülöp, Georgina Ellison-Hughes, Gus Gazzard, Christopher George Orcid Logo, Jesus Gil, Richard Glassock, Rob Goldin, John Green, Robyn Guymer, Hasan Haboubi Orcid Logo, Lorna Harries, Simon Hart, Douglas Hartley, Sebri Hasaballa, Christin Henein, Maggie Helliwell, Emily Henderson, Rakesh Heer, Kristofer Holte, Iskander Idris, David Isenburg, Juulia Jylhävä, Ahmed Iqbal, Simon W. Jones, Rajesh Kalaria, Venkat Kanamarlapudi Orcid Logo, Werner Kempf, Alexandra J. Kermack, Jemma Kerns, Albert Koulman, Adnan H. Khan, James Kinross, Katarina Klaucane, Yamini Krishna, Harinderjit Singh Gill, Edward Lakatta, Ezio Laconi, Alpar Lazar, Christiaan Leeuwenburgh, Samantha Leung, Xuan Li, Ian van der Linde, Luísa V. Lopes, Antonello Lorenzini, Andrew Lotery, Pedro Machado, Sarah Mackie, Paolo Madeddu, Andrea Maier, Krishna Mukkanna, Pinelopi Manousou, Oonagh Markey, Claudio Mauro, Barry McDonnell, Reinhold J. Medina, Soma Meran, Claudia Metzler-Baddeley, Ignor Meglinksi, Neta Milman, Christina Mitteldorf, Ruth Montgomery, Andrew Conway Morris, Beda Mühleisen, Abhik Mukherkee, Andrew Murray, Scott Nelson, Anna Nicolaou, Alexander Nirenberg, Simon Noble, Lisa S. Nolan, Meritxell Nus, Canh Van On, Victor Osei-Lah, Mandy Peffers, Antony Palmer, Donald Palmer, Laura Palmer, William Parry-Smith, Graham Pawelec, Shahaf Peleg, Ranmith Perera, Andrew Pitsillides, Christopher J. Plack, Franze Progatzsky, Sonja Pyott, Kaukab Rajput, Sameera Rashid, J. Arjuna Ratnayaka, Sudhira A. B. Ratnayake, Manuel Rodriguez-Justo, Arianna Carolina Rosa, Andrew Rule, Gareth J. Sanger, Ian Sayers, Andrew Saykin, Dinesh Selvarajah, Jaswinder Sethi, Cathy Shanahan, Shai Shen-Orr, Carl Sheridan, Paul Shiels, Kastytis Sidlauskas, Sobha Sivaprasad, Judith Sluimer, Gary Small, Peter Smith, Rebecca Smith, Sarah Snelling, Ioakim Spyridopoulos, Ramasamy Srinivasa Raghavan, David Steel, Karen P. Steel, Claire Stewart, Keeron Stone, Selvarani Subbarayan, Mark Sussman, Jonas Svensson, Vyshnavi Tadanki, Ai Lyn Tan, Rudolph E. Tanzi, Amanda Tatler, Adriana A. S. Tavares, Tengku Amatullah Madeehah Tengku Mohd, Ana Tiganescu, James Timmons, Jeremy Tree Orcid Logo, Drupad Trivedi, Emmanuel A. Tsochatzis, Dialechti Tsimpida, Elisabeth J. Vinke, Anna Whittaker, Neeru A. Vallabh, Kristin Veighey, Zoe C. Venables, Reddy Venkat, Meike W. Vernooij, Chris Verschoor, Manlio Vinciguerra, Vesna Vukanovic, Vladyslav Vyazovskiy, James Walker, Richard Wakefield, Adam J. Watkins, Anthony Webster, Caroline Weight, Birgit Weinberger, Susan L. Whitney, Rosalind Willis, Jacek M. Witkowski, Leonard L. L. Yeo, Tham Yhi Chung, Emma Yu, Michael Zemel

GeroScience, Volume: 47, Issue: 2, Pages: 1713 - 1720

Swansea University Authors: Steve Bain Orcid Logo, Gary Christopher Orcid Logo, Christopher George Orcid Logo, Hasan Haboubi Orcid Logo, Venkat Kanamarlapudi Orcid Logo, Jeremy Tree Orcid Logo

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DOI (Published version): 10.1007/s11357-024-01315-9

Abstract

Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It i...

