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A mechanistic framework for complex microbe-host symbioses

Gui Araujo, José M. Montoya, Torsten Thomas, Nicole S. Webster, Miguel Lurgi Rivera Orcid Logo

Trends in Microbiology, Volume: 33, Issue: 1, Pages: 96 - 111

Swansea University Author: Miguel Lurgi Rivera Orcid Logo

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DOI (Published version): 10.1016/j.tim.2024.08.002

Abstract

Virtually all multicellular organisms on Earth live in symbiotic associations with complex microbial communities: the microbiome. This ancient relationship is of fundamental importance for both the host and the microbiome. Recently, the analyses of numerous microbiomes have revealed an incredible di...

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Published in: Trends in Microbiology
ISSN: 0966-842X 1878-4380
Published: Elsevier BV 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa67601
first_indexed 2024-09-06T09:34:58Z
last_indexed 2025-01-31T14:29:27Z
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spelling 2025-01-31T11:21:17.8343248 v2 67601 2024-09-06 A mechanistic framework for complex microbe-host symbioses 947df89d116a1ab75515e421089e0443 0000-0001-9891-895X Miguel Lurgi Rivera Miguel Lurgi Rivera true false 2024-09-06 BGPS Virtually all multicellular organisms on Earth live in symbiotic associations with complex microbial communities: the microbiome. This ancient relationship is of fundamental importance for both the host and the microbiome. Recently, the analyses of numerous microbiomes have revealed an incredible diversity and complexity of symbionts, with different mechanisms identified as potential drivers of this diversity. However, the interplay of ecological and evolutionary forces generating these complex associations is still poorly understood. Here we explore and summarise the suite of ecological and evolutionary mechanisms identified as relevant to different aspects of microbiome complexity and diversity. We argue that microbiome assembly is a dynamic product of ecology and evolution at various spatio-temporal scales. We propose a theoretical framework to classify mechanisms and build mechanistic host-microbiome models to link them to empirical patterns. We develop a cohesive foundation for the theoretical understanding of the combined effects of ecology and evolution on the assembly of complex symbioses. Journal Article Trends in Microbiology 33 1 96 111 Elsevier BV 0966-842X 1878-4380 eco-evolution; metacommunity; population dynamics; complex networks; model selection; symbiosis 1 1 2025 2025-01-01 10.1016/j.tim.2024.08.002 Review COLLEGE NANME Biosciences Geography and Physics School COLLEGE CODE BGPS Swansea University SU Library paid the OA fee (TA Institutional Deal) G.A. and M.L. are supported by the Leverhulme Trust through Research Project Grant # RPG-2022-114. J.M.M. is partially supported by the French ANR through LabEx TULIP (ANR-10-LABX-41). 2025-01-31T11:21:17.8343248 2024-09-06T10:25:07.9838498 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Gui Araujo 1 José M. Montoya 2 Torsten Thomas 3 Nicole S. Webster 4 Miguel Lurgi Rivera 0000-0001-9891-895X 5 67601__33456__defec1898f334910a39231fb118e3a5a.pdf 67601.VOR.pdf 2025-01-31T11:18:50.8003080 Output 1438696 application/pdf Version of Record true © 2024 The Author(s). This is an open access article distributed under the terms of the Creative Commons CC-BY license. true eng http://creativecommons.org/licenses/by/4.0/
title A mechanistic framework for complex microbe-host symbioses
spellingShingle A mechanistic framework for complex microbe-host symbioses
Miguel Lurgi Rivera
title_short A mechanistic framework for complex microbe-host symbioses
title_full A mechanistic framework for complex microbe-host symbioses
title_fullStr A mechanistic framework for complex microbe-host symbioses
title_full_unstemmed A mechanistic framework for complex microbe-host symbioses
title_sort A mechanistic framework for complex microbe-host symbioses
author_id_str_mv 947df89d116a1ab75515e421089e0443
author_id_fullname_str_mv 947df89d116a1ab75515e421089e0443_***_Miguel Lurgi Rivera
author Miguel Lurgi Rivera
author2 Gui Araujo
José M. Montoya
Torsten Thomas
Nicole S. Webster
Miguel Lurgi Rivera
format Journal article
container_title Trends in Microbiology
container_volume 33
container_issue 1
container_start_page 96
publishDate 2025
institution Swansea University
issn 0966-842X
1878-4380
doi_str_mv 10.1016/j.tim.2024.08.002
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
active_str 0
description Virtually all multicellular organisms on Earth live in symbiotic associations with complex microbial communities: the microbiome. This ancient relationship is of fundamental importance for both the host and the microbiome. Recently, the analyses of numerous microbiomes have revealed an incredible diversity and complexity of symbionts, with different mechanisms identified as potential drivers of this diversity. However, the interplay of ecological and evolutionary forces generating these complex associations is still poorly understood. Here we explore and summarise the suite of ecological and evolutionary mechanisms identified as relevant to different aspects of microbiome complexity and diversity. We argue that microbiome assembly is a dynamic product of ecology and evolution at various spatio-temporal scales. We propose a theoretical framework to classify mechanisms and build mechanistic host-microbiome models to link them to empirical patterns. We develop a cohesive foundation for the theoretical understanding of the combined effects of ecology and evolution on the assembly of complex symbioses.
published_date 2025-01-01T08:12:54Z
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