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Published in: GeroScience
ISSN: 2509-2723
Published: Springer Science and Business Media LLC 2025
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa67686
first_indexed 2024-09-13T13:09:01Z
last_indexed 2025-04-12T04:32:35Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2025-04-11T13:07:34.8079644</datestamp><bib-version>v2</bib-version><id>67686</id><entry>2024-09-13</entry><title>Defining an ageing-related pathology, disease or syndrome: International Consensus Statement</title><swanseaauthors><author><sid>5399f4c6e6a70f3608a084ddb938511a</sid><ORCID>0000-0001-8519-4964</ORCID><firstname>Steve</firstname><surname>Bain</surname><name>Steve Bain</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>8092562c67809dfda89f7bb8582874d3</sid><ORCID>0000-0002-7175-6644</ORCID><firstname>Gary</firstname><surname>Christopher</surname><name>Gary Christopher</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>a2e211f7bd379c81e9c393637803a0a0</sid><ORCID>0000-0001-9852-1135</ORCID><firstname>Christopher</firstname><surname>George</surname><name>Christopher George</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>f64fa85e00cad9a1523513becac836e0</sid><ORCID>0000-0001-7324-7889</ORCID><firstname>Hasan</firstname><surname>Haboubi</surname><name>Hasan Haboubi</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>63741801137148abfa4c00cd547dcdfa</sid><ORCID>0000-0002-8739-1483</ORCID><firstname>Venkat</firstname><surname>Kanamarlapudi</surname><name>Venkat Kanamarlapudi</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>373fd575114a743d502a979c6161b1ad</sid><ORCID>0000-0001-6000-8125</ORCID><firstname>Jeremy</firstname><surname>Tree</surname><name>Jeremy Tree</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2024-09-13</date><deptcode>MEDS</deptcode><abstract>Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndromes. This will allow societies to better identify, quantify, understand and meet the healthcare, workforce, well-being and socioeconomic needs of ageing populations, whilst supporting the development and utilisation of interventions to prevent or to slow, halt or reverse the progression of ageing-related pathologies. The foundation for developing such classification and staging systems is to define the scope of what constitutes an ageing-related pathology, disease or syndrome. To this end, a consensus meeting was hosted by the International Consortium to Classify Ageing-Related Pathologies (ICCARP), on February 19, 2024, in Cardiff, UK, and was attended by 150 recognised experts. Discussions and voting were centred on provisional criteria that had been distributed prior to the meeting. The participants debated and voted on these. Each criterion required a consensus agreement of&#x2009;&#x2265;&#x2009;70% for approval. The accepted criteria for an ageing-related pathology, disease or syndrome were (1) develops and/or progresses with increasing chronological age; (2) should be associated with, or contribute to, functional decline or an increased susceptibility to functional decline and (3) evidenced by studies in humans. Criteria for an ageing-related pathology, disease or syndrome have been agreed by an international consortium of subject experts. These criteria will now be used by the ICCARP for the classification and ultimately staging of ageing-related pathologies, diseases and syndromes.</abstract><type>Journal Article</type><journal>GeroScience</journal><volume>47</volume><journalNumber>2</journalNumber><paginationStart>1713</paginationStart><paginationEnd>1720</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2509-2723</issnElectronic><keywords>Ageing-related pathology; Disease; Syndrome; Ageing; Longevity</keywords><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2025</publishedYear><publishedDate>2025-04-01</publishedDate><doi>10.1007/s11357-024-01315-9</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>This project was supported by a Longevity Impetus Grant from Norn Group.</funders><projectreference/><lastEdited>2025-04-11T13:07:34.8079644</lastEdited><Created>2024-09-13T14:03:26.0437702</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Biomedical Science</level></path><authors><author><firstname>Emma</firstname><surname>Short</surname><orcid>0000-0001-5050-589x</orcid><order>1</order></author><author><firstname></firstname><surname>(ICCARP)</surname><order>2</order></author><author><firstname>Stuart</firstname><surname>Calimport</surname><orcid>0000-0002-0085-0385</orcid><order>3</order></author><author><firstname>Barry</firstname><surname>Bentley</surname><orcid>0000-0002-4360-5902</orcid><order>4</order></author><author><firstname>Ian M.</firstname><surname>Adcock</surname><order>5</order></author><author><firstname>Bilal</firstname><surname>Al-Sarireh</surname><order>6</order></author><author><firstname>Ann</firstname><surname>Ager</surname><order>7</order></author><author><firstname>Ramzi</firstname><surname>Ajjan</surname><order>8</order></author><author><firstname>Naveed</firstname><surname>Akbar</surname><order>9</order></author><author><firstname>Michael A.</firstname><surname>Akeroyd</surname><order>10</order></author><author><firstname>Ghada</firstname><surname>Alsaleh</surname><order>11</order></author><author><firstname>Ghada</firstname><surname>Al-Sharbatee</surname><order>12</order></author><author><firstname>Kambiz</firstname><surname>Alavian</surname><order>13</order></author><author><firstname>Winfried</firstname><surname>Amoaku</surname><order>14</order></author><author><firstname>Julie</firstname><surname>Andersen</surname><order>15</order></author><author><firstname>Chrystalina</firstname><surname>Antoniades</surname><order>16</order></author><author><firstname>Mark 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M.</firstname><surname>Barber</surname><order>26</order></author><author><firstname>Ajoy</firstname><surname>Bardhan</surname><order>27</order></author><author><firstname>Karen</firstname><surname>Barker</surname><order>28</order></author><author><firstname>Peter</firstname><surname>Barnes</surname><order>29</order></author><author><firstname>Gemma</firstname><surname>Basatemur</surname><order>30</order></author><author><firstname>Adrian</firstname><surname>Bateman</surname><order>31</order></author><author><firstname>Moises Evandro</firstname><surname>Bauer</surname><order>32</order></author><author><firstname>Christopher</firstname><surname>Bellamy</surname><order>33</order></author><author><firstname>Edwin 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V.</firstname><surname>Lopes</surname><order>118</order></author><author><firstname>Antonello</firstname><surname>Lorenzini</surname><order>119</order></author><author><firstname>Andrew</firstname><surname>Lotery</surname><order>120</order></author><author><firstname>Pedro</firstname><surname>Machado</surname><order>121</order></author><author><firstname>Sarah</firstname><surname>Mackie</surname><order>122</order></author><author><firstname>Paolo</firstname><surname>Madeddu</surname><order>123</order></author><author><firstname>Andrea</firstname><surname>Maier</surname><order>124</order></author><author><firstname>Krishna</firstname><surname>Mukkanna</surname><order>125</order></author><author><firstname>Pinelopi</firstname><surname>Manousou</surname><order>126</order></author><author><firstname>Oonagh</firstname><surname>Markey</surname><order>127</order></author><author><firstname>Claudio</firstname><surname>Mauro</surname><order>128</order></author><author><firstname>Barry</firstname><surname>McDonnell</surname><order>129</order></author><author><firstname>Reinhold 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Conway</firstname><surname>Morris</surname><order>137</order></author><author><firstname>Beda</firstname><surname>M&#xFC;hleisen</surname><order>138</order></author><author><firstname>Abhik</firstname><surname>Mukherkee</surname><order>139</order></author><author><firstname>Andrew</firstname><surname>Murray</surname><order>140</order></author><author><firstname>Scott</firstname><surname>Nelson</surname><order>141</order></author><author><firstname>Anna</firstname><surname>Nicolaou</surname><order>142</order></author><author><firstname>Alexander</firstname><surname>Nirenberg</surname><order>143</order></author><author><firstname>Simon</firstname><surname>Noble</surname><order>144</order></author><author><firstname>Lisa S.</firstname><surname>Nolan</surname><order>145</order></author><author><firstname>Meritxell</firstname><surname>Nus</surname><order>146</order></author><author><firstname>Canh Van</firstname><surname>On</surname><order>147</order></author><author><firstname>Victor</firstname><surname>Osei-Lah</surname><order>148</order></author><author><firstname>Mandy</firstname><surname>Peffers</surname><order>149</order></author><author><firstname>Antony</firstname><surname>Palmer</surname><order>150</order></author><author><firstname>Donald</firstname><surname>Palmer</surname><order>151</order></author><author><firstname>Laura</firstname><surname>Palmer</surname><order>152</order></author><author><firstname>William</firstname><surname>Parry-Smith</surname><order>153</order></author><author><firstname>Graham</firstname><surname>Pawelec</surname><order>154</order></author><author><firstname>Shahaf</firstname><surname>Peleg</surname><order>155</order></author><author><firstname>Ranmith</firstname><surname>Perera</surname><order>156</order></author><author><firstname>Andrew</firstname><surname>Pitsillides</surname><order>157</order></author><author><firstname>Christopher J.</firstname><surname>Plack</surname><order>158</order></author><author><firstname>Franze</firstname><surname>Progatzsky</surname><order>159</order></author><author><firstname>Sonja</firstname><surname>Pyott</surname><order>160</order></author><author><firstname>Kaukab</firstname><surname>Rajput</surname><order>161</order></author><author><firstname>Sameera</firstname><surname>Rashid</surname><order>162</order></author><author><firstname>J. Arjuna</firstname><surname>Ratnayaka</surname><order>163</order></author><author><firstname>Sudhira A. B.</firstname><surname>Ratnayake</surname><order>164</order></author><author><firstname>Manuel</firstname><surname>Rodriguez-Justo</surname><order>165</order></author><author><firstname>Arianna Carolina</firstname><surname>Rosa</surname><order>166</order></author><author><firstname>Andrew</firstname><surname>Rule</surname><order>167</order></author><author><firstname>Gareth J.</firstname><surname>Sanger</surname><order>168</order></author><author><firstname>Ian</firstname><surname>Sayers</surname><order>169</order></author><author><firstname>Andrew</firstname><surname>Saykin</surname><order>170</order></author><author><firstname>Dinesh</firstname><surname>Selvarajah</surname><order>171</order></author><author><firstname>Jaswinder</firstname><surname>Sethi</surname><order>172</order></author><author><firstname>Cathy</firstname><surname>Shanahan</surname><order>173</order></author><author><firstname>Shai</firstname><surname>Shen-Orr</surname><order>174</order></author><author><firstname>Carl</firstname><surname>Sheridan</surname><order>175</order></author><author><firstname>Paul</firstname><surname>Shiels</surname><order>176</order></author><author><firstname>Kastytis</firstname><surname>Sidlauskas</surname><order>177</order></author><author><firstname>Sobha</firstname><surname>Sivaprasad</surname><order>178</order></author><author><firstname>Judith</firstname><surname>Sluimer</surname><order>179</order></author><author><firstname>Gary</firstname><surname>Small</surname><order>180</order></author><author><firstname>Peter</firstname><surname>Smith</surname><order>181</order></author><author><firstname>Rebecca</firstname><surname>Smith</surname><order>182</order></author><author><firstname>Sarah</firstname><surname>Snelling</surname><order>183</order></author><author><firstname>Ioakim</firstname><surname>Spyridopoulos</surname><order>184</order></author><author><firstname>Ramasamy Srinivasa</firstname><surname>Raghavan</surname><order>185</order></author><author><firstname>David</firstname><surname>Steel</surname><order>186</order></author><author><firstname>Karen P.</firstname><surname>Steel</surname><order>187</order></author><author><firstname>Claire</firstname><surname>Stewart</surname><order>188</order></author><author><firstname>Keeron</firstname><surname>Stone</surname><order>189</order></author><author><firstname>Selvarani</firstname><surname>Subbarayan</surname><order>190</order></author><author><firstname>Mark</firstname><surname>Sussman</surname><order>191</order></author><author><firstname>Jonas</firstname><surname>Svensson</surname><order>192</order></author><author><firstname>Vyshnavi</firstname><surname>Tadanki</surname><order>193</order></author><author><firstname>Ai Lyn</firstname><surname>Tan</surname><order>194</order></author><author><firstname>Rudolph E.</firstname><surname>Tanzi</surname><order>195</order></author><author><firstname>Amanda</firstname><surname>Tatler</surname><order>196</order></author><author><firstname>Adriana A. S.</firstname><surname>Tavares</surname><order>197</order></author><author><firstname>Tengku Amatullah Madeehah Tengku</firstname><surname>Mohd</surname><order>198</order></author><author><firstname>Ana</firstname><surname>Tiganescu</surname><order>199</order></author><author><firstname>James</firstname><surname>Timmons</surname><order>200</order></author><author><firstname>Jeremy</firstname><surname>Tree</surname><orcid>0000-0001-6000-8125</orcid><order>201</order></author><author><firstname>Drupad</firstname><surname>Trivedi</surname><order>202</order></author><author><firstname>Emmanuel A.</firstname><surname>Tsochatzis</surname><order>203</order></author><author><firstname>Dialechti</firstname><surname>Tsimpida</surname><order>204</order></author><author><firstname>Elisabeth J.</firstname><surname>Vinke</surname><order>205</order></author><author><firstname>Anna</firstname><surname>Whittaker</surname><order>206</order></author><author><firstname>Neeru A.</firstname><surname>Vallabh</surname><order>207</order></author><author><firstname>Kristin</firstname><surname>Veighey</surname><order>208</order></author><author><firstname>Zoe C.</firstname><surname>Venables</surname><order>209</order></author><author><firstname>Reddy</firstname><surname>Venkat</surname><order>210</order></author><author><firstname>Meike W.</firstname><surname>Vernooij</surname><order>211</order></author><author><firstname>Chris</firstname><surname>Verschoor</surname><order>212</order></author><author><firstname>Manlio</firstname><surname>Vinciguerra</surname><order>213</order></author><author><firstname>Vesna</firstname><surname>Vukanovic</surname><order>214</order></author><author><firstname>Vladyslav</firstname><surname>Vyazovskiy</surname><order>215</order></author><author><firstname>James</firstname><surname>Walker</surname><order>216</order></author><author><firstname>Richard</firstname><surname>Wakefield</surname><order>217</order></author><author><firstname>Adam J.</firstname><surname>Watkins</surname><order>218</order></author><author><firstname>Anthony</firstname><surname>Webster</surname><order>219</order></author><author><firstname>Caroline</firstname><surname>Weight</surname><order>220</order></author><author><firstname>Birgit</firstname><surname>Weinberger</surname><order>221</order></author><author><firstname>Susan L.</firstname><surname>Whitney</surname><order>222</order></author><author><firstname>Rosalind</firstname><surname>Willis</surname><order>223</order></author><author><firstname>Jacek M.</firstname><surname>Witkowski</surname><order>224</order></author><author><firstname>Leonard L. 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spelling 2025-04-11T13:07:34.8079644 v2 67686 2024-09-13 Defining an ageing-related pathology, disease or syndrome: International Consensus Statement 5399f4c6e6a70f3608a084ddb938511a 0000-0001-8519-4964 Steve Bain Steve Bain true false 8092562c67809dfda89f7bb8582874d3 0000-0002-7175-6644 Gary Christopher Gary Christopher true false a2e211f7bd379c81e9c393637803a0a0 0000-0001-9852-1135 Christopher George Christopher George true false f64fa85e00cad9a1523513becac836e0 0000-0001-7324-7889 Hasan Haboubi Hasan Haboubi true false 63741801137148abfa4c00cd547dcdfa 0000-0002-8739-1483 Venkat Kanamarlapudi Venkat Kanamarlapudi true false 373fd575114a743d502a979c6161b1ad 0000-0001-6000-8125 Jeremy Tree Jeremy Tree true false 2024-09-13 MEDS Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndromes. This will allow societies to better identify, quantify, understand and meet the healthcare, workforce, well-being and socioeconomic needs of ageing populations, whilst supporting the development and utilisation of interventions to prevent or to slow, halt or reverse the progression of ageing-related pathologies. The foundation for developing such classification and staging systems is to define the scope of what constitutes an ageing-related pathology, disease or syndrome. To this end, a consensus meeting was hosted by the International Consortium to Classify Ageing-Related Pathologies (ICCARP), on February 19, 2024, in Cardiff, UK, and was attended by 150 recognised experts. Discussions and voting were centred on provisional criteria that had been distributed prior to the meeting. The participants debated and voted on these. Each criterion required a consensus agreement of ≥ 70% for approval. The accepted criteria for an ageing-related pathology, disease or syndrome were (1) develops and/or progresses with increasing chronological age; (2) should be associated with, or contribute to, functional decline or an increased susceptibility to functional decline and (3) evidenced by studies in humans. Criteria for an ageing-related pathology, disease or syndrome have been agreed by an international consortium of subject experts. These criteria will now be used by the ICCARP for the classification and ultimately staging of ageing-related pathologies, diseases and syndromes. Journal Article GeroScience 47 2 1713 1720 Springer Science and Business Media LLC 2509-2723 Ageing-related pathology; Disease; Syndrome; Ageing; Longevity 1 4 2025 2025-04-01 10.1007/s11357-024-01315-9 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee This project was supported by a Longevity Impetus Grant from Norn Group. 2025-04-11T13:07:34.8079644 2024-09-13T14:03:26.0437702 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Emma Short 0000-0001-5050-589x 1 (ICCARP) 2 Stuart Calimport 0000-0002-0085-0385 3 Barry Bentley 0000-0002-4360-5902 4 Ian M. Adcock 5 Bilal Al-Sarireh 6 Ann Ager 7 Ramzi Ajjan 8 Naveed Akbar 9 Michael A. Akeroyd 10 Ghada Alsaleh 11 Ghada Al-Sharbatee 12 Kambiz Alavian 13 Winfried Amoaku 14 Julie Andersen 15 Chrystalina Antoniades 16 Mark J. Arends 17 Sue Astley 18 Denize Atan 19 Richard Attanoos 20 Johannes Attems 21 Steve Bain 0000-0001-8519-4964 22 Konstantinos Balaskas 23 Gabriel Balmus 24 Manohar Bance 25 Thomas M. Barber 26 Ajoy Bardhan 27 Karen Barker 28 Peter Barnes 29 Gemma Basatemur 30 Adrian Bateman 31 Moises Evandro Bauer 32 Christopher Bellamy 33 Edwin van Beek 34 Ilaria Bellantuono 35 Emyr Benbow 36 Sunil Bhandari 37 Rahul Bhatnagar 38 Philip Bloom 39 Dawn Bowdish 40 Melissa Bowerman 41 Melanie Burke 42 Roxana Carare 43 Emma Victoria Carrington 44 Jorge Iván Castillo-Quan 45 Peter Clegg 46 James Cole 47 Carlo Cota 48 Paul Chazot 49 Christopher Chen 50 Ying Cheong 51 Gary Christopher 0000-0002-7175-6644 52 George Church 53 David Clancy 54 Paul Cool 55 Del Galdo 56 Mayank Dalakoti 57 Soumit Dasgupta 58 Colleen Deane 59 Devesh Dhasmana 60 Stefan Dojcinov 61 Monia Di Prete 62 Huaidong Du 63 Niharika A. Duggal 64 Toby Ellmers 65 Costanza Emanueli 66 Mark Emberton 67 Jorge D. Erusalimsky 68 Laurence Feldmeyer 69 Alexander Fleming 70 Karen Forbes 71 Thomas C. Foster 72 Daniela Frasca 73 Ian Frayling 74 Daniel Freedman 75 Tamas Fülöp 76 Georgina Ellison-Hughes 77 Gus Gazzard 78 Christopher George 0000-0001-9852-1135 79 Jesus Gil 80 Richard Glassock 81 Rob Goldin 82 John Green 83 Robyn Guymer 84 Hasan Haboubi 0000-0001-7324-7889 85 Lorna Harries 86 Simon Hart 87 Douglas Hartley 88 Sebri Hasaballa 89 Christin Henein 90 Maggie Helliwell 91 Emily Henderson 92 Rakesh Heer 93 Kristofer Holte 94 Iskander Idris 95 David Isenburg 96 Juulia Jylhävä 97 Ahmed Iqbal 98 Simon W. Jones 99 Rajesh Kalaria 100 Venkat Kanamarlapudi 0000-0002-8739-1483 101 Werner Kempf 102 Alexandra J. Kermack 103 Jemma Kerns 104 Albert Koulman 105 Adnan H. Khan 106 James Kinross 107 Katarina Klaucane 108 Yamini Krishna 109 Harinderjit Singh Gill 110 Edward Lakatta 111 Ezio Laconi 112 Alpar Lazar 113 Christiaan Leeuwenburgh 114 Samantha Leung 115 Xuan Li 116 Ian van der Linde 117 Luísa V. Lopes 118 Antonello Lorenzini 119 Andrew Lotery 120 Pedro Machado 121 Sarah Mackie 122 Paolo Madeddu 123 Andrea Maier 124 Krishna Mukkanna 125 Pinelopi Manousou 126 Oonagh Markey 127 Claudio Mauro 128 Barry McDonnell 129 Reinhold J. Medina 130 Soma Meran 131 Claudia Metzler-Baddeley 132 Ignor Meglinksi 133 Neta Milman 134 Christina Mitteldorf 135 Ruth Montgomery 136 Andrew Conway Morris 137 Beda Mühleisen 138 Abhik Mukherkee 139 Andrew Murray 140 Scott Nelson 141 Anna Nicolaou 142 Alexander Nirenberg 143 Simon Noble 144 Lisa S. Nolan 145 Meritxell Nus 146 Canh Van On 147 Victor Osei-Lah 148 Mandy Peffers 149 Antony Palmer 150 Donald Palmer 151 Laura Palmer 152 William Parry-Smith 153 Graham Pawelec 154 Shahaf Peleg 155 Ranmith Perera 156 Andrew Pitsillides 157 Christopher J. Plack 158 Franze Progatzsky 159 Sonja Pyott 160 Kaukab Rajput 161 Sameera Rashid 162 J. Arjuna Ratnayaka 163 Sudhira A. B. Ratnayake 164 Manuel Rodriguez-Justo 165 Arianna Carolina Rosa 166 Andrew Rule 167 Gareth J. Sanger 168 Ian Sayers 169 Andrew Saykin 170 Dinesh Selvarajah 171 Jaswinder Sethi 172 Cathy Shanahan 173 Shai Shen-Orr 174 Carl Sheridan 175 Paul Shiels 176 Kastytis Sidlauskas 177 Sobha Sivaprasad 178 Judith Sluimer 179 Gary Small 180 Peter Smith 181 Rebecca Smith 182 Sarah Snelling 183 Ioakim Spyridopoulos 184 Ramasamy Srinivasa Raghavan 185 David Steel 186 Karen P. Steel 187 Claire Stewart 188 Keeron Stone 189 Selvarani Subbarayan 190 Mark Sussman 191 Jonas Svensson 192 Vyshnavi Tadanki 193 Ai Lyn Tan 194 Rudolph E. Tanzi 195 Amanda Tatler 196 Adriana A. S. Tavares 197 Tengku Amatullah Madeehah Tengku Mohd 198 Ana Tiganescu 199 James Timmons 200 Jeremy Tree 0000-0001-6000-8125 201 Drupad Trivedi 202 Emmanuel A. Tsochatzis 203 Dialechti Tsimpida 204 Elisabeth J. Vinke 205 Anna Whittaker 206 Neeru A. Vallabh 207 Kristin Veighey 208 Zoe C. Venables 209 Reddy Venkat 210 Meike W. Vernooij 211 Chris Verschoor 212 Manlio Vinciguerra 213 Vesna Vukanovic 214 Vladyslav Vyazovskiy 215 James Walker 216 Richard Wakefield 217 Adam J. Watkins 218 Anthony Webster 219 Caroline Weight 220 Birgit Weinberger 221 Susan L. Whitney 222 Rosalind Willis 223 Jacek M. Witkowski 224 Leonard L. L. Yeo 225 Tham Yhi Chung 226 Emma Yu 227 Michael Zemel 228 67686__32814__bf0a513ea5f74122aec726afe442aacf.pdf 67686.VoR.pdf 2024-11-01T11:37:47.8870824 Output 551519 application/pdf Version of Record true © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
spellingShingle Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
Steve Bain
Gary Christopher
Christopher George
Hasan Haboubi
Venkat Kanamarlapudi
Jeremy Tree
title_short Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
title_full Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
title_fullStr Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
title_full_unstemmed Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
title_sort Defining an ageing-related pathology, disease or syndrome: International Consensus Statement
author_id_str_mv 5399f4c6e6a70f3608a084ddb938511a
8092562c67809dfda89f7bb8582874d3
a2e211f7bd379c81e9c393637803a0a0
f64fa85e00cad9a1523513becac836e0
63741801137148abfa4c00cd547dcdfa
373fd575114a743d502a979c6161b1ad
author_id_fullname_str_mv 5399f4c6e6a70f3608a084ddb938511a_***_Steve Bain
8092562c67809dfda89f7bb8582874d3_***_Gary Christopher
a2e211f7bd379c81e9c393637803a0a0_***_Christopher George
f64fa85e00cad9a1523513becac836e0_***_Hasan Haboubi
63741801137148abfa4c00cd547dcdfa_***_Venkat Kanamarlapudi
373fd575114a743d502a979c6161b1ad_***_Jeremy Tree
author Steve Bain
Gary Christopher
Christopher George
Hasan Haboubi
Venkat Kanamarlapudi
Jeremy Tree
author2 Emma Short
(ICCARP)
Stuart Calimport
Barry Bentley
Ian M. Adcock
Bilal Al-Sarireh
Ann Ager
Ramzi Ajjan
Naveed Akbar
Michael A. Akeroyd
Ghada Alsaleh
Ghada Al-Sharbatee
Kambiz Alavian
Winfried Amoaku
Julie Andersen
Chrystalina Antoniades
Mark J. Arends
Sue Astley
Denize Atan
Richard Attanoos
Johannes Attems
Steve Bain
Konstantinos Balaskas
Gabriel Balmus
Manohar Bance
Thomas M. Barber
Ajoy Bardhan
Karen Barker
Peter Barnes
Gemma Basatemur
Adrian Bateman
Moises Evandro Bauer
Christopher Bellamy
Edwin van Beek
Ilaria Bellantuono
Emyr Benbow
Sunil Bhandari
Rahul Bhatnagar
Philip Bloom
Dawn Bowdish
Melissa Bowerman
Melanie Burke
Roxana Carare
Emma Victoria Carrington
Jorge Iván Castillo-Quan
Peter Clegg
James Cole
Carlo Cota
Paul Chazot
Christopher Chen
Ying Cheong
Gary Christopher
George Church
David Clancy
Paul Cool
Del Galdo
Mayank Dalakoti
Soumit Dasgupta
Colleen Deane
Devesh Dhasmana
Stefan Dojcinov
Monia Di Prete
Huaidong Du
Niharika A. Duggal
Toby Ellmers
Costanza Emanueli
Mark Emberton
Jorge D. Erusalimsky
Laurence Feldmeyer
Alexander Fleming
Karen Forbes
Thomas C. Foster
Daniela Frasca
Ian Frayling
Daniel Freedman
Tamas Fülöp
Georgina Ellison-Hughes
Gus Gazzard
Christopher George
Jesus Gil
Richard Glassock
Rob Goldin
John Green
Robyn Guymer
Hasan Haboubi
Lorna Harries
Simon Hart
Douglas Hartley
Sebri Hasaballa
Christin Henein
Maggie Helliwell
Emily Henderson
Rakesh Heer
Kristofer Holte
Iskander Idris
David Isenburg
Juulia Jylhävä
Ahmed Iqbal
Simon W. Jones
Rajesh Kalaria
Venkat Kanamarlapudi
Werner Kempf
Alexandra J. Kermack
Jemma Kerns
Albert Koulman
Adnan H. Khan
James Kinross
Katarina Klaucane
Yamini Krishna
Harinderjit Singh Gill
Edward Lakatta
Ezio Laconi
Alpar Lazar
Christiaan Leeuwenburgh
Samantha Leung
Xuan Li
Ian van der Linde
Luísa V. Lopes
Antonello Lorenzini
Andrew Lotery
Pedro Machado
Sarah Mackie
Paolo Madeddu
Andrea Maier
Krishna Mukkanna
Pinelopi Manousou
Oonagh Markey
Claudio Mauro
Barry McDonnell
Reinhold J. Medina
Soma Meran
Claudia Metzler-Baddeley
Ignor Meglinksi
Neta Milman
Christina Mitteldorf
Ruth Montgomery
Andrew Conway Morris
Beda Mühleisen
Abhik Mukherkee
Andrew Murray
Scott Nelson
Anna Nicolaou
Alexander Nirenberg
Simon Noble
Lisa S. Nolan
Meritxell Nus
Canh Van On
Victor Osei-Lah
Mandy Peffers
Antony Palmer
Donald Palmer
Laura Palmer
William Parry-Smith
Graham Pawelec
Shahaf Peleg
Ranmith Perera
Andrew Pitsillides
Christopher J. Plack
Franze Progatzsky
Sonja Pyott
Kaukab Rajput
Sameera Rashid
J. Arjuna Ratnayaka
Sudhira A. B. Ratnayake
Manuel Rodriguez-Justo
Arianna Carolina Rosa
Andrew Rule
Gareth J. Sanger
Ian Sayers
Andrew Saykin
Dinesh Selvarajah
Jaswinder Sethi
Cathy Shanahan
Shai Shen-Orr
Carl Sheridan
Paul Shiels
Kastytis Sidlauskas
Sobha Sivaprasad
Judith Sluimer
Gary Small
Peter Smith
Rebecca Smith
Sarah Snelling
Ioakim Spyridopoulos
Ramasamy Srinivasa Raghavan
David Steel
Karen P. Steel
Claire Stewart
Keeron Stone
Selvarani Subbarayan
Mark Sussman
Jonas Svensson
Vyshnavi Tadanki
Ai Lyn Tan
Rudolph E. Tanzi
Amanda Tatler
Adriana A. S. Tavares
Tengku Amatullah Madeehah Tengku Mohd
Ana Tiganescu
James Timmons
Jeremy Tree
Drupad Trivedi
Emmanuel A. Tsochatzis
Dialechti Tsimpida
Elisabeth J. Vinke
Anna Whittaker
Neeru A. Vallabh
Kristin Veighey
Zoe C. Venables
Reddy Venkat
Meike W. Vernooij
Chris Verschoor
Manlio Vinciguerra
Vesna Vukanovic
Vladyslav Vyazovskiy
James Walker
Richard Wakefield
Adam J. Watkins
Anthony Webster
Caroline Weight
Birgit Weinberger
Susan L. Whitney
Rosalind Willis
Jacek M. Witkowski
Leonard L. L. Yeo
Tham Yhi Chung
Emma Yu
Michael Zemel
format Journal article
container_title GeroScience
container_volume 47
container_issue 2
container_start_page 1713
publishDate 2025
institution Swansea University
issn 2509-2723
doi_str_mv 10.1007/s11357-024-01315-9
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
active_str 0
description Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndromes. This will allow societies to better identify, quantify, understand and meet the healthcare, workforce, well-being and socioeconomic needs of ageing populations, whilst supporting the development and utilisation of interventions to prevent or to slow, halt or reverse the progression of ageing-related pathologies. The foundation for developing such classification and staging systems is to define the scope of what constitutes an ageing-related pathology, disease or syndrome. To this end, a consensus meeting was hosted by the International Consortium to Classify Ageing-Related Pathologies (ICCARP), on February 19, 2024, in Cardiff, UK, and was attended by 150 recognised experts. Discussions and voting were centred on provisional criteria that had been distributed prior to the meeting. The participants debated and voted on these. Each criterion required a consensus agreement of ≥ 70% for approval. The accepted criteria for an ageing-related pathology, disease or syndrome were (1) develops and/or progresses with increasing chronological age; (2) should be associated with, or contribute to, functional decline or an increased susceptibility to functional decline and (3) evidenced by studies in humans. Criteria for an ageing-related pathology, disease or syndrome have been agreed by an international consortium of subject experts. These criteria will now be used by the ICCARP for the classification and ultimately staging of ageing-related pathologies, diseases and syndromes.
published_date 2025-04-01T05:22:19Z
_version_ 1851369287504101376
score 11.089572

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